Pharmacological Evaluation of Anti-depressant activity of Aegle Marmelos ethanolic leaves extract in mice

Authors

  • Mohit Arora Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
  • Ritu Rani Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India. https://orcid.org/0009-0009-0013-6016
  • Ajeet Pal Singh Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India. https://orcid.org/0000-0002-1212-5770
  • Amar Pal Singh Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India. https://orcid.org/0000-0003-0027-2869

Abstract

Bael (A. marmelos) is an important medicinal herb which has been and extensively used in Ayurveda, Siddha and other medicinal systems. The aim of this study is to evaluate the pharmacological activity of leaves part of the plant Aegle marmelos. Ethanolic extract of Aegle marmelos leaves prepared by successive extraction technique. This research carroed out to find out the Percentage Yield of Extract of Aegle marmelos, determination of LD50 of the EEAML as per OECD guidelines and to investigate the anti-depressant effect of Aegle marmelos leaves extract using tail suspension test (TST) and forced swim test (FST) parameters at dose levels of 200 mg/kg and 400 mg/kg respectively in albino swiss mice. Aegle marmelos leaves extract showed significant antidepressant activity probably due to GABA facilitatory action of phytoconstituents such as flavonoids, tannic acid, marmesinin, phenols, saponin etc. Results suggested that cortisol and corticosterone responded differently to severe stressors with cortisol being a quicker responder than corticosterone.

Keywords: Aegle Marmelos, phytoconstituents, Anti-depressant activity

Keywords:

Aegle Marmelos, phytoconstituents, Anti-depressant activity, Aegle Marmelos, phytoconstituents, Anti-depressant activity

DOI

https://doi.org/10.22270/jddt.v15i1.6922

Author Biographies

Mohit Arora , Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Ritu Rani , Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Ajeet Pal Singh , Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Amar Pal Singh , Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

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Published

15-01-2025
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How to Cite

1.
Arora M, Rani R, Singh AP, Singh AP. Pharmacological Evaluation of Anti-depressant activity of Aegle Marmelos ethanolic leaves extract in mice. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 6];15(1):6-12. Available from: https://jddtonline.info/index.php/jddt/article/view/6922

How to Cite

1.
Arora M, Rani R, Singh AP, Singh AP. Pharmacological Evaluation of Anti-depressant activity of Aegle Marmelos ethanolic leaves extract in mice. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 6];15(1):6-12. Available from: https://jddtonline.info/index.php/jddt/article/view/6922

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