Evaluation of Renal Function Status in Type II Diabetic Patients at Khartoum State, Sudan
Abstract
Background: Type II Diabetes mellitus is the most common type of DM which constitute about 85-95% of all Diabetes mellitus cases. Diabetic nephropathy is the kidney disease that occurs as a result of diabetes complication. The aim of this study was to evaluate the renal function status in Sudanese type 2 diabetic patients at Khartoum state, Sudan.
Materials and Method: This study was analytical case control hospital-based study conducted at International University of Africa Hospital, Khartoum state, Sudan, during the period from February to May 2022. Type II diabetic patients who attended at International University of Africa Hospital during aforementioned period were included. In addition to that, healthy participants were selected as control group. A total of 2.5 ml of whole blood was collected from each participant and dispensed into heparin anticoagulated containers for Blood urea and serum creatinine measurement. Measurement of blood urea and serum creatinine was done by using Biochemistry analyzer (Myndray-BS200).
Results: When compared some renal function parameters between cases and control group, the results revealed that the mean blood urea, serum creatinine levels and blood glucose (random) concentration of the case group were significantly high when compared with the control group (0.000). In Gender-wise correlation of renal function tests (RFT) in the cases, the results showed that male patients had higher blood urea and serum creatinine levels when compared with female patients.
Conclusion: Our results of the renal function tests examined; showed significant increase in blood urea, serum creatinine and blood sugar when compared with non-diabetic patients, which indicates abnormality in renal function status.
Keywords: Blood urea, creatinine, diabetes, type II diabetes, DM, renal failure, kidney, hyperglycemia, renal function tests, glucose, random blood glucose
Keywords:
Blood urea, creatinine, diabetes, type II diabetes, DM, renal failure, kidney, hyperglycemia, renal function tests, glucose, random blood glucoseDOI
https://doi.org/10.22270/jddt.v12i6-S.5830References
-Mehta RS, Karki P, Sharma SK, Risk factors, associated health problems, reasons for admission and knowledge profile of diabetes patients admitted in BPKIHS, Kathmandu Univ Med J, 2006; 4(1):11-13.
-American Diabetes Association, Diagnosis and classification of diabetes mellitus, Diabetes Care, 2006; 29(1): S43-8. https://doi.org/10.2337/diacare.29.s1.06.s43
- Caramori ML, Fioretto P, Mauer M, Enhancing the predictive value of urinary albumin for diabetic nephropathy. J Am Soc Nephrol, 2006, 17(2):339-52. Doi: 10.1681/ASN.2005101075. https://doi.org/10.1681/ASN.2005101075
- Elfaki ME, Raheem AM, Ahmed ES, Evaluation of Lipid Metabolism among Sudanese Patients with type II Diabetes Mellitus, Int. J. Pure Appl. Sci. Technol, 2014; 23(1):28-33.
- Adeghate E, Schattner P, Dunn E, An Update on the Etiology and Epidemiology of Diabetes Mellitus, Ann N Y Acad Sci, 2006, 1084:1-29. https://doi.org/10.1196/annals.1372.029
- Whaley-Connell A, Sowers JR, McCullough PA, Roberts T, McFarlane SI, Chen SC, Diabetes mellitus and CKD awareness: the Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES), Am J Kidney Dis, 2009; 53 (4):S11-21. https://doi.org/10.1053/j.ajkd.2009.01.004
-Saran R, Robinson B, Abbott KC, et al, US Renal Data System 2019 Annual Data Report: epidemiology of kidney disease in the United States, Am J Kidney Dis, 2020; 75(1) (suppl 1): Svi-Svii. https://doi.org/10.1053/j.ajkd.2019.09.002
- Vargatu I, Williams Textbook Of Endocrinology. Acta Endocrinol (Buchar). 2016 Jan-Mar; 12(1):113. Doi: 10.4183/aeb.2016.113. PMCID: PMC6586758. https://doi.org/10.4183/aeb.2016.113
- Zimmet P, Alberti KG, Shaw J, Global and societal implications of the diabetes. Natured, 2001; 414:782-787. https://doi.org/10.1038/414782a
- Bamanikar SA, Bamanikar, Arora A, Study of Serum urea and Creatinine in Diabetic and nondiabetic patients in in a tertiary teaching hospital, The Journal AA of Medical Research 2016; 2(1):12-15. https://doi.org/10.31254/jmr.2016.2104
- Amartey N.A.A. , Nsiah K, Mensah F.O., Plasma Levels of Uric Acid, Urea and Creatinine in Diabetics Who Visit the Clinical Analysis Laboratory (Can-Lab) at Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, Journal of Clinical and Diagnostic Research. 2015; 9(2):BC05-BC09. https://doi.org/10.7860/JCDR/2015/10905.5530
- Mishra K.P, Mawar A, Kare PK, Verma N, Relationship between fasting blood glucose, serum urea, serum creatinine and duration of diabetes in type-2 diabetic patients, Flora and Fauna, 2015; 21(1):7-132.
- Sirivole MR, Eturi S, A study on blood urea and serum creatinine in diabetes mellitus from Sangareddy District, Telangana, India, International Journal of Medical and Health Research, 2017; 3(12):132-136.
- Chutani A, Pande S, Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study, Natl J Physiol Pharm Pharmacal, 2017; 7(9): 914-919. https://doi.org/10.5455/njppp.2017.7.0515606052017
- Idonije BO, Festus O, Oluba OM, Plasma Glucose, Creatinine and Urea Levels in Type 2 Diabetic Patients Attending A Nigerian Teaching Hospital, Research Journal of Medical Sciences, 2011; 5 (1):1- 3. https://doi.org/10.3923/rjmsci.2011.1.3
Published
Abstract Display: 978 
PDF Downloads: 718 PDF Downloads: 120 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.