Antimicrobial Activity and Phytochemical analysis of Evolvulus alsinoides against HIV Secondary Pathogens
Abstract
Background: The antimicrobial activities of medicinal plants have long been exploited by scientific community against the diseases causing microorganisms. Routine use of antibiotic agents developed microbes as drug resistant organisms making it as a critical issue in case of treatments. So the detection of new natural compounds with antimicrobial activity is considered to be important. Although hundreds of plant species have been said to have antimicrobial properties, the vast majority have not been adequately evaluated. The present research works focus to develop new therapeutic agents or drug from selected medicinal plant of Evolvulus alsinoides against HIV Secondary pathogenic organisms, based on the review of literature, problems associated with treatment of pathogenic organisms and drug resistant patterns of the pathogenic organisms.
Results: The isolated bacterial cultures from secondary infection of HIV patient’s samples were identified as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa based on their Morphology, Staining, Motility and Biochemical test. The isolated fungal cultures were identified as, Aspergillus niger, Penicillium sp, Mucor sp, and Candida albicans, based on their growth and LCB staining. Evolvulus alsinoides has shown to have several compounds that play a great function in its antimicrobial activity.
Conclusion: There is a need to develop alternative agents for the control of pathogenic bacterial and fungal diseases in HIV infected persons. There is a good reason to support that the secondary metabolites of plants have evolved to protect them from attack by microbial pathogens. Hence, products from plants have great potential as sources of novel bioactive compounds for controlling pathogenic microorganisms. The treatment of various infectious diseases by the support of traditional usage of herbal medicine indicates the therapeutic potential of Evolvulus alsinoides by its antimicrobial activity. Further clinical studies are required to validate the efficacy of this medicinal plant against various pathogens and various resistant strains of bacteria.
Keywords: Evolvulus alsinoides, HIV Secondary Pathogens, Solvent extracts, antimicrobial activity, Phytochemical Analysis.
Keywords:
Evolvulus alsinoides, HIV Secondary Pathogens, Solvent extracts, antimicrobial activity, Phytochemical AnalysisDOI
https://doi.org/10.22270/jddt.v14i7.6452References
Robinson N.J., Silarug N., Surasiengsunk S., Auvert B., Hanenberg R., Two million HIV infections prevented in Thailand: estimate of the impact of increased condom use. XI International AIDS Conference, Vancouver,1996; [Abstract Mo. C904].
Holmes C.B., Losina E., Walensky R.P., Yazdanpanah Y., Freedberg K.A., Review of Human Immunodeficiency Virus type 1-related opportunistic infections in sub-Saharan Africa. Clin. Infect. Dis.2003; 36 (5): 656-662. https://doi.org/10.1086/367655 PMid:12594648
Van Wyk, B., Gericke, N. (Eds.) People's Plants: A Guide to Useful Plants of South Africa, first ed. Briza Publications, South Africa. 2000;10-12.
Kaplan J.E., Benson C., Holmes K.H., Guidelines for prevention and treatment of opportunistic infections in MMWR Recomm Rep. 2009;58(4):1-207.
Leclerq R. and Courvalin P. Resistance to glycopeptides in enterococci. Clin. Infect. Dis.1997; 24: 545-556. https://doi.org/10.1093/clind/24.4.545 PMid:9145724
Bhuyan D.J. and Barooah M.S. Evaluation of antifungal, antibacterial and Antioxidant activities of Amphineuron extensus, Hedyotis diffusa and Vitex negundo. Journal of Cell and Tissue Research. 2012;12 (3) 3343-3348.
Sethiya NK, Ashish Trivedi, Mayur B. Patel, and S. H. Mishra. Comparative pharmacognostical investigation on four ethanobotanicals traditionally used as Shankhpushpi in India . J Adv Pharm Technol Res. 2010;1(4): 388-395. https://doi.org/10.4103/0110-5558.76437 PMid:22247878 PMCid:PMC3255406
Gupta P, Akanksha, Siripurapu KB, Ahmad A, Palit G, Arora A, Maurya R. Anti-stress constituents of Evolvulus alsinoides: an ayurvedic crude drug . Chem Pharm Bull (Tokyo).2007;55(5):771-5. https://doi.org/10.1248/cpb.55.771 PMid:17473466
Gupta P, Sharma U, Gupta P, Siripurapu KB, Maurya R. Bioorg Med Chem. Evolvosides C-E, flavonol-4-O-triglycosides from Evolvulus alsinoides and their anti-stress activity. Bioorg Med Chem.2013; 1;21(5):1116-22. https://doi.org/10.1016/j.bmc.2012.12.040 PMid:23357036
Manmeet Kumar, Ausaf Ahmad, Preeti Rawat, Rakesh Maurya Kumar M, Antioxidant flavonoid glycosides from Evolvulus alsinoide. Fitoterapia. Fitoterapia.2010; 81(4):234-42 https://doi.org/10.1016/j.fitote.2009.09.003 PMid:19748554
Cervenka F, Jahodár L .Plant metabolites as nootropics and cognitives. Ceska Slov Farm.2006; 7454(2): 19-23.
Cervenka F, Koleckar V, Rehakova Z, Jahodar L, Kunes J, Opletal L, Hyspler R, Jun D, Kuca K. Evaluation of natural substances from Evolvulus alsinoides L. with the purpose of determining their antioxidant potency . J Enzyme Inhib Med Chem.2008;23(4):574-8. https://doi.org/10.1080/14756360701674421 PMid:18666003
Nahata A, and Dixit VK. Spectrofluorimetric Estimation of Scopoletin in Evolvulus alsinoides Linn. and Convulvulus pluricaulis Choisy . Indian J Pharm Sci. 2008;37(7): 23-28.
Evans W.C. and Trease G.E. A text book of Pharmacognosy. Bailliare Tindall and Cassel. 2008;14th ed., 2008, 13.
Rabe, T. S. J.Isolation of an Antimicrobial sesquiterpenoid from Warbugie salutaris. Journal of Ethnopharmacology.2000; 93:171- 174. https://doi.org/10.1016/S0378-8741(00)00293-2 PMid:11025153
Singh, I. & Singh, V., P. Antifungal properties of aqueous and organic solution extracts of seed plants against Aspergillus flavus and A. niger. Phytomorphol. 2000; 50: 151-157.
Kannan Elangovan, Kumar Supriya, Kandhasamy Murugesan and Rajamani Aravind Screening of Phytochemicals and In vitro Antioxidant activity of Evolvulus alsinoides L.. Journal of Academia and Industrial Research.2013; 2(4). 230-234.
Dhanalekshmi UM, Poovi G, Kishore N, Raja MD, Reddy PN. Evaluation of wound healing potential and antimicrobial activity of ethanolic extract of Evolvulus alsinoides. Annals of Biological Research 2010;1: 49-61.
Dash GK, Suresh P, Sahu SK, Kar DM, Ganapaty S, Evaluation of Evolvulus alsinoides Linn for anthelmintic and antimicrobial activities. Journal of Natural Remedies 2002;2: 182-185.
Natarajan, D., Britto J. S., Srinivasan, K., Nagamurugan, N., Mohanasundari, C. & Perumal, G. Antibacterial activity of Euphorbia fusiformis - a rare medicinal herb Journal of Ethnopharmacology.2005; 102: 123-126. https://doi.org/10.1016/j.jep.2005.04.023 PMid:16159702
Singh, I. & Singh, V., P. Antifungal properties of aqueous and organic solution extracts of seed plants against Aspergillus flavus and A. niger. Phytomorphol.2000; 50:151-157.
Vijayan MN, Ida B, Seema D, Shital D and Astrida R.. Antimicrobial activity of ten common herbs, commonly known as 'Dashapushpam' from Kerala, India. African Journal of Microbiology Research .2017;4(22):2357-2362
Gomathi RL and Elango V. In vitro antimicrobial activity and phytochemical analysis of few Indian medicinal plants. International Journal of Science and Research .2015;4(8):659-663
Published
Abstract Display: 198 
PDF Downloads: 132 PDF Downloads: 60 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.