Formulation and Characterization of Novel Transfersomes Gel for Enhance TDDS of Losartan Potassium
Abstract
A transferosome is the first generation of an elastic liposome prepared from phospholipids and edge activators. An edge activator is often a single-chain surfactant with a high radius of curvature that destabilizes the lipid bilayers of vesicles and increases the deformability of the bilayers, thereby making the vehicle ultra-deformable. Losartan potassium is an orally active angiotensin-II receptor antagonist used in the treatment of hypertension due to mainly blockade of AT1 receptor. It is freely soluble in water, slightly soluble in acetonitrile, and soluble in isopropyl alcohol. The aim of the present study was to investigate the potential of transfersomal gel formulations for transdermal delivery of losartan potassium by reverse phase evaporation method. Characterization of transfersomes gel performed by vesicle size, pH measurements, drug content, entrapment efficiency, in vitro drug diffusion study, spreadability and stability study. In the formulations pH is found to be around 6.8 to 6.9, pH is found in the range of 6 which is compatible with skin. In the formulations spreadability is found to be around 6.75 to 10.11 g m cm/sec. The prepared gel containing losartan potassium-loaded transfersomal formulation was optimized and can be use for topical preparation. The results were obtained which showed that transfersomal gel was a promising candidate for transdermal delivery with targeted and prolonged release of a drug. It also enhances skin permeation of many drugs.
Keywords: Transferosome gel, Losartan potassium, Antihypertensives, Reverse phase evaporation method
Keywords:
Transferosome gel, Losartan potassium, Antihypertensives, Reverse phase evaporation methodDOI
https://doi.org/10.22270/jddt.v12i4-S.5525References
Komiyama M, Yoshimoto K, Sisido M, Ariga K. Chemistry can make strict and fuzzy controls for bio-systems: DNA nanoarchitectonics and cell-macromolecular nanoarchitectonics. Bull Chem Soc Jpn., 2017; 90(9):967-1004. https://doi.org/10.1246/bcsj.20170156
Kim CJ, Kurauchi S, Uebayashi T, Fujisaki A, Kimura S. Morphology change from nanotube to vesicle and monolayer/bilayer alteration by amphiphilic block polypeptides having aromatic groups at C terminal. Bull Chem Soc Jpn., 2017; 90(5):568-573. https://doi.org/10.1246/bcsj.20170044
NVS M, Saini A. Niosomes: A novel drug delivery system. Int J Res Pharm Chem., 2011; 1(3):498-511. https://doi.org/10.4103/2231-0738.77539
Muzzalupo R, Tavano L, Cassano R, Trombino S, Ferrarelli T, Picci N. A new approach for the evaluation of niosomes as effective transdermal drug delivery systems. Eur J Pharm Biopharm., 2011; 79(1):28-35. https://doi.org/10.1016/j.ejpb.2011.01.020
Gallego-Perez D, Pal D, Ghatak S, Malkoc V, Higuita-Castro N, Gnyawali S, et al., Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue. Nat Nanotechnol., 2017; 12(10):974. https://doi.org/10.1038/nnano.2017.134
Mir-Palomo S, Nácher A, Díez-Sales O, Busó M, Caddeo C, Manca M, et al., Inhibition of skin inflammation by baicalin ultradeformable vesicles. Int J Pharm., 2016; 511:23-29. https://doi.org/10.1016/j.ijpharm.2016.06.136
Aljaeid B, Hosny K. Miconazole-loaded solid lipid nanoparticles: formulation and evaluation of a novel formula with high bioavailability and antifungal activity. Int J Nanomed., 2016; 11:441-447. https://doi.org/10.2147/IJN.S100625
Sean CS. The Complete Drug Reference, 34th Edition, London, England, UK: Pharmaceutical Press; 2011
Malakar J, Sen SO, Nayak AK, Sen KK. Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery. Saudi Pharma J., 2012; 20(4):355-363. https://doi.org/10.1016/j.jsps.2012.02.001
Published
Abstract Display: 520 
PDF Downloads: 439 PDF Downloads: 127 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.