Pharmacological Evaluation of Anti-depressant activity of Aegle Marmelos ethanolic leaves extract in mice
Abstract
Bael (A. marmelos) is an important medicinal herb which has been and extensively used in Ayurveda, Siddha and other medicinal systems. The aim of this study is to evaluate the pharmacological activity of leaves part of the plant Aegle marmelos. Ethanolic extract of Aegle marmelos leaves prepared by successive extraction technique. This research carroed out to find out the Percentage Yield of Extract of Aegle marmelos, determination of LD50 of the EEAML as per OECD guidelines and to investigate the anti-depressant effect of Aegle marmelos leaves extract using tail suspension test (TST) and forced swim test (FST) parameters at dose levels of 200 mg/kg and 400 mg/kg respectively in albino swiss mice. Aegle marmelos leaves extract showed significant antidepressant activity probably due to GABA facilitatory action of phytoconstituents such as flavonoids, tannic acid, marmesinin, phenols, saponin etc. Results suggested that cortisol and corticosterone responded differently to severe stressors with cortisol being a quicker responder than corticosterone.
Keywords: Aegle Marmelos, phytoconstituents, Anti-depressant activity
Keywords:
Aegle Marmelos, phytoconstituents, Anti-depressant activity, Aegle Marmelos, phytoconstituents, Anti-depressant activityDOI
https://doi.org/10.22270/jddt.v15i1.6922References
1. Rang HP, Dale MM, Ritter JM, RJ. Pharmacology, 6th edition, Churchill Livingstone Elsevier; 2008
2. Craig CR, Stitzel RE. Modern Pharmacology and Clinical Applications. New York: Lippincott Williams and Willkins; 2009
3. Musselman DL, DeBattista C, Nathan KI. Biology of mood disorders. In: The American psychiatric press textbook of psychopharmacology. Schatzberg AF., Nemeroff CB, eds. Washington DC: American Psychiatric Press: 1998:549-88
4. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharm Exp Ther 1997;283:1305
5. Agrawal SS, Paridhavi M Herbal DrugTechnology, 1st edition, University Press, Hyderabad, 2007, 1-4.
6. Agarwal VS, Rural Economics of Medicinal Plants: Vegetation in the Forests, In: Drug Plants of India, vol. 1, Kalyani publishers, New Delhi, 1997, pp. 1,6,44,45,102,103,129,160.
7. Lomate KA, Murthy K, Adak VS, Shete RVV. A review on phytochemical and pharmacological values of Aegle marmelos. Journal of Drug Delivery and Therapeutics, 2021;11(2-S):162-166. https://doi.org/10.22270/jddt.v11i2-S.4645
8. Savita, Singh AP, Singh AP. Aegle marmelos (L.) (Bael): A Systematic Review. Journal of Drug Delivery and Therapeutics, 2021;11(3-S):131-136. https://doi.org/10.22270/jddt.v11i3-S.4834
9. Alka C, Meera A, Sonalika K, Anju M; Suppression of fertility in male albino rats following the administration of 50% ethanol extract of Aegle marmelos. NCBI, December 2007;76(6):474-481. https://doi.org/10.1016/j.contraception.2007.08.002 PMid:18061707
10. A Jaswanth, S. Sathya, S. Ramu, A. Puratchikody, and K. Ruckmani; Effect of root extract of Aegle marmelos on dermal wound healing in rats. Ancient Science of Life, 2001;XX(4):111-114.
11. Abhijit D, Neeta L, Musarrat N, Abhijeet G and Rupa V; Ethnological and Ethno-medicinal Importance of Aegle marmelos (L.) Corr (Bael) Among Indigenous People of India 2014; Vol. 1.
12. Amit P, Rashmi M; Antibacterial properties of Aegle marmelos leaves, fruits and peels against various pathogens. Journal of Pharmaceutical and Biomedical Sciences (JPBMS)2011; Vol. 13, Issue 13.
13. Dhankhar S, Ruhil S, Balhara M, Dhankhar S and Chhillar A.K; Aegle marmelos Correa: A PotentialSource of Phytomedicine. Journal of Medicinal plant Research 2011, 5(9):1497-1507.
14. Dinesh Kumar S, Gaurav Kumar, L. Karthik and K. V. Bhaskara Rao; A review on pharmacological and phytochemical properties of Aegle marmelos (L.) Corr. Serr. (Rutaceae) 2011.
15. Fouzia B, Jamal A, Nighat A, Shah A and Pawan K; Pharmacological investigations on Bael (Aegle Marmelos Linn.): A Unani medicinal plant; April 2018.
16. Handa, S. S. An Overview of Extraction Techniques for Medicinal and Aromatic Plants. Extraction Technologies For Medicinal And Aromatic Plants, United Nations Industrial Development Organization and The International Centre For Science and High Technology: Italy, 2008; p 11, 22-27.
17. Jarald, E. E.; Jarald, S. E. Textbook of Pharmacognosy and Phytochemistry; 1st ed.; CBS Publishers and Distributors Pvt. Ltd.: New Delhi, 2007; pp 104-105.
18. http://en.Wikipedia.org/wiki/Soxhlet/.
19. Kokate, C. K. Practical Pharmacognosy; 4th ed.; Vallabh Prakashan: Delhi, 1994; pp 107-109.
20. Ramya S, Chandran M, King IJ, Jayakumararaj R, Loganathan T, Pandiarajan G, Kaliraj P, Grace Lydial Pushpalatha G, Abraham GC, Vijaya V, Aruna D, Sutha S, Dhakar RC, Phytochemical Screening, GCMS and FTIR Profile of Bioactive Compounds in Solanum lycopersicum Wild Fruits collected from Palani Hill Ranges of the Western Ghats, Journal of Drug Delivery and Therapeutics. 2022;12(6):56-64 https://doi.org/10.22270/jddt.v12i6.5665
21. Kokate, C. K.; Purohit, A. P.; Gokhale, S. B. Pharmacognosy; 36th ed.; Nirali Prakashan: Pune, 2006; p 255.
22. Khandelwal KR. Practical Pharmacognosy-techniques and experiments.Pune; Nirali Prakashan; 2000
23. Kalaimathi RV, Krishnaveni K, Murugan M, Basha AN, Gilles AP, Kandeepan C, Senthilkumar N, Mathialagan B, Ramya S, Ramanathan L, Jayakumararaj R, Loganathan T, Pandiarajan G, Dhakar RC, ADMET informatics of Tetradecanoic acid (Myristic Acid) from ethyl acetate fraction of Moringa oleifera leaves, Journal of Drug Delivery and Therapeutics. 2022;12(4-S):101-111 https://doi.org/10.22270/jddt.v12i4-S.5533
24. Dunham NM, Miya TS, A note on simple apparatus for detecting Neurological deficit in rats and mice. J.Am. pharm(1957) 46,2089 https://doi.org/10.1002/jps.3030460322 PMid:13502156
25. Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl.). 1987; 92: 180-185. https://doi.org/10.1007/BF00177912
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Copyright (c) 2025 Mohit Arora , Ritu Rani , Ajeet Pal Singh , Amar Pal Singh

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