Intelligent or Smart Polymers: Advance in Novel Drug Delivery

Authors

  • Arpana Purohit Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Sameeksha Jain Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Prakhar Nema Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Harshna Vishwakarma Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Prateek Kumar Jain Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Abstract

Novel drug delivery system utilizing smart polymer to get significant and attracting changes in the targeting of drugs, increasing the bioavailability of drugs, enhancement patient compliance  and gene therapy. The scientific community tries to mimic nature in the way that living organisms adopt their behavior as a function of environmental conditions to improve survival. In this sense, smart polymers offer materials that respond to numerous stimuli (temperature, pH, electric and magnetic fields, light intensity, biological molecules, etc.), and scientists must devise the best way to apply them in all research areas. Smart polymers are representing promising means for targeted drug delivery, enhanced drug delivery, gene therapy, actuator stimuli and protein folders. Smart polymers are very promising applicants in drug delivery, tissue engineering, cell culture, gene carriers, textile engineering, oil recovery, radioactive wastage and protein purification. The study is focused on the entire features of smart polymers and their most recent and relevant applications.

Keywords: Smart polymer, Novel drug delivery system, Stimuli, Gene therapy

Keywords:

Smart polymer, Novel drug delivery system, Stimuli, Gene therapy

DOI

https://doi.org/10.22270/jddt.v12i5.5578

Author Biographies

Arpana Purohit, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Sameeksha Jain, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Prakhar Nema, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Harshna Vishwakarma, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Prateek Kumar Jain, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

References

Davis SS, Illum L. Long circulating microparticulate drug carriers. Int J Pharm, 1998; 176:1-8.

Jeong B, Gutowska A. Lessons from nature: stimuli responsive polymers and their biomedical applications. Trends Biotechnol, 2002; 20:305-11. https://doi.org/10.1016/S0167-7799(02)01962-5

Hoffman AS, Stayton PS, Bulmus V, Chen G, Jinping C, Chueng C, et al. Really smart bioconjugates of smart polymers and receptor proteins. J Biomed Mater Res, 2000; 52:577-86. https://doi.org/10.1002/1097-4636(20001215)52:4<577::AID-JBM1>3.0.CO;2-5

Galaev IYu, Mattiasson B. 'Smart' polymers and what they could do in biotechnology and medicine. Trends Biotechnol, 2000; 17:335-40. https://doi.org/10.1016/S0167-7799(99)01345-1

Kikuchi A, Okano T. Intelligent thermoresponsive polymeric stationary phases for aqueous chromatography of biological compounds. Prog Polym Sci, 2002; 27:1165-93. https://doi.org/10.1016/S0079-6700(02)00013-8

Qiu Y, Park K. Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev, 2001; 53:321-39. https://doi.org/10.1016/S0169-409X(01)00203-4

Okano T. Molecular design of temperature-responsive polymers as intelligent materials. In: Dusek K, editor. Responsive gels: volume transitions, vol. II. Berlin: Springer; 1993. pp. 180-97.

Twaites BR, Alarcon CH, Cunliffe D, Lavigne M, Pennadam S, Smith JR, et al. Thermo and pH responsive polymers as gene delivery vectors: effect of polymer architecture on DNA complexation in vitro. J Control Release, 2004; 97:551-66. https://doi.org/10.1016/S0168-3659(04)00154-3

Lomadze N, Schneider H-J. Ternary complex formation inducing large expansions of chemomechanical polymers by metal chelators, aminoacids and peptides as effectors. Tetrahedron Lett, 2005; 46:751-4. https://doi.org/10.1016/j.tetlet.2004.12.032

Kabanov VA. Physicochemical basis and the prospects of using soluble interpolyelectrolyte complex. Polym Sci, 1994; 36:143-56.

Leclercq L, Boustta M, Vert M. A physico-chemical approach of polyanion-polycation interactions aimed at better understanding the in vivo behaviour of polyelectrolyte- based drug delivery and gene transfection. J Drug Target, 2003; 11:129-38. https://doi.org/10.1080/1061186031000150287

Filipcsei G, Feher J, Zrinyi M. Electric field sensitive neutral polymer gels. J Mol Struct, 2000; 554:109-17. https://doi.org/10.1016/S0022-2860(00)00564-0

Zrinyi M. Intelligent polymer gels controlled by magnetic fields. Colloid Polym Sci, 2000; 278:98-103. https://doi.org/10.1007/s003960050017

Juodkazis S, Mukai N, Wakaki R, Yamaguchi A, Matsuo S, Misawa H. Reversible phase transitions in polymer gels induced by radiation forces. Nature, 2000; 408:178-81. https://doi.org/10.1038/35041522

Galaev IYu, Gupta MN, Mattiasson B. Use smart polymers for bioseparations. Chemtech, 1996; 26:19-25.

Taylor LD, Gerankowski LD. Preparation of films exhibiting balanced temperature dependence to permeation by aqueous solutions-a study of lower consolute behavior. J Polymer Sci Polymer Chem Ed, 1975; 13:2551-70. https://doi.org/10.1002/pol.1975.170131113

Galaev IY, Mattiason B. Smart polymers and what they do in biotechnology and medicine. Trends Biotechnol, 1999; 17:335-340. https://doi.org/10.1016/S0167-7799(99)01345-1

Hoffmann AS, Stayton PS. Bioconjugates of smart polymers and proteins: synthesis and application. Pharmaceut Sci J, 2004; 207: 139-151. https://doi.org/10.1002/masy.200450314

Athawale VD, Lele VL. Recent trends in hy-drogels based on starchgraft-acrylic acid: a review. Starch/Starke, 2001; 53(1):7-13. https://doi.org/10.1002/1521-379X(200101)53:1<7::AID-STAR7>3.0.CO;2-Q

Mohtaram NK, Montgomery A, Willerth SM. Biomaterial-based drug delivery systems for the controlled release of neurotrophic factors.Biomed. Mater, 2013; 89: 022001. https://doi.org/10.1088/1748-6041/8/2/022001

Al-Tahami K, Singh J. Smart polymer based delivery systems for peptides and proteins. Recent Pat Drug Deliv Formul, 2007; 1:65-71. https://doi.org/10.2174/187221107779814113

Roy I, Gupta MN. Smart Polymeric Materials: Emerging Biochemical Applications. Chem Biol, 2003; 10:1161-1171. https://doi.org/10.1016/j.chembiol.2003.12.004

Chan A, Orme RP, Fricker RA, Roach P. Remote and local control of stimuli responsive materials for therapeutic applications. Adv Drug Deliv Rev, 2013; 65:497-514. https://doi.org/10.1016/j.addr.2012.07.007

Foss AC, Goto T, Morishita M, Peppas NA. Development of acrylicbasedcopolymers for oral insulin delivery. Eur J Pharm Biopharm, 2004; 57:163-9. https://doi.org/10.1016/S0939-6411(03)00145-0

Peng CL, Yang LY, Luo TY, Lai PS, Yang SJ, Lin WJ, et al. Development of pH sensitive 2-(disopropylamino)ethyl methacrylate based nanoparticles for photodynamic therapy. Nanotechnol, 2010; 21:155013. https://doi.org/10.1088/0957-4484/21/15/155103

Gohy JF, Lohmeijer BGG, Varshney SK, Decamps B, Leroy E, Boileau S, et al. Stimuli-responsive aqueous micelles from an ABC metallosupramolecular triblock copolymer. Macromolecules, 2002; 35:9748-55. https://doi.org/10.1021/ma021175r

Zhao LL, Zhu L, Liu FY, Liu CY, Shan-Dan, Wang Q, et al. pH triggered injectable amphiphilic hydrogel containing doxorubicin and paclitaxel. Int J Pharm, 2011; 410:83-91. https://doi.org/10.1016/j.ijpharm.2011.03.034

Garbern JC, Minami E, Stayton PS, Murry C. Delivery of basic fibroblast growth factor with a pH-responsive, injectable hydrogel to improve angiogenesis in infarcted myocardium. Biomaterials, 2011; 32:2407-16. https://doi.org/10.1016/j.biomaterials.2010.11.075

Kulkarni RV, Boppana R, Krishna MG, Mutalik S, Kalyane NV. pHresponsive interpenetrating network hydrogel beads of poly(acrylamide)- g-carrageenan and sodium alginate for intestinal targeted drug delivery: synthesis, in vitro and in vivo evaluation. J Colloid Interface Sci, 2012; 367:509-17. https://doi.org/10.1016/j.jcis.2011.10.025

Wang K, Xu X, Wang Y, Yan X, Guo G, Huang M, et al. Synthesis and characterization of poly(methoxyl ethylene glycol-caprolactoneco- methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate) pH-sensitive hydrogel for delivery of dexamethasone. Int J Pharm, 2010; 389:130-8. https://doi.org/10.1016/j.ijpharm.2010.01.026

El-Sherbiny IM. Enhanced pH-responsive carrier system based on alginate and chemically modified carboxymethyl chitosan for oral delivery of protein drugs: preparation and in-vitro assessment. Carbohyd Polym, 2010; 80:1125-36. https://doi.org/10.1016/j.carbpol.2010.01.034

Singh S, Webster DC, Singh J. Thermosensitive polymers: synthesis, characterization, and delivery of proteins. Int J Pharm, 2007; 341: 68-77. https://doi.org/10.1016/j.ijpharm.2007.03.054

Jeong B, Kim SW, Bae WH. Thermosensitive sol-gel reversible hydrogels. Adv Drug Deliv Rev, 2002; 54:37-51. https://doi.org/10.1016/S0169-409X(01)00242-3

Qiu Y, Park K. Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev, 2001; 53:321-39. https://doi.org/10.1016/S0169-409X(01)00203-4

Aguilar MR, Elvira C, Gallardo A, Vázquez B, Román JS. Smart polymers and their applications as biomaterials. In: Ashammakhi N, Reis R, Chiellini E, editors. Topics in tissue engineering. Vol. 6. Pennsylvania: CiteSeer; 2007, pp. 1-27.

Choi S, Baudys M, Kim SW. Control of blood glucose by novel GLP- 1 delivery using biodegradable triblock copolymer of PLGA-PEG- PLGA in type 2 diabetic rats. Pharm Res, 2004; 21:827-31. https://doi.org/10.1023/B:PHAM.0000026435.27086.94

Ruel-Gariépy E, Leroux JC. In situ-forming hydrogels-review of temperature-sensitive systems. Eur J Pharm Biopharm, 2004; 58:409-26. https://doi.org/10.1016/j.ejpb.2004.03.019

Schmaljohann D. Thermo-and pH-responsive polymers in drug delivery. Adv Drug Deliv Rev, 2006; 58:1655-70. https://doi.org/10.1016/j.addr.2006.09.020

Bae WK, Park MS, Lee JH, Hwang JE, Shim HJ, Cho SH, et al. Docetaxel-loaded thermoresponsive conjugated linoleic acidincorporated poloxamer hydrogel for the suppression of peritoneal metastasis of gastric cancer. Biomaterials, 2013; 34:2834-42. https://doi.org/10.1016/j.biomaterials.2012.10.077

Li K, Yu L, Liu XJ, Chen C, Chen Q, Ding J. A long-acting formulation of a polypeptide drug exenatide in treatment of diabetes using an injectable block copolymer hydrogel. Biomaterials, 2013; 34: 2834-42. https://doi.org/10.1016/j.biomaterials.2013.01.013

Hsiao MH, Larsson M, Larsson A, Evenbratt H, Chen YY, Chen YY, et al. Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide. J Control Release, 2012; 161:942-8. https://doi.org/10.1016/j.jconrel.2012.05.038

Conn LH, Helena MK, Mary JM, Frank PB, Fergal JO, et al. Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia. J Control Release, 2012; 161:73-80. https://doi.org/10.1016/j.jconrel.2012.04.033

Licciardi M, Amato G, Cappelli A, Paolino M, Giuliani G, Belmonte B, et al. Evaluation of thermoresponsive properties and biocompatibility of polybenzofulvene aggregates for leuprolide delivery. Int J Pharm, 2012; 438:279-86. https://doi.org/10.1016/j.ijpharm.2012.09.023

Ravaine V, Ancla C, Catargi B. Chemically controlled closed-loop insulin delivery. J Control Release, 2008; 132:2-11. https://doi.org/10.1016/j.jconrel.2008.08.009

Roy VD, Cambre JN, Sumerlin BS. Future perspectives and recent advances in stimuli-responsive materials. Prog Polym Sci, 2010; 35: 278-301. https://doi.org/10.1016/j.progpolymsci.2009.10.008

Takemoto Y, Ajiro H, Asoh TA, Akashi M. Fabrication of surfacemodified. Hydrogels with polyion complex for controlled release. Chem Mater, 2010; 22:2923-9. https://doi.org/10.1021/cm1002302

Yin RX, Tong Z, Yang DZ, Nie J. Glucose-responsive insulin delivery microhydrogels from methacrylated dextran/concanavalin A: preparation and in vitro release study. Carbohyd Polym, 2012; 89:117-23. https://doi.org/10.1016/j.carbpol.2012.02.059

Yin R, Tong Z, Yang D, Nie J. Glucose and pH dual-responsive concanavalin A based microhydrogels for insulin delivery. Int J Biol Macromol, 2011; 49:1137-42. https://doi.org/10.1016/j.ijbiomac.2011.09.014

Fleige E, Quadir MA, Haag R. Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications. Adv Drug Deliv Rev, 2012; 64:866-84. https://doi.org/10.1016/j.addr.2012.01.020

Kang SI, Bae YH. A sulfonamide based glucose-responsive hydrogel with covalently immobilized glucose oxidase and catalase. J Control Release, 2003; 86:115-21. https://doi.org/10.1016/S0168-3659(02)00409-1

You J, Shao RP, Wei X, Gupta S, Li A. Near-infrared light triggers release of paclitaxel from biodegradable microspheres: Photothermal effect and enhanced antitumor activity. Small, 2010; 6:1022-31. https://doi.org/10.1002/smll.201000028

Lee SY, Tae G. Formulation and in vitro characterization of an in situ gelable, photo-polymerizable Pluronic hydrogel suitable for injection. J Control Release, 2007; 119:313-9. https://doi.org/10.1016/j.jconrel.2007.03.007

Goodwin AP, Mynar JL, Ma YZ, Fleming GR, Fréchet JMJ. Synthetic micelle sensitive to IR light via a two-photon process. J Am Chem Soc, 2005; 127:9952-3. https://doi.org/10.1021/ja0523035

Murdan S. Electro-responsive drug delivery from hydrogels. J Control Release, 2003; 92:1-17. https://doi.org/10.1016/S0168-3659(03)00303-1

Tanaka IN, Nishio I, Sun ST, Ueno NS. Collapse of gels in an electric field. Science, 1982; 218:467-9. https://doi.org/10.1126/science.218.4571.467

Gong JP, Nitta T, Osada Y. Electrokinetic modeling of the contractile phenomena of polyelectrolyte gels. One-dimensional capillary model. J Phys Chem, 1994; 98:9583-7. https://doi.org/10.1021/j100089a036

Kwon IC, Bae YH, Okano T, Kim SW. Drug release from electric current sensitive polymers. J Control Release, 1991; 17:149-56. https://doi.org/10.1016/0168-3659(91)90054-H

Zhao X, Kim J, Cezar CA, Huebsch N, Lee K, Bouhadir K, et al. Active scaffolds for on-demand drug and cell delivery. Proc Natl Acad Sci USA, 2011; 108:67-72. https://doi.org/10.1073/pnas.1007862108

Gil ES, Hudson SM. Stimuli-responsive polymers and their bioconjugates. Prog Polym Sci, 2004; 29:1173-1222. https://doi.org/10.1016/j.progpolymsci.2004.08.003

Lou L, Kato M, Tsuruta T, Kataoka K, Nagasaki Y. Stimuli-sensitive polymer gels that stiffen upon swelling. Macromolecules J, 2000; 33: 4992-4994. https://doi.org/10.1021/ma000388i

Gonalez N, Elvira C, San Roman J. Novel dualstimuli- responsive polymers derived from ethylpyrrolidine. Macromolecules J, 2005; 38: 9298-9303. https://doi.org/10.1021/ma050939a

Huang J, Wu. XY. Effects of pH, salt, surfactant and composition on phase transition of poly (NIPAm/ MAA) nanoparticles. Polym Sci J, 1999; 37: 2667- 2676. https://doi.org/10.1002/(SICI)1099-0518(19990715)37:14<2667::AID-POLA42>3.0.CO;2-J

Kokufuta E, Zhang YQ, Tanaka T, Mamada A. Effects of surfectants on the phase-transition of polymer (N-iso-propylacrylamide) gel. Macromolecules J, 1993; 26: 1053-1059. https://doi.org/10.1021/ma00057a027

Higuchi T. Mechanism of sustained-action mechanism. Pharm Sci J, 1963; 52: 1145-1149. https://doi.org/10.1002/jps.2600521210

Singh S, Singh J. Controlled release of a model protein lyzozyme from phase sensitive smart polymer systems. Intl J Pharma, 2004; 271:189- 196. https://doi.org/10.1016/j.ijpharm.2003.11.010

Published

15-09-2022
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How to Cite

1.
Purohit A, Jain S, Nema P, Vishwakarma H, Jain PK. Intelligent or Smart Polymers: Advance in Novel Drug Delivery. J. Drug Delivery Ther. [Internet]. 2022 Sep. 15 [cited 2025 Feb. 14];12(5):208-16. Available from: https://jddtonline.info/index.php/jddt/article/view/5578

How to Cite

1.
Purohit A, Jain S, Nema P, Vishwakarma H, Jain PK. Intelligent or Smart Polymers: Advance in Novel Drug Delivery. J. Drug Delivery Ther. [Internet]. 2022 Sep. 15 [cited 2025 Feb. 14];12(5):208-16. Available from: https://jddtonline.info/index.php/jddt/article/view/5578

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