A promising cognition boosting effect of leaves of Abrus precatorius
Objective: To assess the leaves of Abrus precatorius had earlier show cognition boosting effect against dementia in rodents. Methods: The methanol extract was fractionated into ethyl acetate and aqueous fractions and assessed for its nootropic and learning activity in albino rodents. The effect of triterpenoids containing ethylacetate soluble fraction of methanol extract significant enhancement in the retention ability of amnesic mice as compared to their respective controls using elevated plus maze and Cook and Weidley’s pole apparatus. Subsequently, the extracts were further studied for its in vitro acetylcholinesterase (AChE) inhibitory potential which can correlate with an improvement in cholinergic transmission. Piracetam was used as the standard drug while scopolamine hydrobromide served as the amnestic agent. Result: A.precatorius ethylacetate (APEA) soluble fraction of leaves produced a significant acquisition, retention and retrieval at dosed 150 and 300 mg/kg in interoceptive as well as exteroceptive memory models of rodents. While A.precatorius aqueous fraction (APAqs) of methanol extract not enhances both the acquisition as well as the retention of memory of learned task when administered at a dose of 300 mg/kg for a period of 7 days. It was found that APEA fraction potentially inhibits AChE with percentage inhibition of 91.33±0.33. Furthermore, both fraction were found safe with no deaths in mice treated orally with 2000 mg/kg.
Conclusion: APEA showed to be a useful memory restorative agent in the treatment of dementia from the experiments performed.
Keywords: Abrus precatorius, Piracetam, Scopolamine, Dementia
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