Evaluation of CD4 Count in HIV Infected Pregnant Women at Kibagabaga Level Two Teaching Hospital

Authors

  • Evariste NTEZIRIZAZA Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda
  • Ishimwe Alain Prudence Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda
  • Baptiste Jean Habanabakize Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda
  • Tuyishime Jean De Dieu Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda

Abstract

CD4 count measures the degree of immunosuppression in HIV-positive patients and is used to monitor HIV infection progression in human body. HIV is a virus that attacks the body’s immune system and if not treated, can lead to AIDS The rate of CD4 cells destruction is directly proportional to progressive replication of HIV. Pregnant women infected with HIV have high risk of mother to child transmission of HIV infection and are prone to excessive immunosuppression and increased viral load if their CD4 cell count is not properly maintained. Pregnancy may influence CD4 cells count reduction or don’t, that’s why this study focused on evaluation of CD4 count in HIV infected pregnant women. The objectives of this study were to determine the association between pregnancy trimesters and CD4 count among HIV infected pregnant women at KDH. The study was a cross sectional study which included 46 patients who visited kibagabaga level two teaching hospital in 5 months. Data were obtained by collecting venous blood of patients, testing their CD4 count and use of a questionnaire to evaluate the risk factors associated with changes in CD4 count. Data collected were analysed using statistical package for social sciences (SPSS) software version 22.0 and Microsoft word, the presentation of results was done using tables. Variables with p-value less than or equal to 0.05 were considered statistically significant. The study showed that there is an association between pregnancy trimesters and CD4 count among HIV infected pregnant women where 21(45.6%) women were in third trimester and had the highest CD4 count compared to women in the 2nd trimester 14(30.4%) followed by women in 1st trimester 11(24%) with p-value of 0.04 which is statistically significant. In evaluated CD4 count changes, associated risk factors were, antiretroviral treatment intake, diet intake, education level, pregnancy trimester, and closely spaced pregnancies. Which were found to have p-values 0.00, 0.00, 0.04, 0.04 and 0.01 that were statistically significant respectively.

Keywords: HIV, CD4 Count, Pregnant women

Keywords:

HIV, CD4 Count, Pregnant women, HIV, CD4 Count, Pregnant women

DOI

https://doi.org/10.22270/jddt.v14i5.6513

Author Biographies

Evariste NTEZIRIZAZA, Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda

Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda

Ishimwe Alain Prudence, Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda

Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda

Baptiste Jean Habanabakize, Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda

Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda

Tuyishime Jean De Dieu, Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda

Ines-Ruhengeri, Faculty of Applied Fundamental Sciences, Department of Biomedical Laboratory Sciences, Rwanda

References

Ceccarelli, G., Giovanetti, M., Sagnelli, C., Ciccozzi, A., d'Ettorre, G., Angeletti, S., & Ciccozzi, M. Human Immunodeficiency Virus Type 2: The Neglected Threat. Pathogens, 2021; 10(11), 1377. https://doi.org/10.3390/pathogens10111377 PMid:34832533 PMCid:PMC8621479

Gondivkar, S., Sarode, S. C., Gadbail, A. R., Yuwanati, M., Sarode, G. S., Gondivkar, R. S., & Awan, K. H. Oro-facial opportunistic infections and related pathologies in HIV patients: A comprehensive review. Disease-a-Month, 2021; 101170. https://doi.org/10.1016/j.disamonth.2021.101170 PMid:33618831

World Health Organization. Updated recommendations on first-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV: interim guidelines: supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection (No. WHO/CDS/HIV/18.51). World Health Organization. 2018

Scorza, P., Merz, E. C., Spann, M., Steinberg, E., Feng, T., Lee, S., ... & Monk, C. Pregnancy-specific stress and sensitive caregiving during the transition to motherhood in adolescents. BMC Pregnancy and Childbirth, 2021 ;21(1), 1-8. https://doi.org/10.1186/s12884-021-03903-5 PMid:34187393 PMCid:PMC8243904

World Health Organization. Consolidated guideline on sexual and reproductive health and rights of women living with HIV. World Health Organization. 2017

Slavin, H. Improving health and social well-being. Higher Education and International Capacity Building: Twenty-Five Years of Higher Education Links, 2009 ;79-94.

Mikyas, Y., Aziz, N., Harawa, N., Gorre, M., Neagos, N., Nogueira, M., ... & Plaeger, S. Immunologic activation during pregnancy: serial measurement of lymphocyte phenotype and serum activation molecules in HIV-infected and uninfected women. Journal of Reproductive Immunology, 1997 ;33(2), 157-170. https://doi.org/10.1016/S0165-0378(97)00018-1 PMid:9234214

Ahdieh, L. Pregnancy and infection with human immunodeficiency virus. Clinical Obstetrics and Gynecology, 2001; 44(2), 154-166. https://doi.org/10.1097/00003081-200106000-00006 PMid:11344985

Ekouevi, D. K., Inwoley, A., Tonwe-Gold, B., Danel, C., Becquet, R., Viho, I., ... & Leroy, V. Variation of CD4 count and percentage during pregnancy and after delivery: implications for HAART initiation in resource-limited settings. AIDS research and human retroviruses, 2007 ;23(12), 1469-1474. https://doi.org/10.1089/aid.2007.0059 PMid:18160003

Hel Z, McGhee JR, Mestecky J. HIV infection: first battle decides the war. Trends Immunol. 2006;27(6):274-281. https://doi.org/10.1016/j.it.2006.04.007 PMid:16679064

Zuckerman AJ, Banatvala JE, Griffiths P, Schoub B, Mortimer P, editors. Principles and Practice of Clinical Virology. 6th ed. Hoboken, NJ: John Wiley and Sons Ltd; 2009. https://doi.org/10.1002/9780470741405

Brettle, R. P., Raab, G. M., Ross, A., Fielding, K. L., Gore, S. M., & Bird, A. G. HIV infection in women: immunological markers and the influence of pregnancy. AIDS (London, England), 1995; 9(10), 1177-1184. https://doi.org/10.1097/00002030-199510000-00010 PMid:8519455

BRANCH, D. W. Physiologic adaptations of pregnancy. American Journal of Reproductive Immunology, 1992 ;28(3‐4), 120-122. https://doi.org/10.1111/j.1600-0897.1992.tb00771.x PMid:1285859

Lindgren, S., Martin, C., Anzén, B., Strand, H., Bredberg-Rådén, U., & Ehrnst, A. Pattern of HIV viraemia and CD4 levels in relation to pregnancy in HIV-1 infected women. Scandinavian journal of infectious diseases, 1996; 28(5), 425-433. https://doi.org/10.3109/00365549609037933 PMid:8953667

Wang, B., Losina, E., Stark, R., Munro, A., Walensky, R. P., Wilke, M., ... & Wood, R. Loss to follow-up in a community clinic in South Africa-roles of gender, pregnancy and CD4 count. South African Medical Journal, 2011 ;101(4), 253-257. https://doi.org/10.7196/SAMJ.4078 PMid:21786730 PMCid:PMC3834586

Akinbami, A. A., Gbadegesin, A., Ajibola, S. O., Uche, E. I., Dosunmu, A. O., Adediran, A., & Sobande, A. Factors influencing CD4 cell count in HIV-positive pregnant women in a secondary health center in Lagos, Nigeria. Hiv/aids (Auckland, NZ), 2015; 7, 115. https://doi.org/10.2147/HIV.S80137 PMid:25914558 PMCid:PMC4401335

Mostad, S. B., Overbaugh, J., DeVange, D. M., Welch, M. J., Chohan, B., Mandaliya, K., ... & Kreiss, J. K. Hormonal contraception, vitamin A deficiency, and other risk factors for shedding of HIV-1 infected cells from the cervix and vagina. The Lancet, 1997;350(9082), 922-927. https://doi.org/10.1016/S0140-6736(97)04240-2 PMid:9314871

Published

15-05-2024
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How to Cite

1.
NTEZIRIZAZA E, Alain Prudence I, Habanabakize BJ, Jean De Dieu T. Evaluation of CD4 Count in HIV Infected Pregnant Women at Kibagabaga Level Two Teaching Hospital. J. Drug Delivery Ther. [Internet]. 2024 May 15 [cited 2025 Jan. 17];14(5):1-5. Available from: https://jddtonline.info/index.php/jddt/article/view/6513

How to Cite

1.
NTEZIRIZAZA E, Alain Prudence I, Habanabakize BJ, Jean De Dieu T. Evaluation of CD4 Count in HIV Infected Pregnant Women at Kibagabaga Level Two Teaching Hospital. J. Drug Delivery Ther. [Internet]. 2024 May 15 [cited 2025 Jan. 17];14(5):1-5. Available from: https://jddtonline.info/index.php/jddt/article/view/6513

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