Exploring Neuroprotective Botanical Remedies in Neurodegenerative Conditions: A Review

  • Ankit Sharma Research Scholar, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India. https://orcid.org/0009-0009-8120-0197
  • Meenakshi Malhotra Associate professor, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India. https://orcid.org/0000-0002-0080-1479
  • Amar Pal Singh Associate professor, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India. https://orcid.org/0000-0003-0027-2869
  • Ajeet Pal Singh Academic Dean and Associate professor, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India. https://orcid.org/0000-0002-1212-5770

Abstract

Neuroprotection refers to the mechanisms and strategies used to protect the Central Nervous System (CNS) from neuronal injuries caused by neurodegenerative disorders. Neurodegenerative disorders are a type of chronic condition in which parts of the nervous system deteriorate over time, most notably the brain. These disorders have a slow and gradual effect on an individual. Neurodegeneration is a neuropathological condition and brain aging process. The brain pathology of neurodegenerative and cerebrovascular disease is a leading cause of death worldwide, with a death rate of approximately 8% and an incidence rate of approximately 2/1000. It is a major health issue in the twenty-first century. According to researchers, this disease affects over 50 million people worldwide. These disorders primarily affect people over the age of 65, and the World Health Organization predicts that this number will more than double in the next 30 years. Confusion, difficulty thinking, pain, muscle spasms, behavioral changes, paralysis, tremors, balance problems, coordination issues, hunched posture, and fatigue are symptoms of these disorders. These disorders are caused by age, genetics, medical history, habits, routine, and environment. This review article is focused on herbs such as Crocus sativus and Curcuma longa which are very helpful in Neurodegenerative diseases and serve as a resource for future research.


Keywords: Neurodegeneration, Medicinal Herbs, Neuroprotection, Neuroprotective plants, Parkinson, Alzheimer.

Keywords: Neurodegeneration, Medicinal Herbs, Neuroprotection, Neuroprotective plants, Parkinson, Alzheimer

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Author Biographies

Ankit Sharma, Research Scholar, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India.

Research Scholar, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India.

Meenakshi Malhotra, Associate professor, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India.

Associate professor, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India.

Amar Pal Singh, Associate professor, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India.

Associate professor, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India.

Ajeet Pal Singh, Academic Dean and Associate professor, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India.

Academic Dean and Associate professor, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT(R.E.C.), Jalandhar-Amritsar bypass NH-1 jalandhar-144011, Punjab, India.

References

1. Neurodegenerative Diseases: What They Are & Types. Accessed February 10, 2024. https://my.clevelandclinic.org/health/diseases/24976-neurodegenerative-diseases
2. Kumar GP, Khanum F. Neuroprotective potential of phytochemicals. Pharmacogn Rev. 2012;6(12):81-90. https://doi.org/10.4103/0973-7847.99898 PMid:23055633 PMCid:PMC3459459
3. Gitler AD, Dhillon P, Shorter J. Neurodegenerative disease: Models, mechanisms, and a new hope. DMM Dis Model Mech. 2017;10(5):499-502. https://doi.org/10.1242/dmm.030205 PMid:28468935 PMCid:PMC5451177
4. Roy S, Awasthi H. Herbal Medicines As Neuroprotective Agent: a Mechanistic Approach. Int J Pharm Pharm Sci. 2017;9(10):1. https://doi.org/10.22159/ijpps.2017v9i11.19444
5. Malík M, Tlustoš P. Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs. Nutrients. 2022;14(16). https://doi.org/10.3390/nu14163367 PMid:36014874 PMCid:PMC9415189
6. Sangma JM, Nagalakshmi NC, Kurbah S. A REVIEW ARTICLE ON MEDICINAL HERBS HAVING NEUROPROTECTIVE PROPERTIES. 2022;(5):110-117.
7. Anjali Divatankar AMB, Babar AS, Payghan SA, Harshad RD, Dhudhane MS, Chhalwadi MS. Natural Plant Herbs Used As Neuroprotective Agent. Int J Creat Res Thoughts. 2021;9(5):2320-2882. www.ijcrt.org
8. Soria Lopez JA, González HM, Léger GC. Alzheimer's disease. Handb Clin Neurol. 2019;167:231-255. https://doi.org/10.1016/B978-0-12-804766-8.00013-3 PMid:31753135
9. Lane CA, Hardy J, Schott JM. Alzheimer's disease. Eur J Neurol. 2018;25(1):59-70. https://doi.org/10.1111/ene.13439 PMid:28872215
10. Simon DK, Tanner CM, Brundin P. Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology. Clin Geriatr Med. 2020;36(1):1-12. https://doi.org/10.1016/j.cger.2019.08.002 PMid:31733690 PMCid:PMC6905381
11. Ghosh R, Tabrizi SJ. Huntington Disease. Vol 147. 1st ed. Elsevier B.V.; 2018. https://doi.org/10.1016/B978-0-444-63233-3.00017-8 PMid:29325616
12. Hardiman O, Al-Chalabi A, Chio A, et al. Amyotrophic lateral sclerosis. Nat Rev Dis Prim. 2017;3. https://doi.org/10.1038/nrdp.2017.71 PMid:28980624
13. Mzabri I, Addi M, Berrichi A. Traditional and modern uses of saffron (Crocus sativus). Cosmetics. 2019;6(4):1-11. https://doi.org/10.3390/cosmetics6040063
14. Srivastava R, Ahmed H, Dixit R, Dharamveer, Saraf S. Crocus sativus L.: A comprehensive review. Pharmacogn Rev. 2010;4(8):200-208. https://doi.org/10.4103/0973-7847.70919 PMid:22228962 PMCid:PMC3249922
15. Begum S, Mannan A, A review on nigella sativa: a marvel herb, Journal of Drug Delivery and Therapeutics. 2020;10(2):213-219. https://doi.org/10.22270/jddt.v10i2.3913
16. Khazdair MR, Anaeigoudari A, Hashemzehi M, Mohebbati R. Neuroprotective potency of some spice herbs, a literature review. J Tradit Complement Med. 2019;9(2):98-105. https://doi.org/10.1016/j.jtcme.2018.01.002 PMid:30963044 PMCid:PMC6435951
17. Mannangatti P, Naidu KN. Indian herbs for the treatment of neurodegenerative disease. Adv Neurobiol. 2016;12:323-336. https://doi.org/10.1007/978-3-319-28383-8_17 PMid:27651261
18. L NK, Bhattacharjee A. Medicinal Herbs As Neuroprotective Agents. Certif J │ 675 Naveen al World J Pharm Pharm Sci WORLD J Pharm Pharm Sci SJIF Impact Factor. 2015;10(4):675-689. https://doi.org/10.17605/OSF.IO/WYPSR
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Sharma A, Malhotra M, Singh AP, Singh AP. Exploring Neuroprotective Botanical Remedies in Neurodegenerative Conditions: A Review. JDDT [Internet]. 15May2024 [cited 17May2024];14(5):137-40. Available from: https://jddtonline.info/index.php/jddt/article/view/6544