A Comparative Research between Pharmacological and Non-Pharmacological Profile of Anti-Hyperlipidemic Activity on Rodents

Authors

Abstract

The condition of hyperlipidemia is found to be a great establisher for all the negative health consequences which may lead to cardiac complications. Continuous usage of medication alone is not permanent remedy but also need physical exercise. The same situation was established in animals to assess the performance of pharmacological and non-pharmacological profile by standardized screening using In-vivo methods. The high-cholesterol diet caused a significant increase in total lipids, total cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and the atherogenic index, whereas the level of high-density lipoprotein cholesterol (HDL-C) was significantly decreased for the treatment groups intended for physical exercise. This article enables the importance of health benefited by physical performance by depicting the biochemical parameters.

Keywords: Hyperlipidemia, Triglycerides, low-density lipoprotein, activity wheel, Physical exercise, Cardiac performance.

Keywords:

Hyperlipidemia, Triglycerides, low-density lipoprotein, activity wheel, Physical exercise, Cardiac performance

DOI

https://doi.org/10.22270/jddt.v11i5.5016

Author Biographies

Darsi Eswar Tony, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur, 522034, India

Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur, 522034, India

M. Uday Kiran, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

Md. Abu Saleha, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

R. Suresh Naik, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

U. Bhargav Sai, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

V. Niranjan, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

T. Kowshik, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

Rama Rao Nadendla, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

References

Gloria A. Otunola1, Oyelola B. Oloyede, Adenike T. Oladiji and Anthony A. Afolayan, Effects of diet-induced hypercholesterolemia on the lipid profile and some enzyme activities in female Wistar rats, African Journal of Biochemistry Research, 2010; 4(6):149-154.

Arun Babu Vuyyuru, Sarita Kotagiri, Vrushabendra Swamy BM , Archana Swamy P. Antihyperlipidemic Activity of Ananas Comosus L. Leaves Extract in Albino Rats. RJPBCS, 2012; 3(3):1229-1242.

Hayashi T, Hirano T, Yamamoto T, Ito Y, Adachi M. Intensive insulin therapy reduces small dense low-density lipoprotein particles in patients' with type 2 diabetes mellitus, relationship to triglyceride-rich lipoprotein subspecies. Metabolism, 2006; 55(7):879-84. https://doi.org/10.1016/j.metabol.2006.02.014

Mendis S, Puska P, Norrving B. Global atlas on cardiovascular disease prevention and control. World Health Organization, 2011.

Singha B, Borah A, Swopna P. Hypolipidemic activity of Phyllanthus acidus leaves in Hypercholesterolemic diet-induced hyperlipidemia in rats, Sch. J. App. Med. Sci, 2016; 4(10B):3648-3653.

Gloria A. Otunola1, Oyelola B. Oloyede, Adenike T. Oladiji and Anthony A. Afolayan. Effects of diet-induced hypercholesterolemia on the lipid profile and some enzyme activities in female Wistar rats. African Journal of Biochemistry Research, 2010; 4(6):149-154.

Bailey J, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care, 1989; 12:553-64. https://doi.org/10.2337/diacare.12.8.553

Blois MS. Antioxidant determinations by the use of a stable free radical. Nature, 1958; 181:1199-1200. https://doi.org/10.1038/1811199a0

Burstein M, Scholnick HR, Morgin R. Rapid method for the isolation of lipoprotein from human serum by precipitation with polyanion. Journal of Lipid Research, 1970; 11:1583-86. https://doi.org/10.1016/S0022-2275(20)42943-8

Abedulla Khan K. A preclinical antihyperlipidemic evaluation of Artemisia vulgaris root in diet induced hyperlipidemic animal model. IJPR, 2015; 5(4):110-114.

Pandya N, Santani D, Jain S. Antioxidant activity of ezetimibe in hypercholesterolemic rats. Ind. J. Pharmacol, 2006; 38:205-206. https://doi.org/10.4103/0253-7613.25811

Arun Babu Vuyyuru, Sarita Kotagiri, Vrushabendra Swamy BM, Archana Swamy P. Antihyperlipidemic Activity of Ananas Comosus L. Leaves Extract in Albino Rats. RJPBCS, 2012; 3(3):1229-1242.

Singha B, Borah A, Swopna P. Hypolipidemic activity of Phyllanthus acidus leaves in Hypercholesterolemic diet-induced hyperlipidemia in rats, Sch. J. App. Med. Sci, 2016; 4(10B):3648-3653.

Colleen M. Novak et al; The use of a running wheel to measure activity in rodents: Relationship to energy balance, general activity, and reward. Neuroscience and Biobehavioral Reviews 2012; 36:1001-1014. https://doi.org/10.1016/j.neubiorev.2011.12.012

Published

2021-09-15
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How to Cite

1.
Tony DE, Kiran MU, Saleha MA, Naik RS, Sai UB, Niranjan V, et al. A Comparative Research between Pharmacological and Non-Pharmacological Profile of Anti-Hyperlipidemic Activity on Rodents. J. Drug Delivery Ther. [Internet]. 2021 Sep. 15 [cited 2026 Jan. 25];11(5):65-70. Available from: https://jddtonline.info/index.php/jddt/article/view/5016

How to Cite

1.
Tony DE, Kiran MU, Saleha MA, Naik RS, Sai UB, Niranjan V, et al. A Comparative Research between Pharmacological and Non-Pharmacological Profile of Anti-Hyperlipidemic Activity on Rodents. J. Drug Delivery Ther. [Internet]. 2021 Sep. 15 [cited 2026 Jan. 25];11(5):65-70. Available from: https://jddtonline.info/index.php/jddt/article/view/5016

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