Evaluation of Drug Release from Carboxymethyl Starch-Xanthan Gum-HPMC Matrix
The use of hydrophilic polymers from natural origin. Especially the polysaccharides have been the focus of current research activity in the design of matrix device due to their non toxic, biocompatible, biodegradable nature and broad regulatory acceptance. A large number of polysaccharides such as Carboxymethyl starch, Xanthan gum, Hydroxy propyl methyl cellulose (HPMC), Sodium Alginate etc, have been used as hydrophilic matrices to investigate release behavior of drug. In order to enrich the resources, there is a quest for new polysaccharide owing to their diverse chemical composition and functional groups are amenable to chemical modification and thus tailor made polymeric matrices are obtained which which can be used to modulate oral drug release. The objective of the study is to characterize Verapamil hydrochloride loaded matrix dosage form using hydroxy propyl methyl cellulose (HPMC), xanthan gum, corn starch as rate retarding polymer. Dosage forms were prepared using different polymers along with drug Verapamil hydrochloride. Carboxymethylation was performed. Drug release was evaluated in simulated gastric media. Addition of xanthan gum significantly retarded the burse release of drug. The retardation of drug release was found to be dependent upon the concentration. The formulation composed of HPMC K4M and CS (ARI-ARI3) followed super case transport is swelling controlled, purely relaxation controlled drug delivery.
Keywords: Verapamil HCl, Natural gums, xanthan gum, HPMC, sustained release
2. Robinson J.R, Lee VHL., Controlled Drug Delivery, Fundamentals and Applications, 2nded., New York, Marcel Dekker, 1978, [373-380].
3. Obaidat AA, Obaidat RM. Controlled release of tramadol hydrochloride from matrices prepared using glyceryl behenate. Eur J Pharm Biopharm. 2001; 52:231Y235. https://doi.org/10.1016/S0939-6411(01)00173-4
4. Malonne H, Fontaine J, Moes A. In vitro/in vivo characterization of a tramadol HCl depot system composed of monoolein and water. Biol Pharm Bull. 2000; 23:627Y631. https://doi.org/10.1248/bpb.23.627
5. Zhang ZY, Ping QN, Xiao B. Microencapsulation and characterization of tramadol-resin complexes. J Control Release.m2000; 66:107Y113. https://doi.org/10.1016/S0168-3659(99)00273-4
6. Krishnaiah YSR, Karthikeyan RS, Satyanarayana V. A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate. Int J Pharm. 2002; 241:353Y366. https://doi.org/10.1016/S0378-5173(02)00273-9
7. Kumar R, Patil MB, Patil SR, Paschapur MS. Polysaccharides based colon specific drug delivery: A review. Int. J Pharm Tech Res 2009; 1(2): 334-346.
8. Tonnesen HH, Karlsen J. Alginate in drug delivery system. Drug Deliv. Indus Pharm 2008; 28(6):621-630. https://doi.org/10.1081/DDC-120003853
9. Miyazaki S, Kubo W, Attwood DJ. Oral sustained delivery of Theophyline using in-situ gelation of sodium alginate. Journal of Controlled Release 2000; 67(2-3):275-280. https://doi.org/10.1016/S0168-3659(00)00214-5
10. Bhardwaj TR, Kanwar M, Lal R, Gupta A. Natural Gums and modified natural gums as sustained release carriers. Drug Deliv Indus Pharm 2000; 26:1025-1038. https://doi.org/10.1081/DDC-100100266
11. Sultzbaugh KJ, Speaker TJJ.A method to attach lectins to the surface of spermine alginate microparticles based on the avidin biotin interaction. J of Microencaps 1996; 13(4):363-375. https://doi.org/10.3109/02652049609026023
12. Quong D,Neufeld RJ.DNA encapsulation within co-guanidine membrane coated alginate beads and protection from extracapsular nuclease. J of Microencaps 1999; 16(5):573-585. https://doi.org/10.1080/026520499288771
13. Halder A, Mukherjee S, Sa B. Development and evaluation of polyethyleneimine-treated calcium alginate beads for sustained release of Diltiazem. J. Microencap 2005; 22:67-80. https://doi.org/10.1080/02652040500045003
14. Almeida PF, Almeida AJ. Cross linked alginate-gelatin beads: a new matrix for controlled release of pindolol. J of Control Release 2004; 97:431-439. https://doi.org/10.1016/j.jconrel.2004.03.015
15. Lu MF, Woodward L, Borodkin S. Xanthan gum and alginate based controlled release theophyllin formulations. Drug Dev Ind Pharm. 1991; 17:1987Y2004. https://doi.org/10.3109/03639049109048063
16. Costa P, Manuel J. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001; 13:123Y133. https://doi.org/10.1016/S0928-0987(01)00095-1
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