FROM FORMULATION VARIABLES TO DRUG ENTRAPMENT EFFICIENCY OF MICROSPHERES: A TECHNICAL REVIEW

Authors

  • Ram Chand Dhakar Dept of Pharmaceutics, JJT University, Chudela, Jhunjhunu, INDIA
  • Sheo Dutta Maurya Dept. of Pharmacy, IEC Group of Institution, Greater Noida, INDIA
  • Vikrant Saluja Faculty of Pharmaceutical Sciences, PCTE Group of Insitutes, Ludhiana, INDIA

Abstract

Purpose of writing this review on microspheres was to compile the recent literature with special focus on formulation variables which affect the drug entrapment efficiency of microspheres. There are various approaches in delivering a therapeutic substance to the target site in a controlled release fashion. One such approach is using microspheres as carriers for drugs.  Microencapsulation is used to modify and delayed drug release form pharmaceutical dosage forms. For success of microspheres as drug delivery system its necessary to obtained desired particle size, maximum drug entrapment, mucoadhesion, swelling index and drug release. This can be obtained by optimizing the formulation as well as process variables but before designing the microspheres formulation deep understanding the effect of various variables on characteristics of microspheres is necessary. The intent of the paper is to highlight the reported study on various formulation variables those are might be useful to encountered several problems which is reason for low drug entrapment efficiency

DOI

https://doi.org/10.22270/jddt.v2i6.160

Author Biographies

Ram Chand Dhakar, Dept of Pharmaceutics, JJT University, Chudela, Jhunjhunu, INDIA

Dept of Pharmaceutics, JJT University, Chudela, Jhunjhunu, INDIA

Sheo Dutta Maurya, Dept. of Pharmacy, IEC Group of Institution, Greater Noida, INDIA

Dept. of Pharmacy, IEC Group of Institution, Greater Noida, INDIA

Vikrant Saluja, Faculty of Pharmaceutical Sciences, PCTE Group of Insitutes, Ludhiana, INDIA

Faculty of Pharmaceutical Sciences, PCTE Group of Insitutes, Ludhiana, INDIA

Published

11-11-2012
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How to Cite

1.
Dhakar RC, Maurya SD, Saluja V. FROM FORMULATION VARIABLES TO DRUG ENTRAPMENT EFFICIENCY OF MICROSPHERES: A TECHNICAL REVIEW. J. Drug Delivery Ther. [Internet]. 2012 Nov. 11 [cited 2025 Mar. 18];2(6). Available from: https://jddtonline.info/index.php/jddt/article/view/160

Issue

Vol. 2 No. 6 (2012): Volume 2, Issue 6, Nov-Dec 2012

Section

Review

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How to Cite

1.
Dhakar RC, Maurya SD, Saluja V. FROM FORMULATION VARIABLES TO DRUG ENTRAPMENT EFFICIENCY OF MICROSPHERES: A TECHNICAL REVIEW. J. Drug Delivery Ther. [Internet]. 2012 Nov. 11 [cited 2025 Mar. 18];2(6). Available from: https://jddtonline.info/index.php/jddt/article/view/160
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