Formulation and In Vitro Evaluation of Bilayer Tablets of Lansoprazole and Amoxycillin Trihydrate for the Treatment of Peptic Ulcer

  • Neha Singh Sagar Institute of Research & Technology-Pharmacy, Ayodhya Bypass Road, Bhopal, M.P. India – 462041
  • Durga Pandey Sagar Institute of Research & Technology-Pharmacy, Ayodhya Bypass Road, Bhopal, M.P. India – 462041
  • Nilesh Jain Sagar Institute of Research Technology & Science-Pharmacy, Near ISRO, Bhopal, M.P. India – 462041
  • Surendra Jain Sagar Institute of Research & Technology-Pharmacy, Ayodhya Bypass Road, Bhopal, M.P. India – 462041

Abstract

The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lansoprazole in the immediate release layer and Amoxycillin in the sustained release layer, using sodium starch glycolate as a super disintegrant for the immediate release layer and the hydrophilic matrix HPMC K100M, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Bilayer tablet showed as initial burst effect to provide dose of immediate release layer Lansoprazole to control the acid secretion level and the sustained release of Amoxycillin for 24 hours. Immediate and sustained release tablets were formulated by wet granulation method because of the poor flow property of the blends. The prepared bilayer tablet was evaluated for their precompression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, In-vitro floating studies and In-vitro drug release. The release of the lansoprazole from the immediate release layer was found to be 97.46 ± 0.15% in 15minutes. The release of Amoxycillin Trihydrate for the sustained release floating layer was found to be 98.25 ± 0.14% in 12 hours. Lansoprazole potentiate the effect of Amoxycillin. Hence the bilayer tablets of Lansoprazole and Amoxycillin were used to improve patient compliance towards the effective management of ulcer.


Keywords: bilayer tablet, Lansoprazole, and Amoxycillin, sustained release

Keywords: bilayer tablet, Lansoprazole, Amoxycillin, sustained release

Downloads

Download data is not yet available.

Author Biographies

Neha Singh, Sagar Institute of Research & Technology-Pharmacy, Ayodhya Bypass Road, Bhopal, M.P. India – 462041

Sagar Institute of Research & Technology-Pharmacy, Ayodhya Bypass Road, Bhopal, M.P. India – 462041

Durga Pandey, Sagar Institute of Research & Technology-Pharmacy, Ayodhya Bypass Road, Bhopal, M.P. India – 462041

Sagar Institute of Research & Technology-Pharmacy, Ayodhya Bypass Road, Bhopal, M.P. India – 462041

Nilesh Jain, Sagar Institute of Research Technology & Science-Pharmacy, Near ISRO, Bhopal, M.P. India – 462041

Sagar Institute of Research Technology & Science-Pharmacy, Near ISRO, Bhopal, M.P. India – 462041

Surendra Jain, Sagar Institute of Research & Technology-Pharmacy, Ayodhya Bypass Road, Bhopal, M.P. India – 462041

Sagar Institute of Research & Technology-Pharmacy, Ayodhya Bypass Road, Bhopal, M.P. India – 462041

References

1. Matheson AJ, Jarvis B. Lansoprazole. Drugs. 2001; 61(12):1801-33.
2. Bown RL. An overview of the pharmacology, efficacy, safety and cost-effectiveness of lansoprazole. International journal of clinical practice. 2002; 56(2):132-9.
3. Nakao M, Malfertheiner P. Growth inhibitory and bactericidal activities of lansoprazole compared with those of omeprazole and pantoprazole against Helicobacter pylori. Helicobacter. 1998; 3(1):21-7.
4. Korolkovas, A. Essentials of Medicinal Chemistry, 2nd ed., New York: Wiley-Interscience. 1988; 1216.
5. Devani MB, Patel IT, Patel TM. Spectrophotometric determination of amoxycillin and its dosage forms. Journal of pharmaceutical and biomedical analysis. 1992; 10(5):355-8.
6. Bird AE. Amoxicillin. InAnalytical profiles of drug substances and excipients 1994; 23: 1-52.
7. Carceles CM, Escudero E, Vicente MS, Serrano JM, Carli S. Pharmacokinetics of amoxicillin/clavulanic acid combination after intravenous and oral administration in goats. Veterinary Quarterly. 1995; 17(4):134-8.
8. Pasqualoto KF, Funck JA, Silva FE, Kratz C. Development and Evaluation of Amoxicillin Formulations by Direct Compression: Influence of the Adjuvants on Physicomechanical and Biopharmaceutical Properties of the Tablets. Acta Farmaceutica Bonaerense. 2005; 24(1):39-47
9. Westphal JF, Deslandes A, Brogard JM, Carbon C. Reappraisal of amoxycillin absorption kinetics. Journal of antimicrobial chemotherapy. 1991; 27(5):647-54.
10. Kumar AH, Kavitha K, Kumar SA, Kumar MR, Singh SD. Novel Approach of bilayer tablet technology-a review. International journal of pharmaceutical, Chemical & Biological Sciences. 2013; 3(3):887- 893
11. Lopes CM, Lobo JM, Pinto JF, Costa PC. Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen. Aaps Pharmscitech. 2007; 8(3):195-202.
12. Maggi L, Machiste EO, Torre ML, Conte U. Formulation of biphasic release tablets containing slightly soluble drugs. European journal of pharmaceutics and biopharmaceutics. 1999; 48(1):37-42.
13. Lieberman HA, Lachman L, Schwarz JB. Pharmaceutical dosage forms: Tablets. New York and Basel.: Marcel Dekker, 1989, 2:1-54.
14. Beckett AH, Stenlake JB. Practical Pharmaceutical Chemistry, part-II. CBS Publications and Distributors, New Delhi. 1997; 1:275-320.
15. Vinod KR, Sri AP, Banji D, Anbazhagan S, Vasa S, Sandhya S. Formulation and in vitro characterization of lansoprazole floating gastroretentive microspheres by modified non aqueous solvent evaporation method. Der Pharma Chemica. 2010; 2(5):500-6.
Statistics
169 Views | 250 Downloads
How to Cite
1.
Singh N, Pandey D, Jain N, Jain S. Formulation and In Vitro Evaluation of Bilayer Tablets of Lansoprazole and Amoxycillin Trihydrate for the Treatment of Peptic Ulcer. JDDT [Internet]. 15Jan.2021 [cited 28Sep.2021];11(1):23-1. Available from: https://jddtonline.info/index.php/jddt/article/view/4481