Gastro-protective effects of methanol extract of Tephrosia calophylla
Abstract
Objective: The present research work was designed to investigate gastro protective potentials of methanol extract of Tephrosia calophylla.
Methods: The aerial parts of Tephrosia calophylla were dried under shade, powdered and deffated with petroleum ether and then marc left over was subjected to methanol extraction using soxhlet apparatus. Antiulcer activity of methanol extract was determined against stress induced and aspirin induced ulcers in experimental animal models. The total number of ulcers formed, ulcer index, percentage inhibition, ulcerated area, protected area, pH and Total acidity were parameters in the study.
Results: Methanol extract of Tephrosia calophylla have significantly reduced the total number of ulcers formed, ulcer index, ulcerated area and total acidity in therapeutic groups compare to vehicle control and there by significantly increased percentage inhibition of ulcers and protected area which was evident by significant rise in pH of gastric content. The effect of extracts was dose dependent and results were comparable to that of standard drug omeprazole.
Conclusion: The results obtained from the present work suggest that the methanol extract of Tephrosia calophylla possess significant anti-ulcer potentials against experimentally induced ulcers in albino rats.
Keywords: Tephrosia calophylla, Anti ulcer activity, Ethanol, Aspirin Ulcer index, pH, total acidity, Percentage inhibition and percentage of protected area.
DOI
https://doi.org/10.22270/jddt.v8i6-s.2100References
Hussain L, Akash MS, Naseem S, et al. Anti-Ulcerogenic effects of Salmalia malabarica in gastric ulceration – Pilot Study. Adv Clin Exp Med 2015; 24:595–605.
Malfertheiner P, Chan FK, McColl KE. Peptic ulcer disease. Lancet 2009; 374:1449-1461.
Scanlon VC and Sanders T. Essential of Anatomy and Physiology, 5th Edn., F. A. Davis company, Philadelphia, 2007, 396.
Toma W, Hiruma-Lima CA, Guerrero RO, Souza Brito AR. Preliminary studies of Mammea Americana L (Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer models in mice. Phytomedicine 2005; 12:345-50.
Al-Yahya MA, Rafatullah S, Mossa JS, Ageel AM, Al-Said MS, Tariq M. Gastric antisecretory, antiulcer and cytoprotective properties of ethanol extract of Alpinia galanga willd in rats. Phytotherapy Research 1990; 4:112-4.
Santin JR, Lemos M, Júnior LCK, Niero R, de Andrade SF. Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models. Journal of Ethnopharmacology. 2010; 130(2):334–6.
Saldanha CJ, Singh BG, Leguminosae, In: Saldanha C.J. (Ed.) Flora of Karnataka Vol:I, Oxford and IBH, 1984, 495-499.
Sarin jagat PS, Singh S, Garg H, Khanna NM, Dhar MM, A flavonol glycoside with anticancer activity from Tephrosia candida, Phytochemistry, 1976, 15(1):232-234.
Chen Yuh-Lin, New piscicidal flavonoids from Tephrosia obovata merr, Asian. J. Pharm., 1978; 3(4):18.
Bentley MD, Hassanali A, Lwande W, Njoroge PEW, Yatagai M, Insect anti feed ants from Tephrosia elata Deflers, Insect. Sci. Appl., 1987; 8(1):85-88.
Gokhale AB, Saraf MN, Tephrosia purpurea, A review of contemporary literature and medicinal properties, Indian Drugs, 2000; 37:12.
Kapoor SL, Kapoor LD. Medicinal Plant Wealth of the Karimnagar District of Andhra Pradesh. Bull Med Ethnobotanical Res 1980; 1:120-44.
Jain SR, Sharma SN: Hypoglycaemic Drugs of Indian Indigenous Origin. Planta Medica 1967; 15(4):439-42.
Ramadhani SON, Zakaria HM, Abdul WK, Ester MI, Matobola JM, Paul E and Mainen JM. Larvicidal,antimicrobial and brine shrimp activities of extracts from Cissampelos mucronata and Tephrosia villosa from coast region, Tanzania. BMC Comp & Alt Med; 2011; 11:33.
Kokate CK. Practical Pharmacognosy. New Delhi, Vallabh Prakashan 1994; 4:110-1.
Kokate CK. Practical Pharmacognosy. New Delhi; Vallabh Prakashan: 1994; 4:110-1.
Khandelwal KR, Practical Pharmacognosy-Techniques and Experiments. Pune; NiraliPrakashan; 2000. Trease GE., Evans MC. Text book of Pharmacognosy London, BailliareTindall; 1983; 12:193,336.
OECD, 2000. Acute Oral Toxicity-Acute Oral Toxic Class Method. Guideline 423, adopted 23.03.1996. In: Eleventh Addendum to the OECD Guidelines for the Testing of Chemicals. Organisation for Economic Co-operation and Development, Paris.
Vogel H. Drug Discovery and Evaluation Pharmacological Assays.2nd Edition 2002. New York: Springer-Verlag Berlin Heidelberg : 870-75.
Aitken J, Fisher H. Reactive oxygen species generation and human spermatozoa. The balance of benefit and risk. Bioassays 1994; 16:259-67.
Agrawal R, Garg HK, Garg U, S mgh Sk. Antiulcer activity of Smithia Conferta in various animal. J sand chem., Soc, 2010; 14:307-10.
Shreedhara CS, Aswatha Ram HN, Sachin B, Zanwar. Free radical scavenging activity of aqueous root extract of Argyreia nervosa. J Nat Remedies 2009; 9: 23.
Van JR. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nature 1971; 235:231-235.
Szabo S, Trier JS, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985; 88:228-236.
Konturek SJ, Piastucki, Brzozwski T, Radecki T, Dembinska KA, Zmuda A, Gryglewski R. Role of prostaglandins in the formation of Aspirin induced gastric ulcers. Gastroenterology 1979; 80:4-9.
Schubeer MI. Pharmacotherapy for acid/peptic disorders. Yale J Biol. Med 1996; 69:197-201.
Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S: Antioxidant activity of Bacopa moniera in rat frontal cortex, striatum and hippocampus. Phytother Res 2000; 14:1-6.
Ch. V Rao, Ojha SK, Radhakrishnan K, Govindarajan R, Rastogi S, Mehrotra S, Pushpagandan P. Antiulcer activity of Utleria salcifolia rhizome extract. J Ethannopharmacol 2004; 91:243-9.
Cochran T, Stefanko J, Moore C, Saik R. Dimethyl sulfoxide protection against gastric stress ulceration. Cur Surg 1983; 40: 435-7.
Kunchady E. Oxygen radical scavenging activity of curcumin. Int J Pharmacol 1990; 58:237-40.
Govindarajan R. Studies on antioxidant activities of Desmodium gangaticum Biol Pharm Bull 2003; 26:1424-7.
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