Measurement of Plasma Fibrinogen and D-dimer Levels in Sudanese Hypertensive Patients at Khartoum state

  • Mohamed Hassan Osman Ebar Faculty of Medical Laboratory Science, National University, Sudan
  • Ahmed Gafer Ahmed Ali Faculty of Medical Laboratory Science, National University, Sudan
  • Mohamed Qaje Adan University of Medical Sciences and Technology
  • Albara Ahmed Faculty of Medical Laboratory Science, National University, Sudan
  • Mohamed Osman Mohamed Isse Alzaiem Alazhari University

Abstract

Background: Hypertension is a chronic elevation of blood pressure that, in the long-term, causes end organ damage and results in increased morbidity and mortality. Thrombosis often appears to complicate the course of patients with hypertension; thrombosis in some patients with hypertension could be developed to organ damage. The aim of this study was to measure fibrinogen and D-dimer level among sudanese patients with hypertension.


Materials and method: This was a case control study conducted at Khartoum state, Sudan during the period from May 2022 to August 2022 to measure fibrinogen and D-dimer levels in sudanese patients with hypertension. Blood samples were collected, 50 from the patients as case group, and 50 from normal healthy subjects as control group. A total of three ml of whole blood were collected from each participant in sodium citrated tube. The fibrinogen and D-dimer level measurement was done by using coagulometer (M1 coatron) and ichroma II device respectively.


Results: The results of this study revealed that when compared Fibrinogen level and D-dimer between cases and control group; the results revealed that fibrinogen level was significant increase in hypertensive patients with P-value of 0.000. Also, D-dimer was significant increase in hypertensive patients when compared with the results of control group, and showed significant association with P-value of 0.000. There was a negative correlation between hypertension and the gender, but the age showed positive correlation with hypertension and with D-dimer, where both fibrinogen and D-dimer showed positive correlation with the duration of hypertension.


Conclusion: This study concluded; when compared the fibrinogen level and D- dimer between cases and control group, there was significant increase in fibrinogen and D- dimer.


Keywords: Hypertension, fibrinogen level, D-dimer, coronary artery disease, ischemic heart disease, Cardiovascular disease, DIC, fibrin degradation products

Keywords: Hypertension, fibrinogen level, D-dimer, coronary artery disease, ischemic heart disease, Cardiovascular disease, DIC, fibrin degradation products

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Author Biographies

Mohamed Hassan Osman Ebar, Faculty of Medical Laboratory Science, National University, Sudan

Faculty of Medical Laboratory Science, National University, Sudan

Ahmed Gafer Ahmed Ali, Faculty of Medical Laboratory Science, National University, Sudan

Faculty of Medical Laboratory Science, National University, Sudan

Mohamed Qaje Adan, University of Medical Sciences and Technology

University of Medical Sciences and Technology

Albara Ahmed, Faculty of Medical Laboratory Science, National University, Sudan

Alfajri College, Sudan

Mohamed Osman Mohamed Isse, Alzaiem Alazhari University

Alzaiem Alazhari University, Sudan

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Ebar MHO, Ali AGA, Adan MQ, Ahmed A, Isse MOM. Measurement of Plasma Fibrinogen and D-dimer Levels in Sudanese Hypertensive Patients at Khartoum state. JDDT [Internet]. 15Nov.2022 [cited 9Dec.2022];12(6):48-1. Available from: https://jddtonline.info/index.php/jddt/article/view/5791