Animals Use to Find Anxiolytic Activity: An Updated Review with Advantage of Each Model

Abstract

Anxiety affects both humans and animals in profound ways, and understanding its psychological and biological components is essential to the development of anxiolytic medications. Animal models are utilized as simulations to explain emotional activities and as screening tools in anxiety research. Rats are the animal model used most often; mice, a more genetically flexible mammal, do less well in animal models. Behavioral investigations need careful consideration of changeable characteristics related to handling, climate, or models. To help us better understand the neurobiological elements of anxiety, the most recent experimental anxiety models such as the elevated plus maze apparatus, light-dark model, open field apparatus, and hole board apparatus are being examined. Psychopharmacological disorders affect one in seven Indians; nevertheless, adverse effects include weight gain, cramping in the muscles, dysphoria, upset stomach, blurred vision, and issues with blood tests may occur. In order to improve our knowledge of the animal models used to determine the anxiolytic action in mice, we will talk about pertinent animal models that have been established in this article.

Keywords: Anxiolytic activity, Anxiety, Elevated zero maze, Plus maze, Elevated T maze, light and dark box model and Mirrored chamber, Animal models