Phytochemical Profile and Antioxidant Potential of Berberis aristata Bark in Diabetes Mellitus Management

Authors

Abstract

Diabetes mellitus is a long known metabolic disorder that is afflicting millions of people all over the world. High levels of blood sugar (also known as glucose) in the blood that can develop into other health problems if untreated, this is the main feature. In this case the body cannot make enough insulin to regulate blood sugar or does not use insulin properly. Diabetes have two types, i.e. diabetes 1st type and diabetes 2nd type. Chronic diseases both are called diabetes that affect how glucose is processed in the body causing blood sugar levels to be high. They however have different causes, symptoms, and treatment options.A plant of the Berberidaceae family, Berberis aristata is often called Indian Barberry or Tree Turmeric. The traditional use of Berberis aristata has been very long. One of its many active ingredients, berberine has shown antimicrobial, anti inflammatory as well as antioxidant and antidiabetic properties. The plant is used for treating numerous medical conditions, e.g. digestive problems, respiratory infections, skin conditions, diabetes. The Berberis aristata in ayurvedic medicine is used in diabetes and diabetes related complications. It is understood to improve insulin sensitivity and to promote glucose uptake by the cells to help with blood sugar levels. Berberis aristata is a long traditional medicine. Antimicrobial, antidiabetic, antioxidant and anti-inflammatory properties have been demonstrated for one of its many active ingredients, berberine, although it is not believed to be the most important one when it comes to diabetes. The plant is used for treatment of numerous medical conditions such as digestive, respiratory infection, skin, and diabetes.

Keywords: Diabetes mellitus, Antioxidant, Berberine, Berberis aristata

Keywords:

Diabetes mellitus, Antioxidant, Berberine, Berberis aristata

DOI

https://doi.org/10.22270/jddt.v15i4.7086

Author Biographies

Vivek Dwivedi , Chandra Shekhar Singh College of Pharmacy, Koilaha, Kaushambi, 212213, India

Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, 211007, India

 

Shahnawaz Sameem , Medicinal Chemistry Research Laboratory, Faculty of Pharmacy, United University, Prayagraj, 211012, India

Medicinal Chemistry Research Laboratory, Faculty of Pharmacy, United University, Prayagraj, 211012, India

Amita Verma , Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, 211007, India

Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, 211007, India

References

1. Prakash, S., & Gupta S, Phytochemical and pharmacological properties of Berberis aristata: A review. Indian Journal of Natural Products and Resources 2010;83(5):817-830 https://doi.org/10.1016/j.fitote.2012.04.012 PMid:22808523

2. Bhardwaj A., Medicinal potential of Berberis aristata: An overview. International Journal of Pharmaceutical Sciences and Research 2017;8(2):98-102

3. Gupta A., Therapeutic potential of Berberis aristata: A review on its pharmacology and clinical applications. Journal of Herbal Medicine 2016; 6(1): 18-26

4. Dwivedi C., & Daspaul S., Antidiabetic herbal drugs and polyherbal formulation used for diabetes: A review. 2013;2(3):44-51 https://doi.org/10.31254/phyto.2013.21308

5. Zhao, Y., Berberine: A review of its pharmacology, pharmacokinetics, and therapeutic potential. Phytotherapy Research 2017; 31(3): 411-420.

6. Zhang, X., Berberine improves insulin sensitivity and reduces inflammatory responses in metabolic disorders. Journal of Clinical Endocrinology & Metabolism, 2019; 104(3): 1153-1162.

7. Alam, M. S., Antioxidant and antimicrobial activity of Berberis aristata extract. International Journal of Pharmaceutical Sciences and Research, 2018; 9(4):1202-1208.

8. Chatterjee, A., Hepatoprotective effect of Berberis aristata on drug-induced liver toxicity. Indian Journal of Pharmaceutical Sciences, 2014; 76(2): 138-143.

9. Bisht, D., A comprehensive review on medicinal properties of Berberis aristata. International Journal of Research in Pharmaceutical Sciences, 2017; 8(3):14-19.

10. Pattnaik, S., Evaluation of the antidiabetic potential of Berberis aristata root extract in streptozotocin-induced diabetic rats. Pharmacognosy Research, 2012; 4(4): 220-225.

11. Chauhan, N.,Conservation and sustainable harvesting of Berberis aristata in the Himalayan region. Environmental Management, 2015;56(4): 893-900.

12. Ibrahim, H.A.A. and Vora, P. J., Diabetic nephropathy. Bailliere's Clinical Endocrinology Metabolism, 1999 ;13: 239-264. https://doi.org/10.1053/beem.1999.0018 PMid:10761865

13. Joshi, V. K., Joshi, A., & Dhiman, K. S., The Ayurvedic Pharmacopoeia of India, development and perspectives. Journal of Ethnopharmacology, 2017; 197: 32-38. https://doi.org/10.1016/j.jep.2016.07.030 PMid:27404231

14. Kadian R, Parle M, Yadav M. Therapeutic potential and phytopharmacology of Terminalia bellerica. World Journal of Pharmacy and Pharmaceutical Sciences. 2014; 3(10):804-819.

15. Kagami, S., Border, W. A., Miller, D. E. and Noble, N.A., Angiotensin II stimulated extracellular matrix protein synthesis through induction of transforming growth-factor β expression in rat glomerular cells. Journal Clinical Investigation, 1994; 93: 2431-2437. https://doi.org/10.1172/JCI117251 PMid:8200978 PMCid:PMC294451

16. Ghosh, P., Toxicity evaluation of Berberis aristata extracts: An in vivo study. Toxicology Reports, 2018;5: 64-69.

17. Kokate C.K., Handbook of Practical Pharmacognosy, Vallabh Prakashan. 1994; 4: 44-58

18. Kokate, C. K., Purohit, A.P., & Gokhale, S. B. Pharmacognosy. Vallabh Prakashan 2014;5:50-59

19. Marshall SM, Recent advances in diabetic nephropathy. Clinical medicine. 2004;4(3): 277-282. https://doi.org/10.7861/clinmedicine.4-3-277 PMid:15244365 PMCid:PMC4953593

20. Mukopadhay P, Pan H, Rajesh M, Bathai S, Patel v, Harvey-White J, et al, CB1 cannabinoid receptors promote oxidative stress, inflammation and cell death in a murine nephropathy model.Br J Pharmacology. 2010; 160:657-684. https://doi.org/10.1111/j.1476-5381.2010.00769.x PMid:20590569 PMCid:PMC2931565

21. Perkins BA, Bril V. Diabetic neuropathy: A review emphasizing diagnostic methods. Clinical Neurophysiology. 2003; 114(7):1167-1175. https://doi.org/10.1016/S1388-2457(03)00025-7 PMid:12842711

22. Prabhakar, S., Starnes, J., Shi, S., Lonis, B. and Tran, R., Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide production. Journal American Society Nephrology, 2007; 18: 2945-2952. https://doi.org/10.1681/ASN.2006080895 PMid:17928507

23. Satyanarayana, K., Sravanthi, K., Shaker, I. A., & Ponnulakshmi, R. (2015). Molecular approach toidentify antidiabetic potential of Azadirachta indica. Journal of Ayurveda and Integrative Medicine, 2015; 6(3):165-174. https://doi.org/10.4103/0975-9476.157950 PMid:26604551 PMCid:PMC4630690

24. Sharma, K., and Ziyadeh F. N. Hyperglycaemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator. Diabetes, 1995; 44:1139-1146. https://doi.org/10.2337/diab.44.10.1139 PMid:7556948

25. Sugimoto K, Yasujima M, Yagihashi. Role of advanced glycation end products in diabetic neuropathy. Curr Pharm. 2008; 14(10):953-961 https://doi.org/10.2174/138161208784139774 PMid:18473845

26. Thillaivanan, S., & Samraj, K., Challenges, constraints and opportunities in herbal medicines-areview. International Journal of Herbal Medicine, 2014;2(1): 21

27. Khandelwal, K., Practical Pharmacognosy: Techniques and Experiments Nirali Prakashan,2017;28:54-70

Published

15-04-2025
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How to Cite

1.
Dwivedi V, Sameem S, Verma A. Phytochemical Profile and Antioxidant Potential of Berberis aristata Bark in Diabetes Mellitus Management. J. Drug Delivery Ther. [Internet]. 2025 Apr. 15 [cited 2025 Apr. 26];15(4):108-12. Available from: https://jddtonline.info/index.php/jddt/article/view/7086

How to Cite

1.
Dwivedi V, Sameem S, Verma A. Phytochemical Profile and Antioxidant Potential of Berberis aristata Bark in Diabetes Mellitus Management. J. Drug Delivery Ther. [Internet]. 2025 Apr. 15 [cited 2025 Apr. 26];15(4):108-12. Available from: https://jddtonline.info/index.php/jddt/article/view/7086