A Comprehensive Review on Biological Activity of Green Tea (Camellia sinensis)

Authors

  • Ruksar Mansoori Truba Institute of Pharmacy, Karond Bypass Rd, Gandhi Nagar, Bhopal, MP-462038
  • Deepti Jain School of Pharmaceutical Science, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Rd, Abbas Nagar, Gandhi Nagar, Bhopal, MP- 462033
  • Varsha Pandey School of Pharmaceutical Science, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Rd, Abbas Nagar, Gandhi Nagar, Bhopal, MP- 462033
  • Surendra Kumar Jain Truba Institute of Pharmacy, Karond Bypass Rd, Gandhi Nagar, Bhopal, MP-462038

Abstract

Green tea, the commonly consumed beverage, is gaining increased attention in promoting overall health. In specific, green tea is considered a healthful beverage due to the biological activity of its polyphenols namely catechins. The main green tea polyphenols are catechins: (±)-catechin C, (-)-epicatechin EC, (+)-gallocatechin GC, (-)-epigallocatechin EGC, (-)-epicatechin gallate ECG, and (-)-epigallocatechin gallate EGCG. Among the polyphenols Epigallocatechin 3 gallate and Epicatechin 3 Gallate are the most predominant catechins. There are also human studies on using green tea catechins to treat chronic diseases such as obesity, type II diabetes, and cardiovascular risk factors. Long-term consumption of tea catechins could be beneficial against high-fat diet-induced obesity and type II diabetes and could reduce the risk of coronary disease. Several epidemiological studies have proved that green tea also has some general health benefitting properties like anti-obesitive agent, anti-oxidant, anti-aging, anti-diabetic, anti-hyperlipidemic, anti-hypertension, anti-cancer, anti-bacterial, anti-viral, anti-inflammatory, anti-parkinson's effects, anti-alzheimer's effects, anti-arthritic, anticollagenase, and antimutagenic etc. The properties of these catechins proved to be helpful in the treatment of chronic diseases like obesity, aging, diabetes, cardiovascular disease, hyperlipidemic, hypertension, cancer, microbial, parkinson's, alzheimer's, arthritis, and periodontal disease. There are numerous studies in humans, animal models, and cell lines which provide the concepts for underlying functional mechanisms of green tea catechins and their biological actions and to suggest potential health benefits from the consumption of tea, including prevention of cancer and heart diseases. The review highlights also the potentials of green tea, its health benefits in terms of their properties. The present review concentrates on the effects of green tea on different chronic disease and general health.

Keywords: Green tea, Polyphenols, Epidemiological, Catechins, Animal models

Keywords:

Green tea, Polyphenols, Epidemiological, Catechins, Animal models

DOI

https://doi.org/10.22270/jddt.v12i5.5613

Author Biographies

Ruksar Mansoori, Truba Institute of Pharmacy, Karond Bypass Rd, Gandhi Nagar, Bhopal, MP-462038

Truba Institute of Pharmacy, Karond Bypass Rd, Gandhi Nagar, Bhopal, MP-462038

Deepti Jain, School of Pharmaceutical Science, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Rd, Abbas Nagar, Gandhi Nagar, Bhopal, MP- 462033

School of Pharmaceutical Science, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Rd, Abbas Nagar, Gandhi Nagar, Bhopal, MP- 462033

Varsha Pandey, School of Pharmaceutical Science, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Rd, Abbas Nagar, Gandhi Nagar, Bhopal, MP- 462033

School of Pharmaceutical Science, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Rd, Abbas Nagar, Gandhi Nagar, Bhopal, MP- 462033

Surendra Kumar Jain, Truba Institute of Pharmacy, Karond Bypass Rd, Gandhi Nagar, Bhopal, MP-462038

Truba Institute of Pharmacy, Karond Bypass Rd, Gandhi Nagar, Bhopal, MP-462038

References

Graham H. Green tea composition, consumption and polyphenol chemistry. Preventive Medicine. 1992; 21(3):334-350. https://doi.org/10.1016/0091-7435(92)90041-F

Sang S, Lambert J, Ho C, Yang C. The chemistry and biotransformation of tea constituents. Pharmacological Research. 2011; 64(2):87-99. https://doi.org/10.1016/j.phrs.2011.02.007

Pooja B, Deepa K. Green tea catechins: defensive role in cardiovascular disorders. Chinese Journal of Natural Medicines 2014: 11(4):345-353. https://doi.org/10.3724/SP.J.1009.2013.00345

Diepvens K, Kovacs E, Vogels N, Westerterpplantenga M. Metabolic effects of green tea and of phases of weight loss. Physiology & Behavior. 2006; 87(1):185-191. https://doi.org/10.1016/j.physbeh.2005.09.013

Sharangi A. Medicinal and therapeutic potentialities of tea (Camellia sinensis L.) - A review. Food Research International.2009; 42(5-6):529-535 https://doi.org/10.1016/j.foodres.2009.01.007

Yun CH, Kim GR, Seo MJ, Moon HS, Cho CS. McKinley H, Jamieson M, and editors, Anti-obesity effects of (-)-epigallocathchin 3-gallate and its molecular mechanism. Handbook of Green Tea and Health Research. 2009.

Rahman K. Studies on free radicals, antioxidants and co-factors. Clin Interv Aging. 2007; 2:219-36.

Aslani A, Ghannadi A, Najafi H. Design, formulation and evaluation of a mucoadhesive gel from Quercus brantii L. and coriandrum sativum L. as periodontal drug delivery. Advanced Biomedical Research.2013; 2(1):21. https://doi.org/10.4103/2277-9175.108007

Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y, Shimamura T. Inhibition of the infectivity of influenza virus by tea polyphenols. Antiviral Research.1993; 21(4):289-299. https://doi.org/10.1016/0166-3542(93)90008-7

Yamaguchi K, Honda M, Ikigai H, Hara Y, Shimamura T. Inhibitory effects of (−)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1). Antiviral Research.2002; 53(1):19-34. https://doi.org/10.1016/S0166-3542(01)00189-9

Guo S, Yan J, Yang T, Yang X, Bezard E, Zhao B. Protective effects of green tea polyphenols in the 6-ohda rat model of parkinson's disease through inhibition of ros-no pathway. Biological Psychiatry.2007; 62(12): 1353-1362. https://doi.org/10.1016/j.biopsych.2007.04.020

Okello E, Savelev S, Perry E. In vitro anti-?-secretase and dual anti-cholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia. Phytotherapy Research.2004; 18(8):624-627. https://doi.org/10.1002/ptr.1519

Belitz DH, Grosch W. Food chemistry, 4th revised and extended edition, 2009.

Sano M, Tabata M. Suzuki M, Degawa M, Miyase T, Maeda-Yamamoto M. Simultaneous determination of twelve tea catechins by high-performance liquid chromatography with electrochemical detection. The Analyst.2001; 126(6):816-820. https://doi.org/10.1039/b102541b

McKay D, Blumberg J. The Role of Tea in Human Health: An Update. Journal of the American College of Nutrition.2002; 21(1):1-13. https://doi.org/10.1080/07315724.2002.10719187

Reto M, Figueira M, Filipe H, Almeida C. Chemical composition of green tea (camellia sinensis) infusions commercialized in portugal. Plant Foods for Human Nutrition. 2007; 62(4):139-144. https://doi.org/10.1007/s11130-007-0054-8

Liao S, Kao Y, Hiipakka RA. Green tea: biochemical and biological basis for health benefits. Vitamins and Hormones. 2001; 62:4-5. https://doi.org/10.1016/S0083-6729(01)62001-6

Chung E, Campise S, Joiner H, Tomison M, Kaur G, Dufour J. Effect of annatto-extracted tocotrienols and green tea polyphenols on glucose homeostasis and skeletal muscle metabolism in obese male mice. The Journal of Nutritional Biochemistry.2019; 67:36-43. https://doi.org/10.1016/j.jnutbio.2019.01.021

Naderi Nabi B, Sedighinejad A, Haghighi M, Farzi F, Rimaz S, Atrkarroushan Z, Biazar G. The anti-obesity effects of green tea: a controlled, randomized, clinical trial. Iranian Red Crescent Medical Journal.2018; 20(1):23-28. https://doi.org/10.5812/ircmj.55950

Henning S, Yang J, Hsu M, Lee R, Grojean E, Ly A, Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice. European Journal of Nutrition.2017; 57(8): 2759-2769. https://doi.org/10.1007/s00394-017-1542-8

Seo D, Jeong H, Cho D, Lee B, Lee J, Choi J, Bae I, Lee S. Fermented green tea extract alleviates obesity and related complications and alters gut microbiota composition in diet-induced obese mice. Journal of Medicinal Food.2015; 18(5): 549-556. https://doi.org/10.1089/jmf.2014.3265

Zhang Y, Yu Y, Li X, Meguro S, Hayashi S, Katashima M. Effects of catechin-enriched green tea beverage on visceral fat loss in adults with a high proportion of visceral fat: A double-blind, placebo-controlled, randomized trial. Journal of Functional Foods.2012; 4(1):315-322. https://doi.org/10.1016/j.jff.2011.12.010

Suliburska J, Bogdanski P, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients. Biological Trace Element Research.2012; 149(3):315-322. https://doi.org/10.1007/s12011-012-9448-z

Brown A, Lane J, Holyoak C, Nicol B, Mayes A, Dadd T. Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial. British Journal of Nutrition.2011; 106(12):1880-1889. https://doi.org/10.1017/S0007114511002376

Sadowska-Krępa E, Domaszewski P, Pokora I, Żebrowska A, Gdańska A, Podgórski T. Effects of medium-term green tea extract supplementation combined with CrossFit workout on blood antioxidant status and serum brain-derived neurotrophic factor in young men: a pilot study. Journal of the International Society of Sports Nutrition.2019; 16(1):56-59. https://doi.org/10.1186/s12970-019-0280-0

Rahimi R, Falahi Z. Effect of green tea extract on exercise-induced oxidative stress in obese men: a randomized, double-blind, placebo-controlled, crossover study. Asian Journal of Sports Medicine.2017. https://doi.org/10.5812/asjsm.55438

Wang S, Huang Y, Xu H, Zhu Q, Lu H, Zhang M. Oxidized tea polyphenols prevent lipid accumulation in liver and visceral white adipose tissue in rats. European Journal of Nutrition. 2016; 56(6):2037-2048. https://doi.org/10.1007/s00394-016-1241-x

Sundaram R, Naresh R, Shanthi P, Sachdanandam P. Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats. Phytomedicine.2013; 20(7):577-584. https://doi.org/10.1016/j.phymed.2013.01.006

Roghani M, Baluchnejadmojarad T. Hypoglycemic and hypolipidemic effect and antioxidant activity of chronic epigallocatechin-gallate in streptozotocin-diabetic rats. Pathophysiology. 2010; 17(1): 55-59. https://doi.org/10.1016/j.pathophys.2009.07.004

Tsuneki H, Ishizuka M, Terasawa M, Wu J, Sasaoka T, Kimura I. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC Pharmacology.2004; 4(1):18. https://doi.org/10.1186/1471-2210-4-18

Kuttan R. Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. Journal of Ethnopharmacology. 2002; 83(1-2):109-116. https://doi.org/10.1016/S0378-8741(02)00217-9

Amanolahi F, Rakhshande H. Effects of ethanolic extract of green tea on decreasing the level of lipid profile in rat, Avicenna J Phytomed. 2013; 3(1):98-105.

Hsu C, Tsai T, Kao Y, Hwang K, Tseng T, Chou P. Effect of green tea extract on obese women: A randomized, double-blind, placebo-controlled clinical trial. Clinical Nutrition. 2008; 27(3):363-370. https://doi.org/10.1016/j.clnu.2008.03.007

Nagao T, Hase T, Tokimitsu I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity.2007; 15(6):1473-1483. https://doi.org/10.1038/oby.2007.176

Negishi H, Xu J, Ikeda K, Njelekela M, Nara Y, Yamori Y. Black and Green Tea Polyphenols Attenuate Blood Pressure Increases in Stroke-Prone Spontaneously Hypertensive Rats. The Journal of Nutrition.2004; 134(1):38-42. https://doi.org/10.1093/jn/134.1.38

Maron D, Lu G, Cai N, Wu Z, Li Y, Chen H. Cholesterol-lowering effect of a theaflavin-enriched green tea extract. Archives of Internal Medicine.2003; 163(12):1448. https://doi.org/10.1001/archinte.163.12.1448

Manikandan R, Beulaja M, Arulvasu C, Sellamuthu S, Dinesh D, Prabhu D. Synergistic anticancer activity of curcumin and catechin: An in vitro study using human cancer cell lines. Microscopy Research and Technique.2011; 75(2):112-116. https://doi.org/10.1002/jemt.21032

Xu C, Shu W, Qiu Z, Chen J, Zhao Q, Cao J. Protective effects of green tea polyphenols against subacute hepatotoxicity induced by microcystin-LR in mice. Environmental Toxicology and Pharmacology. 2007; 24(2):140-148. https://doi.org/10.1016/j.etap.2007.04.004

Nishikawa T, Nakajima T, Moriguchi M, Jo M, Sekoguchi S, Ishii M, Takashima H. A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins. Journal of Hepatology. 2006; 44(6):1074-1082. https://doi.org/10.1016/j.jhep.2005.11.045

Parvez M, Saha K, Rahman J, Munmun R, Rahman M, Dey S, Rahman M. Antibacterial activities of green tea crude extracts and synergistic effects of epigallocatechingallate (EGCG) with gentamicin against MDR pathogens. Heliyon. 2019; 5(7):02126. https://doi.org/10.1016/j.heliyon.2019.e02126

Araghizadeh A, Kohanteb J, Fani M. Inhibitory activity of green tea(camellia sinensis)extract on some clinically isolated cariogenic and periodontopathic bacteria. Medical Principles and Practice.2013; 22(4):368-372. https://doi.org/10.1159/000348299

Li S, Hattori T, Kodama E. Epigallocatechin gallate inhibits the hiv reverse transcription step. Antiviral Chemistry and Chemotherapy.2011; 21(6):239-243. https://doi.org/10.3851/IMP1774

Song J, Lee K, Seong B. Antiviral effect of catechins in green tea on influenza virus. Antiviral Research. 2005; 68(2):66-74. https://doi.org/10.1016/j.antiviral.2005.06.010

Oz H, Chen T, Flomenhoft D, De Villiers W. Tu1644 green tea polyphenols and sulfasalazine have parallel anti-inflammatory properties in colitis models. Gastroenterology.2013; 144(5): S-813. https://doi.org/10.1016/S0016-5085(13)63013-9

Chattopadhyay C, Ghosh D, Bhattacharyay D, Chakrabarti N, Chatterjee M, Chatterjee S. Evaluation of acute anti-inflammatory and analgesic activities of green tea decoction on experimental animal models. International Journal of Nutrition, Pharmacology, Neurological Diseases.2012; 2(1): 20. https://doi.org/10.4103/2231-0738.93128

Oz H, Chen T. Green-tea polyphenols downregulate cyclooxygenase and bcl-2 activity in acetaminophen-induced hepatotoxicity. Digestive Diseases and Sciences.2008; 53(11):2980-2988. https://doi.org/10.1007/s10620-008-0239-5

Metz N, Lobstein A, Schneider Y, Gosse F, Schleiffer R, Anton R, Raul F. Suppression of azoxymethane-induced preneoplastic lesions and inhibition of cyclooxygenase-2 activity in the colonic mucosa of rats drinking a crude green tea extract. Nutrition and Cancer.2000; 38(1):60-64. https://doi.org/10.1207/S15327914NC381_9

Bitu Pinto N, Da Silva Alexandre B, Neves K, Silva A, Leal L, Viana G. Neuroprotective properties of the standardized extract fromcamellia sinensis(green tea) and its main bioactive components, epicatechin and epigallocatechin gallate, in the 6-ohda model of parkinson's disease. Evidence-Based Complementary and Alternative Medicine. 2015; 1-12. https://doi.org/10.1155/2015/161092

Biasibetti R, Tramontina A, Costa A, Dutra M, Quincozes-Santos A, Nardin P. Green tea (−)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia. Behavioural Brain Research.2013; 236:186-193. https://doi.org/10.1016/j.bbr.2012.08.039

Zhu W, Shi H, Wei Y, Wang S, Sun C, Ding Z, Lu L. Green tea polyphenols produce antidepressant-like effects in adult mice. Pharmacological Research.2012; 65(1):74-80. https://doi.org/10.1016/j.phrs.2011.09.007

Kaur T, Pathak C, Pandhi P, Khanduja K. Effects of green tea extract on learning, memory, behavior and acetylcholinesterase activity in young and old male rats. Brain and Cognition. 2008; 67(1):25-30. https://doi.org/10.1016/j.bandc.2007.10.003

Zheng Y, Xiao L, Yu C, Jin P, Qin D, Xu Y. Enhanced antiarthritic efficacy by nanoparticles of (−)-epigallocatechin gallate-glucosamine-casein. Journal of Agricultural and Food Chemistry.2019; 67(23):6476-6486. https://doi.org/10.1021/acs.jafc.9b02075

Leong D, Choudhury M, Hanstein R, Hirsh D, Kim S, Majeska R. Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative. Pharmacological Research.2014; 34-45. https://doi.org/10.1186/s13075-014-0508-y

Liu D, Li P, Song S, Liu Y, Wang Q, Chang Y. Pro-apoptotic effect of Epigallo-catechin-3-gallate on B lymphocytes through regulating BAFF/PI3K/Akt/mTOR signaling in rats with collagen-induced arthritis. European Journal of Pharmacology.2012; 690(1-3):214-225. https://doi.org/10.1016/j.ejphar.2012.06.026

Kim H, Rajaiah R, Wu Q, Satpute S, Tan M, Simon J, Berman B, Moudgil K. Green tea protects rats against autoimmune arthritis by modulating disease-related immune events. The Journal of Nutrition.2008; 138(11): 2111-2116 https://doi.org/10.3945/jn.108.089912

Haqqi T, Anthony D, Gupta S, Ahmad N, Lee M, Kumar G. Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proceedings of the National Academy of Sciences.1999; 96(8):4524-4529. https://doi.org/10.1073/pnas.96.8.4524

Liu J, Lu Y, Liu J, Jin C, Meng Y, Pei D. Influence of epigallocatechin-3-gallate in promoting proliferation and osteogenic differentiation of human periodontal ligament cells. BMC Oral Health.2019; 19(1):110-118. https://doi.org/10.1186/s12903-019-0768-7

Ramachandra S, Sharma S, Bhuyan L, Sharma S, Dash K, Dhull K. Effects of green tea on periodontal health: A prospective clinical study. Journal of International Oral Health.2017; 9(2):39. https://doi.org/10.4103/jioh.jioh_37_17

Nakamura H, Ukai T, Yoshimura A, Kozuka Y, Yoshioka H, Yoshinaga Y. Green tea catechin inhibits lipopolysaccharide-induced bone resorptionin vivo. Journal of Periodontal Research.2010; 45(1):23-30. https://doi.org/10.1111/j.1600-0765.2008.01198.x

Lodhia P, Yaegaki K, Khakbaznejad A. Effect of Green Tea on Volatile Sulfur Compounds in Mouth Air. Journal of Nutritional Science and Vitaminology.2008; 54(1):89-94. https://doi.org/10.3177/jnsv.54.89

Yun J, Pang E, Kim C, Yoo Y, Cho K, Chai J, Kim C. Inhibitory effects of green tea polyphenol (-)-epigallocatechin gallate on the expression of matrix metalloproteinase-9 and on the formation of osteoclasts. Journal of Periodontal Research.2004; 39(5):300-307. https://doi.org/10.1111/j.1600-0765.2004.00743.x

Sakanaka S, Aizawa M, Kim M, Yamamoto T. Inhibitory effects of green tea polyphenols on growth and cellular adherence of an oral bacterium,porphyromonas gingivalis. Bioscience, Biotechnology, and Biochemistry.1996; 60(5):745-749. https://doi.org/10.1271/bbb.60.745

Published

20-09-2022
Statistics
Abstract Display: 893
PDF Downloads: 512
PDF Downloads: 74

How to Cite

1.
Mansoori R, Jain D, Pandey V, Jain SK. A Comprehensive Review on Biological Activity of Green Tea (Camellia sinensis). J. Drug Delivery Ther. [Internet]. 2022 Sep. 20 [cited 2025 Mar. 24];12(5):250-65. Available from: https://jddtonline.info/index.php/jddt/article/view/5613

How to Cite

1.
Mansoori R, Jain D, Pandey V, Jain SK. A Comprehensive Review on Biological Activity of Green Tea (Camellia sinensis). J. Drug Delivery Ther. [Internet]. 2022 Sep. 20 [cited 2025 Mar. 24];12(5):250-65. Available from: https://jddtonline.info/index.php/jddt/article/view/5613

Most read articles by the same author(s)