Assessment of Renal Insufficiency among Patients under Anti-retroviral Therapy at Gitwe District Hospital
Abstract
Background: Several antiretroviral agents (ARVs) are associated with chronic renal impairment. Renal insufficiency is poor function of the kidneys that may be due to a reduction in blood-flow to the kidneys caused by renal artery disease. Globally the prevalence of renal insufficiency, defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2, among Adolescents living with HIV (ALHIV) ranges between 3% - 7%.
Aim: This study aims to determine the Prevalence of Renal Insufficiency among Patients under Antiretroviral Therapy at Gitwe District Hospital.
Methodology: An institution-based retrospective study was conducted from 2023 to 2024 on a subset of HIV-infected patients. Data were collected from the register book of patients under antiretroviral therapy attending Gitwe District Hospital.
Results: After data analysis, the findings have shown that the majority of patients 68(46.9%) were with moderate renal insufficiency, 53(36.6%) were with mild renal insufficiency, 20(13.8%) were with normal kidney function and 4(2.8%) were with severe renal insufficiency.
Conclusion: Moderate and mild renal insufficiency have a high prevalence among patients exposed to antiretroviral therapy at Gitwe District Hospital. Severe renal insufficiency was observed to be reduced in HIV Patients exposed to ART. Normal kidney cases were few compared to renal insufficiency cases. Further studies are recommended to determine the need of drinking water in prevention of progression from mild and moderate to severe renal insufficiency.
Keywords: Renal insufficiency, Antiretroviral Therapy, HIV.
Keywords:
Renal insufficiency, Antiretroviral Therapy, HIVDOI
https://doi.org/10.22270/jddt.v15i8.7036References
1. Ssemasaazi, A. J. Higher prevalence of kidney function impairment among older people living with HIV in Uganda. , . BMC nephrology, 2024; 25(1), 321. https://doi.org/10.1186/s12882-024-03761-1 PMid:39334034 PMCid:PMC11428404
2. Ryom, L. M. Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D: A: D Studya. . The Journal of infectious diseases,2013; 1359-1369. https://doi.org/10.1093/infdis/jit043 PMid:23382571 PMCid:PMC3610424
3. Ottaru, T. A. Prevalence and Risk Factors for Renal Insufficiency among Adults Living with HIV in Tanzania: Results from a Cross-Sectional Study in 2020-2021. In Healthcare , 2024;657. https://doi.org/10.3390/healthcare12060657 PMid:38540623 PMCid:PMC10970453
4. Achhra, A. C.Chronic kidney disease and antiretroviral therapy in HIV-positive individuals: recent developments. . Current HIV/AIDS Reports,2016; 149-157. https://doi.org/10.1007/s11904-016-0315-y PMid:27130284
5. WHO. (2013). HIV and adolescents: guidance for HIV testing and counselling and care for adolescents living with HIV: recommendations for a public health approach and considerations for policy-makers and managers. Retrieved from WHO: https://www.ncbi.nlm.nih.gov/books/NBK217963/
6. Nzitakera, A. M. Kidney Impairment in HIV/AIDS Patients Attending Kabutare Level II Teaching Hospital, Southern Province of Rwanda. . Rwanda Journal of Medicine and Health Sciences,2024; 151-164. https://doi.org/10.4314/rjmhs.v7i2.5 PMid:40567849 PMCid:PMC12110560
7. Alain Prudence I, Donatien M, Tharcisse G, Israel H, Marie Louise M, Lauben N, Effects of Anti-Retroviral Drugs on Liver and Kidney function among HIV Patients Attending Gitwe District Hospital, Journal of Drug Delivery and Therapeutics. 2025; 15(2):29-33 DOI: http://dx.doi.org/10.22270/jddt.v15i2.6863
8. Tamuno, I. E.-C. Renal dysfunction in HIV-infected patients commencing antiretroviral therapy in a treatment centre in southern Nigeria. . Babcock University Medical Journal,2024;96-106. https://doi.org/10.38029/babcockuniv.med.j..v7i1.327
9. Asmelash, D.Chronic kidney disease and its associated factors in HIV-infected individuals: a comparison of antiretroviral therapy naïve and experienced patients. . Frontiers in Medicine, 2024;1455688. https://doi.org/10.3389/fmed.2024.1455688 PMid:39588184 PMCid:PMC11586211
10. Anastasie, W. M. Prevalence of Chronic Kidney Disease and Associated Factors among HIV Patients in the Era of HAART in Ivory Coast: A Cross Sectional, Analytical Study. Open Journal of Nephrology,2023; 13(1), 20-30. https://doi.org/10.4236/ojneph.2023.131004
11. UMUHOZA, Z. (2019). Prevalence of renal dysfunction among HIV patients attending Kabutare District Hospital (Doctoral dissertation, Kibogora Polythechnic).
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Copyright (c) 2025 ISHIMWE Alain Prudence , GATEMBEZI Tharcisse, MUTABAZI Donatien , MUKAMANA Marie Louise , HABIYAREMYE Israel , HAKIZIMANA Philippe , RWANDEMA Joseph , TWAGIRUMUKIZA Gratien , IRAMBONA Kevine
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