Preparation and Characterization of Artemether Solid Dispersion by Spray Drying Technique
Abstract
Introduction: Artemether, a BCS class IV drug (poorly water soluble and poorly permeable, less bioavailability) but is found to be effective against falciparum malaria. Preparation of water soluble formulation could be the technique to improve bioavailability of such drug. The most ideally used technique to enhance the solubility and dissolution of poorly water soluble drugs is Solid dispersion method.
Method: The objective of the study was to enhance the solubility and dissolution rate of Artemether by preparing solid dispersions using Soluplus, at different ration of 1:1, 1:2, 1:3 and 1:4 using spray drying technology. Prepared Solid dispersions were characterized by Fourier transform infrared spectroscopy and differential scanning calorimetry.
Results: The spray-dried solid dispersions found to be having less crystallinity and showed higher dissolution rates. Solubility study data showed the optimum drug/Soluplus ratio to be 1:3. The dissolution studies of Solid dispersions in 1.2 pH and 6.8 pH buffer showed higher drug release as compared to pure drug.
Conclusion: Thus we conclude that an amorphous solid dispersion of Artemether could be a better option for enhancing the dissolution rate of drug
Keywords: solid dispersion, artemether, soluplus, solubility enhancement
Keywords:
solid dispersion, artemether, soluplus, solubility enhancementDOI
https://doi.org/10.22270/jddt.v11i2.4557References
Biamonte MA, Wanner J, Le Roch KG. Recent advances in malaria drug discovery. Bioorganic Med Chem Lett. 2013; 23(10):2829-2843.
Konno H, Taylor LS. Influence of Different Polymers on the Crystallization Tendency of Molecularly Dispersed Amorphous Felodipine. J Pharm Sci. 2006; 95(12):2692-2705.
Patil S, Suryavanshi S, Pathak S, Sharma S, Patravale V. Evaluation of novel lipid based formulation of β-Artemether and Lumefantrine in murine malaria model. Int J Pharm. 2013; 455(1-2):229-234.
Pawar JN, Shete RT, Gangurde AB, et al. Development of amorphous dispersions of artemether with hydrophilic polymers via spray drying: Physicochemical and in silico studies. Asian J Pharm Sci. 2016; 11:385-395.
Vo CL-N, Park C, Lee B-J. Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs. Eur J Pharm Biopharm. 2013; 85(3):799-813.
Wadher KJ, Bagde A, Ailwar S, Umekar MJ. Formulation and evaluation of sustained release gastroretentive dosage form of Metformin HCl. Der Pharm Lett. 2013; 5(2):264-271.
S. Prodduturi, R. V. Manek, W. M. Kolling, S. P. Stodghill, and M. A. Repka, “Solid-state stability and characterization of hotmelt extruded poly(ethylene oxide) films,” Journal of Pharmaceutical Sciences, 2005; 94(10):2232–2245.
Repka MA, Prodduturi S, Stodghill SP. Production and Characterization of Hot-Melt Extruded Films Containing Clotrimazole,2003; 29(7):757-65.
Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today. 2007; 12(23-24):1068-1075.
Janssens S, Van den Mooter G. Review: physical chemistry of solid dispersions. J Pharm Pharmacol. 2009; 61(12):1571-1586.
The united state pharmacopeial SALMOUS guidelines 2009
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