Formulation and preclinical evaluation of Anti-inflammatory activity of Triticum aestivum

  • Sai Krishna Priya Dasari Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Andhra Pradesh, Guntur-522034, India
  • Pallavi Vadlamudi Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Andhra Pradesh, Guntur-522034, India
  • Rama Rao Nadendla Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Andhra Pradesh, Guntur-522034, India

Abstract

A wide scope of medical advantages has been credited to wheatgrass, the young grass of the wheat plant Tritium aestivum. Wheat grass is a decent wellspring of mineral supplements. It contains critical measures of iron, phosphorous, magnesium, manganese, copper and zinc. Wheatgrass is a rich supplement of tocopherols with high vitamin E content. Wheatgrass is beneficial in restoring more infections due to its significant function that, it can arrest the development of antagonistic microbes which are responsible for spreading certain diseases. constituents of wheatgrass may be obtained from fresh juice, frozen juice, powder, tablets with compositions differing as per their production methods which otherwise depends on growing conditions of wheatgrass. Anti-inflammatory activity of wheatgrass tablets was assessed by using formalin induced rat paw edema model. The results obtained were compared with aceclofenac, standard drug.


Keywords: Triticum aestivum, Flaxseed gel, Anti-inflammatory, Aceclofenac, Formalin.

Keywords: Triticum aestivum, Flaxseed gel, Anti-inflammatory, Aceclofenac, Formalin

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Author Biographies

Sai Krishna Priya Dasari, Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Andhra Pradesh, Guntur-522034, India

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Andhra Pradesh, Guntur-522034, India

Pallavi Vadlamudi, Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Andhra Pradesh, Guntur-522034, India

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Andhra Pradesh, Guntur-522034, India

Rama Rao Nadendla, Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Andhra Pradesh, Guntur-522034, India

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Andhra Pradesh, Guntur-522034, India

References

1. Sundaresan A, Selvi A, Manonmani HK. The Anti-Microbial Properties of Triticum aestivum ( Wheat Grass ) Extract. Int J Biotechnol Wellness Ind. 2015; 2015(4):84–91.
2. Rana S, Kamboj JK, Gandhi V. Living life the natural way - Wheatgrass and health. Funct Foods Heal Dis. 2011; 1(11):444–56.
3. Arya P, Kumar M. Chemoprevention by Triticum aestivum of mouse skin carcinogenesis induced by DMBA and croton oil - Association with oxidative status. Asian Pacific J Cancer Prev [Internet]. 2011 [cited 2021 Apr 30]; 12(1):143–8. Available from: https://pubmed.ncbi.nlm.nih.gov/21517247/
4. Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P. Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes. Carcinogenesis. 2005; 26(7):1247–55.
5. Wheat J, Currie G. Herbal medicine for cancer patients: An evidence based review. Internet J Altern Med. 2012; 5(2):1–11.
6. Nenonen MT, Helve TA, Rauma A-L, Ha¨nninen OO, Ha¨nninen H. UNCOOKED, LACTOBACILLI-RICH, VEGAN FOOD AND RHEUMATOID ARTHRITIS. Vol. 37, British Journal of Rheumatology. 1998.
7. Demidov L V., Manziuk L V., Kharkevitch GY, Pirogova NA, Artamonova E V. Adjuvant fermented wheat germ extract (AvemarTM) nutraceutical improves survival of high-risk skin melanoma patients: A randomized, pilot, phase II clinical study with a 7-year follow-up. Cancer Biother Radiopharm. 2008; 23(4):477–82.
8. Patel D, Patel U, Shukla M, Bhimani B, Patel G. Formulation and Evaluation of Immediate Release Tablet of Simvastatin. Res J Pharm Technol. 2020; 13(1):421.
9. Kulkarni RS, Behera AL. Formulation and Evaluation of Immediate Release Tablet of Valsartan. Int J Pharm Sci Res [Internet]. 2015; 6(2):808. Available from: http://dx.doi.org/10.13040/IJPSR.0975-8232.6
10. Nyol S, Gupta MM. Immediate Drug Release Dosage Form: a Review. J Drug Deliv Ther. 2013; 3(2):155–61.
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Dasari SKP, Vadlamudi P, Nadendla RR. Formulation and preclinical evaluation of Anti-inflammatory activity of Triticum aestivum. JDDT [Internet]. 15May2021 [cited 18Sep.2021];11(3):65-9. Available from: https://jddtonline.info/index.php/jddt/article/view/4781