Formulation and Evaluation of Pluronic -Lecithin Organogel Containing Natural Moisturizing Agent for Xerosis

Authors

  • Rashmi Trivedi Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India
  • Shraddha Samrit Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India
  • Yogesh Amgaokar Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India
  • Urvashi Supe Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India
  • Milind Umekar Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India
  • Kamlesh Wadher Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Abstract

Xerosis is a common skin condition as well as a key aspect of a number of diseases associated to hereditary and acquired conditions. The objective of this study was to formulate and evaluate the pluronic lecithin organogel containing natural moisturizing agents for topical application.  Different formulations of pluronic lecithin organogels were prepared by using Pluronic F127, Lecithin, Vitamin E, Aloe vera, water, sorbic acid, and potassium sorbate. The gel containing different quantities of Polaxomer, soya lecithin and polyvinyl alcohol were characterized for their mechanical properties and moisturizing capabilities.The pH of the formulations was 6.89- 7.19 reflecting no risk of skin irritation. Pluronic enhances the stability of organogel by increasing the viscosity. The polymeric films, which were produced, were thin, flexible, resistant, and suitable for application on limbs and feet. Studies showed that the film was intact for longer period of time. The results obtained showed that the polymeric films formed from organogel containing vitamin E and Aloe vera could be an innovative therapeutic approach for enhancing the moisturization of skin.

Keywords: Organogel, film forming gel, dry skin, Aloe vera, Vitamin E, soya lecithin, Pluronic F127

Keywords:

Organogel, film forming gel, dry skin, Aloe vera, Vitamin E, soya lecithin, Pluronic F127

DOI

https://doi.org/10.22270/jddt.v12i5.5614

Author Biographies

Rashmi Trivedi, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Shraddha Samrit, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Yogesh Amgaokar, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Urvashi Supe, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Milind Umekar, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Kamlesh Wadher, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India

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Published

15-09-2022
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How to Cite

1.
Trivedi R, Samrit S, Amgaokar Y, Supe U, Umekar M, Wadher K. Formulation and Evaluation of Pluronic -Lecithin Organogel Containing Natural Moisturizing Agent for Xerosis. J. Drug Delivery Ther. [Internet]. 2022 Sep. 15 [cited 2025 Feb. 13];12(5):170-4. Available from: https://jddtonline.info/index.php/jddt/article/view/5614

How to Cite

1.
Trivedi R, Samrit S, Amgaokar Y, Supe U, Umekar M, Wadher K. Formulation and Evaluation of Pluronic -Lecithin Organogel Containing Natural Moisturizing Agent for Xerosis. J. Drug Delivery Ther. [Internet]. 2022 Sep. 15 [cited 2025 Feb. 13];12(5):170-4. Available from: https://jddtonline.info/index.php/jddt/article/view/5614

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