Sexually Transmitted Diseases: An Overview of Common Diseases, Diagnosis and Treatment

Authors

  • Prafull S. Dhoke Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India.
  • Prashant G. Shelke Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India.
  • Pooja R. Hatwar Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India. https://orcid.org/0000-0002-5424-3425
  • Ravindra L. Bakal Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India. https://orcid.org/0000-0002-4964-4654

Abstract

Sexually transmitted diseases (STDs) are a significant global health concern, affecting millions of people worldwide. These diseases can lead to serious health complications, including infertility, cancer, and pregnancy problems. The most common STDs include gonorrhea, syphilis, chlamydia, trichomoniasis, and HIV. This review highlights the current state of STDs, their symptoms, diagnosis, treatment options, and prevention strategies. This article explores the causes, transmission, and effects of each disease, as well as the importance of early diagnosis and treatment. The review also explores the challenges in treating STDs, including antibiotic resistance and the need for effective prevention strategies. Understanding STDs is crucial for developing effective prevention and treatment programs, and this review aims to provide a comprehensive overview of the current state of STDs.

Keywords: gonorrhea, syphilis, trichomoniasis, chlymadia, HIV.

Keywords:

gonorrhea, syphilis, trichomoniasis, chlymadia, HIV

DOI

https://doi.org/10.22270/jddt.v15i6.7228

Author Biographies

Prafull S. Dhoke , Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India.

Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India.

Prashant G. Shelke, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India.

Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India.

Pooja R. Hatwar , Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India.

Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India.

Ravindra L. Bakal , Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India.

Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangaon Rly, Dist -Amravati (444709) Maharashtra, India.

References

1. Elendu C, Amaechi DC, Elendu ID, Elendu TC, Amaechi EC, Usoro EU, Chima-Ogbuiyi NL, Agbor DB, Onwuegbule CJ, Afolayan EF, Balogun BB. Global perspectives on the burden of sexually transmitted diseases: A narrative review. Medicine. 2024; 103(20): 38199. https://doi.org/10.1097/MD.0000000000038199 PMid:38758874 PMCid:PMC11098264

2. Sharifi-Rad J, Quispe C, Rahavian A, Pereira Carneiro JN, Rocha JE, Alves Borges Leal AL, Bezerra Morais Braga MF, Melo Coutinho HD, Ansari Djafari A, Alarcón-Zapata P, Martorell M. Bioactive compounds as potential agents for sexually transmitted diseases management: a review to explore molecular mechanisms of action. Frontiers in Pharmacology. 2021; 12:674682. https://doi.org/10.3389/fphar.2021.674682 PMid:34504422 PMCid:PMC8421529

3. Thng CC. A review of sexually transmitted infections in Australia-considerations in 2018. Academic forensic pathology. 2018; 8(4):938-46. https://doi.org/10.1177/1925362118821492 PMid:31240082 PMCid:PMC6491534

4. Samkange-Zeeb FN, Spallek L, Zeeb H. Awareness and knowledge of sexually transmitted diseases (STDs) among school-going adolescents in Europe: a systematic review of published literature. BMC public health. 2011; 11:1-2. https://doi.org/10.1186/1471-2458-11-727 PMid:21943100 PMCid:PMC3189891

5. Jolly AM, Muth SQ, Wylie JL, Potterat JJ. Sexual networks and sexually transmitted infections: a tale of two cities. Journal of Urban Health. 2001; 78:433-45. https://doi.org/10.1093/jurban/78.3.433 PMid:11564847 PMCid:PMC3455915

6. Van Gerwen OT, Muzny CA, Marrazzo JM. Sexually transmitted infections and female reproductive health. Nature microbiology. 2022; 7(8):1116-26. https://doi.org/10.1038/s41564-022-01177-x PMid:35918418 PMCid:PMC9362696

7. Mayer KH, Venkatesh KK. Interactions of HIV, other sexually transmitted diseases, and genital tract inflammation facilitating local pathogen transmission and acquisition. American journal of reproductive immunology. 2011; 65(3):308-16. https://doi.org/10.1111/j.1600-0897.2010.00942.x PMid:21214660 PMCid:PMC3077541

8. https://images.app.goo.gl/W6X4Sk4SE47WjKif6

9. Ochsendorf FR. Sexually transmitted infections: impact on male fertility. Andrologia. 2008; 40(2):72-5. https://doi.org/10.1111/j.1439-0272.2007.00825.x PMid:18336453

10. Workowski KA. Centers for Disease Control and Prevention sexually transmitted diseases treatment guidelines. Clinical Infectious Diseases. 2015; 61(8):759-62. https://doi.org/10.1093/cid/civ771 PMid:26602614

11. Seña AC, Hsu KK, Kellogg N, Girardet R, Christian CW, Linden J, Griffith W, Marchant A, Jenny C, Hammerschlag MR. Sexual assault and sexually transmitted infections in adults, adolescents, and children. Clinical infectious diseases. 2015; 61(8):856-64. https://doi.org/10.1093/cid/civ786 PMid:26602623

12. Assi R, Hashim PW, Reddy VB, Einarsdottir H, Longo WE. Sexually transmitted infections of the anus and rectum. World Journal of Gastroenterology: WJG. 2014; 20(41):15262. https://doi.org/10.3748/wjg.v20.i41.15262 PMid:25386074 PMCid:PMC4223259

13. Haese EC, Thai VC, Kahler CM. Vaccine candidates for the control and prevention of the sexually transmitted disease gonorrhea. Vaccines. 2021; 9(7):804. https://doi.org/10.3390/vaccines9070804 PMid:34358218 PMCid:PMC8310131

14. Ballini A, Cantore S, Fatone L, Montenegro V, De Vito D, Pettini F, Crincoli V, Antelmi A, Romita P, Rapone B, Miniello G. Transmission of nonviral sexually transmitted infections and oral sex. The Journal of Sexual Medicine. 2012; 9(2):372-84. https://doi.org/10.1111/j.1743-6109.2011.02515.x PMid:22023797

15. Gaydos C, Hardick J. Point of care diagnostics for sexually transmitted infections: perspectives and advances. Expert review of anti-infective therapy. 2014;12(6):657-72. https://doi.org/10.1586/14787210.2014.880651 PMid:24484215 PMCid:PMC4065592

16. Van Ommen CE, Malleson S, Grennan T. A practical approach to the diagnosis and management of chlamydia and gonorrhea. CMAJ. 2023; 195(24):844-9. https://doi.org/10.1503/cmaj.221849 PMid:37336564 PMCid:PMC10281205

17. Mayor MT, Roett MA, Uduhiri KA. Diagnosis and management of gonococcal infections. American family physician. 2012; 86(10):931-8

18. Tuddenham S, Hamill MM, Ghanem KG. Diagnosis and treatment of sexually transmitted infections: a review. Jama. 2022; 327(2):161-72 https://doi.org/10.1001/jama.2021.23487 PMid:35015033

19. Hughes G, Field N. The epidemiology of sexually transmitted infections in the UK: impact of behavior, services and interventions. Future microbiology. 2015; 10(1):35-51. https://doi.org/10.2217/fmb.14.110 PMid:25598336

20. Chun HM, Carpenter RJ, Macalino GE, Crum-Cianflone NF. The Role of Sexually Transmitted Infections in HIV‐1 Progression: A Comprehensive Review of the Literature. Journal of sexually transmitted diseases. 2013; 2013(1):176459. https://doi.org/10.1155/2013/176459 PMid:26316953 PMCid:PMC4437436

21. https://images.app.goo.gl/tDAeTTxKNTp8Ze1GA

22. Fuchs W, Brockmeyer NH. Sexually transmitted infections. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2014; 12(6):451-64. https://doi.org/10.1111/ddg.12310 PMid:24889293

23. Van Gerwen OT, Muzny CA, Marrazzo JM. Sexually transmitted infections and female reproductive health. Nature microbiology. 2022; 7(8):1116-26. https://doi.org/10.1038/s41564-022-01177-x PMid:35918418 PMCid:PMC9362696

24. Aral SO, Fenton KA, Holmes KK. Sexually transmitted diseases in the USA: temporal trends. Sexually transmitted infections. 2007; 83(4):257. https://doi.org/10.1136/sti.2007.026245 PMid:17664359 PMCid:PMC2598671

25. Hammerschlag MR, Guillén CD. Medical and legal implications of testing for sexually transmitted infections in children. Clinical microbiology reviews. 2010; 23(3):493-506. https://doi.org/10.1128/CMR.00024-09 PMid:20610820 PMCid:PMC2901660

26. Kenyon C, Herrmann B, Hughes G, de Vries HJ. Management of asymptomatic sexually transmitted infections in Europe: towards a differentiated, evidence-based approach. The Lancet Regional Health-Europe. 2023; 34. https://doi.org/10.1016/j.lanepe.2023.100743 PMid:37927435 PMCid:PMC10624996

27. Tucker JD, Bien CH, Peeling RW. Point-of-care testing for sexually transmitted infections: recent advances and implications for disease control. Current opinion in infectious diseases. 2013; 26(1):73-9. https://doi.org/10.1097/QCO.0b013e32835c21b0 PMid:23242343 PMCid:PMC3635142

28. Mathews C, Coetzee N, Zwarenstein M, Lombard C, Guttmacher S, Oxman A, Schmid G. A systematic review of strategies for partner notification for sexually transmitted diseases, including HIV/AIDS. International journal of STD & AIDS. 2002; 13(5):285-300. https://doi.org/10.1258/0956462021925081 PMid:11972932

29. Tsevat DG, Wiesenfeld HC, Parks C, Peipert JF. Sexually transmitted diseases and infertility. American journal of obstetrics and gynecology. 2017; 216(1):1-9. https://doi.org/10.1016/j.ajog.2016.08.008 PMid:28007229 PMCid:PMC5193130

30. Sadeghi-Nejad H, Wasserman M, Weidner W, Richardson D, Goldmeier D. Sexually transmitted diseases and sexual function. The journal of sexual medicine. 2010; 7:389-413. https://doi.org/10.1111/j.1743-6109.2009.01622.x PMid:20092446

31. Adams EJ, Charlett A, Edmunds WJ, Hughes G. Chlamydia trachomatis in the United Kingdom: a systematic review and analysis of prevalence studies. Sexually transmitted infections. 2004; 80(5):354-62. https://doi.org/10.1136/sti.2003.005454 PMid:15459402 PMCid:PMC1744901

32. Brunham RC, Rey-Ladino J. Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine. Nature reviews immunology. 2005; 5(2):149-61. https://doi.org/10.1038/nri1551 PMid:15688042

33. Smolarczyk K, Mlynarczyk-Bonikowska B, Rudnicka E, Szukiewicz D, Meczekalski B, Smolarczyk R, Pieta W. The impact of selected bacterial sexually transmitted diseases on pregnancy and female fertility. International journal of molecular sciences. 2021; 22(4):2170. https://doi.org/10.3390/ijms22042170 PMid:33671616 PMCid:PMC7926516

34. Elwell C, Mirrashidi K, Engel J. Chlamydia cell biology and pathogenesis. Nature Reviews Microbiology. 2016; 14(6):385-400. https://doi.org/10.1038/nrmicro.2016.30 PMid:27108705 PMCid:PMC4886739

35. Belland R, Ojcius DM, Byrne GI. Focus: chlamydia. Nature Reviews Microbiology. 2004; 2(7):530. https://doi.org/10.1038/nrmicro931 PMid:15248311

36. Taylor BD, Haggerty CL. Management of Chlamydia trachomatis genital tract infection: screening and treatment challenges. Infection and drug resistance. 2011 :19-29. https://doi.org/10.2147/IDR.S12715 PMid:21694906 PMCid:PMC3108753

37. O'Connell CM, Ferone ME. Chlamydia trachomatis genital infections. Microbial cell. 2016; 3(9):390. https://doi.org/10.15698/mic2016.09.525 PMid:28357377 PMCid:PMC5354567

38. Hou C, Jin Y, Wu H, Li P, Liu L, Zheng K, Wang C. Alternative strategies for Chlamydia treatment: Promising non-antibiotic approaches. Frontiers in microbiology. 2022; 13:987662. https://doi.org/10.3389/fmicb.2022.987662 PMid:36504792 PMCid:PMC9727249

39. Kuo CC, Jackson LA, Campbell LA, Grayston JT. Chlamydia pneumoniae (TWAR). Clinical microbiology reviews. 1995; 8(4):451-61. https://doi.org/10.1128/CMR.8.4.451 PMid:8665464 PMCid:PMC172870

40. Wagenlehner FM, Brockmeyer NH, Discher T, Friese K, Wichelhaus TA. The presentation, diagnosis, and treatment of sexually transmitted infections. Deutsches Ärzteblatt International. 2016; 113(1-2):11. https://doi.org/10.3238/arztebl.2016.0011

41. Kissinger PJ, Gaydos CA, Seña AC, Scott McClelland R, Soper D, Secor WE, Legendre D, Workowski KA, Muzny CA. Diagnosis and management of Trichomonas vaginalis: summary of evidence reviewed for the 2021 Centers for Disease Control and Prevention sexually transmitted infections treatment guidelines. Clinical Infectious Diseases. 2022; 74:152-61. https://doi.org/10.1093/cid/ciac030 PMid:35416973 PMCid:PMC9006969

42. Meites E. Trichomoniasis: the "neglected" sexually transmitted disease. Infectious Disease Clinics. 2013; 27(4):755-64. https://doi.org/10.1016/j.idc.2013.06.003 PMid:24275268 PMCid:PMC4677781

43. Lewis FM, Bernstein KT, Aral SO. Vaginal microbiome and its relationship to behavior, sexual health, and sexually transmitted diseases. Obstetrics & Gynecology. 2017; 129(4):643-54. https://doi.org/10.1097/AOG.0000000000001932 PMid:28277350 PMCid:PMC6743080

44. Lewis FM, Bernstein KT, Aral SO. Vaginal microbiome and its relationship to behavior, sexual health, and sexually transmitted diseases. Obstetrics & Gynecology. 2017; 129(4):643-54. https://doi.org/10.1097/AOG.0000000000001932 PMid:28277350 PMCid:PMC6743080

45. Menezes CB, Frasson AP, Tasca T. Trichomoniasis-are we giving the deserved attention to the most common non-viral sexually transmitted disease worldwide?. Microbial cell. 2016; 3(9):404. https://doi.org/10.15698/mic2016.09.526 PMid:28357378 PMCid:PMC5354568

46. Schwebke JR, Burgess D. Trichomoniasis. Clinical microbiology reviews. 2004; 17(4):794-803. https://doi.org/10.1128/CMR.17.4.794-803.2004 PMid:15489349 PMCid:PMC523559

47. Nusbaum MR, Wallace RR, Slatt LM, Kondrad EC. Sexually transmitted infections and increased risk of co-infection with human immunodeficiency virus. Journal of Osteopathic Medicine. 2004; 104(12):527-35.

48. Bouchemal K, Bories C, Loiseau PM. Strategies for prevention and treatment of Trichomonas vaginalis infections. Clinical microbiology reviews. 2017; 30(3):811-25. https://doi.org/10.1128/CMR.00109-16 PMid:28539504 PMCid:PMC5475227

49. Gülmezoglu AM, Garner P. Trichomoniasis treatment in women: a systematic review. Tropical Medicine & International Health. 1998; 3(7):553-8. https://doi.org/10.1046/j.1365-3156.1998.00273.x PMid:9705189

50. Kissinger P. Trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues. BMC infectious diseases. 2015; 15:1-8. https://doi.org/10.1186/s12879-015-1055-0 PMid:26242185 PMCid:PMC4525749

51. Klimas N, Koneru AO, Fletcher MA. Overview of HIV. Psychosomatic medicine. 2008 ;70(5):523-30. https://doi.org/10.1097/PSY.0b013e31817ae69f PMid:18541903

52. Bhatti AB, Usman M, Kandi V. Current scenario of HIV/AIDS, treatment options, and major challenges with compliance to antiretroviral therapy. Cureus. 2016 ;8(3). https://doi.org/10.7759/cureus.515

53. Kapila A, Chaudhary S, Sharma RB, Vashist H, Sisodia SS, Gupta A. A review on: Hiv aids. Indian Journal of Pharmaceutical and Biological Research. 2016 ;4(3):69-73. https://doi.org/10.30750/ijpbr.4.3.9

54. Cihlar T, Fordyce M. Current status and prospects of HIV treatment. Current opinion in virology. 2016; 18:50-6. https://doi.org/10.1016/j.coviro.2016.03.004 PMid:27023283

55. Simon V, Ho DD, Karim QA. HIV/AIDS epidemiology, pathogenesis, prevention, and treatment. The Lancet. 2006; 368(9534):489-504. https://doi.org/10.1016/S0140-6736(06)69157-5 PMid:16890836

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2025-06-15
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How to Cite

1.
Dhoke PS, Shelke PG, Hatwar PR, Bakal RL. Sexually Transmitted Diseases: An Overview of Common Diseases, Diagnosis and Treatment. J. Drug Delivery Ther. [Internet]. 2025 Jun. 15 [cited 2026 Jan. 22];15(6):229-37. Available from: https://jddtonline.info/index.php/jddt/article/view/7228

How to Cite

1.
Dhoke PS, Shelke PG, Hatwar PR, Bakal RL. Sexually Transmitted Diseases: An Overview of Common Diseases, Diagnosis and Treatment. J. Drug Delivery Ther. [Internet]. 2025 Jun. 15 [cited 2026 Jan. 22];15(6):229-37. Available from: https://jddtonline.info/index.php/jddt/article/view/7228