Evaluation of Anti-depressant Activity of Ethanolic Extract of Moringa oleifera Leaves in Mice
Abstract
The use of Moringa oleifera in the food preparations can help to meet the future demands of nutraceuticals and functional foods. The present work is aimed to evaluate the antidepressant activity of ethanolic extract of Moringa oleifera Leaves (EEMOL) in mice. The overnight fasted mice will be divided into 04 groups, each group consisting of 06 animals. The EEMOL will be given in various doses (10, 100, 500 and 1000 mg/kg ) by oral route with a gavage. After administration of the extract, the animal will be observed continuously for the first 2 hours and at 24 hrs to detect changes in behavioral responses and also for tremors, convulsion, salivation, diarrhea, lethargy, sleep, and coma and also will be monitored up to 14 days for the toxic symptoms and mortality. The mice of Moringa oleifera extract (300 & 600 mg/kg/p.o) treated group showed significantly (p<0.05) increased in body weight, feed intake and body water intake as compared to the control group. Treatment with Fluoxetine (10 mg/kg p.o.) the body weight, feed intake and body water intake significantly increased as compared to normal group. The observation of this study suggests that Moringa Oleifera has antidepressant activity. In conclusion, Moringa oleifera extracts possess a broad spectrum of activity against a panel of factors responsible for the most common psychosis diseases.
Keywords: Anti-depressant Activity, Ethanolic Extract of Moringa oleifera Leaves, Fluoxetine
Keywords:
Anti-depressant Activity, Ethanolic Extract of Moringa oleifera Leaves, FluoxetineDOI
https://doi.org/10.22270/jddt.v14i12.6874References
1. Rang HP, Dale MM, Ritter JM, RJ. Pharmacology. London: Churchill Livingstone Elsevier;2008
2. World Health Organization, World suicide prevention day 2012. http://www.who.int/mediacentre/events/annual/world_suicide_prevention_day/en/ Accessed 16.6.2012
3. Wessling A, Joakim R, "The review of antidepressants De¬pression" 1st ed. Sweden: Dental and Pharmaceutical Benefits agency, 2008;1-112.
4. Dhakar RC, Maurya SD, Pooniya BK, Bairwa N, Gupta M, Moringa: The Herbal Gold to Combat Malnutrition, Chronicles of Young Scientists, 2011;2(3):119-125. https://doi.org/10.4103/2229-5186.90887
5. Anwar F, Latif S, Ashraf M, Gilani AH "Moringa oleifera: A food plant with multiple medicinal uses" Phytother, 2007;21:17-25. https://doi.org/10.1002/ptr.2023 PMid:17089328
6. Kalaimathi RV, Krishnaveni K, Murugan M, Basha AN, Gilles AP, Kandeepan C, Senthilkumar N, Mathialagan B, Ramya S, Ramanathan L, Jayakumararaj R, Loganathan T, Pandiarajan G, Dhakar RC, ADMET informatics of Tetradecanoic acid (Myristic Acid) from ethyl acetate fraction of Moringa oleifera leaves, Journal of Drug Delivery and Therapeutics. 2022;12(4-S):101-111 https://doi.org/10.22270/jddt.v12i4-S.5533
7. Dilard CJ, German JB "Phytochemicals: nutraceuticals and human health: a Review" J Sci Food Agric, 2000;80:1744-56. https://doi.org/10.1002/1097-0010(20000915)80:12<1744::AID-JSFA725>3.0.CO;2-W
8. The Organization of Economic Co-Operation and Development (OECD). The OECD Guideline for Testing of Chemicals: 423 Acute Oral Toxicity, OECD, Paris 2001; 1-14.
9. Sofowora, A "Screening Plants for Bioactive Agents. In: Medicinal Plants and Traditional Medicinal in Africa" 2nd Ed. Spectrum Books Ltd, Sunshine House, Ibadan, Nigeria, 1993;134-156.
10. Roy, M., David, N., Cueva, M. and Giorgetti, M "A study of the involvement of melaninconcentrating hormone receptor 1 (MCHR1) in murine models of depression" Biological Psychiatry, 2007;61:174-180. https://doi.org/10.1016/j.biopsych.2006.03.076 PMid:16934771
11. Stdru L, Thierry B, Chermat R, Simon P "Animal modeling of depression: an ethological approach and its relevance to psychopharmacology" Presented at the 13th CINP Congress, Jerusalem, Israel, 1982;20-25:694
12. Trease, G.E. and Evans, W.C. "Pharmacognosy" Saunders Publishers, London. 2002;15:42-44, 221-229, 246-249, 304-306, 331-332, 391-393
Published
Abstract Display: 546 
PDF Downloads: 352 PDF Downloads: 162 How to Cite
Issue
Section
Copyright (c) 2024 Subham , Ritu Rani , Ajeet Pal Singh , Amar Pal Singh
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.