Methylcobalamine (Vitamin B12): Water Soluble Vitamin with Various Pharmacological Aspect

  • Roopesh Kumar Yadav School of Pharmaceutical Science, Rajiv Gandhi Prodyogiki Viswavidyalaya, Bhopal, India
  • Sudhanshu Mishra School of Pharmaceutical Science, Rajiv Gandhi Prodyogiki Viswavidyalaya, Bhopal, India
  • Deepti Jain School of Pharmaceutical Science, Rajiv Gandhi Prodyogiki Viswavidyalaya, Bhopal, India

Abstract

Vitamin B12 is a water-soluble vitamin that plays a key role in the brain's proper functioning and nervous system, in blood flow, and in reducing weakness and tiredness. In their food, most people get adequate vitamin B12, but in some health conditions (e.g. inadequate sleep, stomach/intestinal disorders, inflammation, cancer), there could be a shortage. If left unchecked, severe Vitamin B12 deficiency results in anemia and nerve damage. Vitamin B12 deficiency is typically treated using parenteral and oral dosage formulations, but absorption and compliance problems are involved with these routes of administration. Most significantly, the function of this missing intrinsic factor has been shown to assist in vitamin B12 absorption and a deficiency known as pernicious anaemia. Vitamin B12 is only partially absorbed when delivered by mouth to patients with pernicious anemia, but hematologically re-absorbed in patients with pernicious anemia. Parenteral administration of the extrinsic element will treat pernicious anaemia satisfactorily. There are several roles and advantages of vitamin B 12 in the human body with therapeutic effects also.


Keywords: Water Soluble Vitamins, Methylcobalamine, Vitamin B12, Pernicious Anaemia.

Keywords: Water Soluble Vitamins, Methylcobalamine, Vitamin B12, Pernicious Anaemia

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Author Biographies

Roopesh Kumar Yadav, School of Pharmaceutical Science, Rajiv Gandhi Prodyogiki Viswavidyalaya, Bhopal, India

School of Pharmaceutical Science, Rajiv Gandhi Prodyogiki Viswavidyalaya, Bhopal, India

Sudhanshu Mishra, School of Pharmaceutical Science, Rajiv Gandhi Prodyogiki Viswavidyalaya, Bhopal, India

School of Pharmaceutical Science, Rajiv Gandhi Prodyogiki Viswavidyalaya, Bhopal, India

Deepti Jain, School of Pharmaceutical Science, Rajiv Gandhi Prodyogiki Viswavidyalaya, Bhopal, India

School of Pharmaceutical Science, Rajiv Gandhi Prodyogiki Viswavidyalaya, Bhopal, India

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Yadav RK, Mishra S, Jain D. Methylcobalamine (Vitamin B12): Water Soluble Vitamin with Various Pharmacological Aspect. JDDT [Internet]. 15Jan.2021 [cited 22Sep.2021];11(1):130-7. Available from: https://jddtonline.info/index.php/jddt/article/view/4488