Enhancing Herbal Efficacy: Synthesis and Evaluation of Nanosuspension from Withania somnifera Root Extract

Authors

Abstract

Background: Ayurveda emphasizes the balance of mind, body, and spirit, drawing on ancient texts that highlight the medicinal properties of herbs like Withania somnifera, known for its wide range of therapeutic applications and pharmacological benefits. Commonly referred to as Indian ginseng or Ashwagandha, Withania somnifera, demonstrates a variety of therapeutic effect , including anti-inflammatory, antitumor, sedative, hypnotic, deobstruent effects, narcotic, antioxidant, tonic, antistress, diuretic, aphrodisiac, immunomodulatory, and rejuvenating properties. Nanotechnology, particularly through the development of nanosuspensions, offers a significant advancement in medicine, addressing challenges like poor solubility and low bioavailability of lipophilic drugs. Nanosuspensions can enhance drug safety and efficacy by improving solubility and altering pharmacokinetics.

Methods: This study focuses on formulating and characterizing a nanosuspension using an ethanolic extract of Withania somnifera roots. The nanosuspension (NSWS) underwent comprehensive characterization, utilizing techniques such as FT-IR spectroscopy, particle size analysis, zeta potential measurement, polydispersity index (PDI) assessment, Field emission scanning electron microscopy (FESEM), X-ray diffraction analysis, pH measurement, and stability testing. This study seeks to explore the potential of nanosuspensions, aiming to integrate nanotechnology with herbal medicine to improve the safety and efficacy of herbal formulations.

Results: The nanosuspension (NSWS) shown particle size about 133.09 nm, and its uniform particle distribution was indicated by a Polydispersity Index (PDI) about 0.27. Stability and uniformity were further supported by the zeta potential, particle size, and PDI values.

Conclusion: Nanosuspension formulations represents a versatile strategy to improve the therapeutic efficacy of hydrophobic drugs across various routes of administration.

Keywords: Withania somnifera, Nanosuspension, Characterization, FT-IR, PDI, FESEM

Keywords:

Withania somnifera, Nanosuspension, Characterization, FT-IR, PDI, FESEM

DOI

https://doi.org/10.22270/jddt.v14i10.6848

Author Biographies

Chandrashekhar Chauriya, RBUSS’s Ravi Institute of Diploma in Pharmacy, Nagpur, Maharashtra, 441111, India

Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Prayagraj, 211007, India

Mahesh Sahu, Sonekar College of Pharmacy, Nagpur, Maharashtra, 441111, India

Sonekar College of Pharmacy, Nagpur, Maharashtra, 441111, India

Vikas Kumar, University Centre for Research and Development, Chandigarh University, Gharuan, Punjab, 140413, India

Natural Product Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Prayagraj, 211007, India

Amita Verma, Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Prayagraj, 211007, India

Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Prayagraj, 211007, India

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Published

15-10-2024
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How to Cite

1.
Chauriya C, Sahu M, Kumar V, Verma A. Enhancing Herbal Efficacy: Synthesis and Evaluation of Nanosuspension from Withania somnifera Root Extract. J. Drug Delivery Ther. [Internet]. 2024 Oct. 15 [cited 2025 Jan. 17];14(10):70-7. Available from: https://jddtonline.info/index.php/jddt/article/view/6848

How to Cite

1.
Chauriya C, Sahu M, Kumar V, Verma A. Enhancing Herbal Efficacy: Synthesis and Evaluation of Nanosuspension from Withania somnifera Root Extract. J. Drug Delivery Ther. [Internet]. 2024 Oct. 15 [cited 2025 Jan. 17];14(10):70-7. Available from: https://jddtonline.info/index.php/jddt/article/view/6848