Microsponge: A Review
Abstract
Microsponge are little spherical molecules with a broad porous surface that resemble sponges. The use of microsponges is a unique medication delivery method that has several benefits. For a range of illnesses, the Microsponges drug delivery system is utilized to improve the effectiveness of oral, parenteral, or topical medicine administration. A novel approach of managing drug release and administering medication to specific locations is microsponge technology. The efficient and novel way that microsponge medicine administration advances properties, boosts item stability, and improves security can all contribute to the effectiveness of topically dynamic operators.
In an effective and creative way, it can boost the efficiency of topically active medications while improving safety, product stability, and aesthetic qualities. Recently, microsponges, which are typically used topically, have also been employed for oral delivery. Microsponge Systems may suspend or trap a wide range of substances. They can also be integrated into a product that is made to resemble a gel, cream, liquid, or powder. Microsponge Systems are built on atomic, polymer-based microspheres. In topical medication solutions, microsponge technology has been employed to provide controlled release of active drug into the skin, therefore decreasing systemic exposure and local cutaneous responses to active pharmaceuticals. We will talk about microsponge's characteristics, benefits, and drawbacks as well as the drug release mechanism, formulation techniques, and assessment in this review paper.
Keywords: Microsponge, NDDS, Novel drug delivery system, MDS
Keywords:
Microsponge, NDDS, Novel drug delivery system, MDSDOI
https://doi.org/10.22270/jddt.v14i6.6620References
Khule P K, Nitalikar M M, More V V, Gilhotra R M, "MICROSPONGE DRUG DELIVERY: A REVIEW", SGVU Journal of Pharmaceutical Research & Education, 2019, 4(1):359-365.
Mahrous R., Elosaily G.H., Khafazy E.S., Mostafa Y., Gad S. , Drug delivery of microsponges: A review article, Records of Pharmaceutical and Biomedical sciences, 2021;5(3):21-27. https://doi.org/10.21608/rpbs.2020.23585.1054
Gidde N , Karande K, Jadhav S, Mistry R, Mhetre P , Joshi S . "Microsponge : An Overview". Journal of University of Shanghai for Science and Technology. 2021;23:671-682. https://doi.org/10.51201/JUSST/21/11949
Murkute P K, Deokar R M, Salve M T, "A BRIEF REVIEW ON MICROSPONGES DRUG DELIVERY SYSTEM", World Journal of Pharmaceutical Research, 2023;12(21): 391-409.
Chadawar V., Shaji J. Microsponge delivery system. Curr Drug Deliv 2007; 4(2):123-9. https://doi.org/10.2174/156720107780362320 PMid:17456031
Jadhav N., Vruti P., Siddesh M., Gaurav B., Manisha K., Microsponge delivery system: an updated review, current status and future prospects, Journal of Scientific and Innovative Research 2013; 2(6):1097-1110.
Embil K., Nacht S. The microsponge ® delivery system (MDS): A topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives, Journal of microencapsulation1996; 13(5): 575-588. https://doi.org/10.3109/02652049609026042 PMid:8864994
Nacht S., Katz M. The Microsponge: A Novel Topical Programmable Delivery System, Drugs and the pharmaceutical sciences 1990; 42: 299-325. https://doi.org/10.1201/b14194-19
Borawake P. D., Kauslya A., Shinde J.V., Chavan R.S., Microsponge as an Emerging Technique in Novel Drug Delivery System, Journal of Drug Delivery and Therapeutics. 2021; 11(1):171-181 https://doi.org/10.22270/jddt.v11i1.4492
Aeila, Arjun Sai Sreekar. (2020). Microsponges -A Review on its Applications in Topical Sustained Drug delivery, 10.13140/RG.2.2.16502.75848.
Aritomi H, Yamada K, Honda H, Koshi M. Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. J Pharm Sci Technol 1996; 56(1):49-56.
D'souza J.I., Masvekar R.R., Pattekari P.P., Pudi S.R., More H.N. Microspongic delivery of fluconazole for topical application. IndoJapanese Int Conf Adv Pharm Res Technol 2004; 456:76-81.
Partibhan K.G., Manivannan R. Krishnarajan D., Chandra S., Raj N. Microsponges role in Novel drug delivery, Int J Pharm Res Dev 2011;3(4):117-1258.
Aloorkar N., Kulkarni A.s., Ingale D.J., Patil R.A. Microsponges as innovative drug delivery systems. Int J Pharm Sci Nanotechnol2012; 5(1):1597-1606. https://doi.org/10.37285/ijpsn.2012.5.1.2
D'souza J.I., More H.N. Topical anti-inflammatory gels of fluocinolone acetonide entrapped in eudragit based microsponge delivery system. Res J Pharm Tech 2008; 1(4):502-506.
Mahant S., Kumar S., Nanda S., Rao R., Microsponges for dermatological applications: Perspectives and challenges, Asian Journal of Pharmaceutical Sciences, 2020;15:273-291. https://doi.org/10.1016/j.ajps.2019.05.004 PMid:32636947 PMCid:PMC7327759
Dhakar RC, Maurya SD, Saluja V, From formulation variables to drug entrapment efficiency of microspheres: a technical review. Journal of Drug Delivery and Therapeutics, 2012;2(6):128-133. https://doi.org/10.22270/jddt.v2i6.160
Brunton L. L., Lazo J. S., Parker K. L. ,Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th ed., Vol. 2. New York: McGraw-Hill; 2006; 1021-7.
Vikrant K., James S., Anne J. and Manish S.K. Microparticles: A novel approach to enhance the drug delivery. Int J Pharm Res Dev 2011; 3(8):170-83.
Kilicarslan M., Baykara T., The effect of drug & polymer ratio on the properties of the Verapamil hydrochloride loaded microspheres, Int J Pharm 2003; 252:99-109. https://doi.org/10.1016/S0378-5173(02)00630-0 PMid:12550785
Mine O., Erdal C., Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges, Int J of Pharm 2006; 318:103-117. https://doi.org/10.1016/j.ijpharm.2006.03.025 PMid:16687222
Martin A., Swarbrick J., Cammarrata A. In: Physical Pharmacy & Physical Chemical Principles in Pharmaceutical Sciences, Vol 3, New Delhi, India: B. I. Waverly. 1991; 527-36
Tiwari A., Tiwari V., Palaria B., Kumar M., Kaushik B., Microsponges: a breakthrough tool in pharmaceutical research, Future Journal of Pharmaceutical Sciences 2022;8:31 https://doi.org/10.1186/s43094-022-00421-9
Garg A, Sharma G S, Goyal A K, Ghosh G, Si S C, Heliyon Recent advances in topical carriers of anti-fungal agents,2020;6(8) :1-12. doi: https://doi.org/10.1016/j.heliyon.2020.e04663 PMid:32904164 PMCid:PMC7452444
Vishwakarma P., Choudhary R., Microsponges: A Novel Strategy to Control the Delivery Rate of Active Agents with Reduced Skin Irritancy, Journal of Drug Delivery and Therapeutics. 2019; 9(6- s):238-247. https://doi.org/10.22270/jddt.v9i6-s.3757
Published
Abstract Display: 170 
PDF Downloads: 136 PDF Downloads: 114 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.