Phytochemical Screening, GCMS and FTIR Profile of Bioactive Compounds in Solanum lycopersicum Wild Fruits collected from Palani Hill Ranges of the Western Ghats
Tomatoes are consumed worldwide as fresh vegetables because of their high contents of essential nutrients and antioxidant-rich phytochemicals. Tomatoes contain minerals, vitamins, proteins, essential amino acids (Leucine, Threonine, Valine, Histidine, Lysine, Arginine), monounsaturated fatty acids (Linoleic and Linolenic Acids), Carotenoids (Lycopene and β-Carotenoids) and Phytosterols (β-Sitosterol, Campesterol and Stigmasterol). GCMS analysis revealed the presence of 3-methylheptane, Ethylcyclohexane, 2-Methyl-4,6-octadiyn-3-one, 5,6-Dimethylundecane, (3E)3-Hexen-2-one, 2,2-Dimethylbutane, 1,2-Diphenyl-1-butanone, Isopropylbenzene (2-phenylpropane), 3,5-Dimethyloctane, 2-Phenyl-3-buten-1-ol, 2,4,4-Trimethylhexane, Benzoylcarboxaldehyde (Phenylglyoxal), Cis-3-Methyl-Endo-Tricyclo [22.214.171.124(2.6)] Decane, 2,4-Dimethylhexan-3-One, Benzene acetic acid,2-phenylethyl ester, Cyclopentacycloheptene, 2,3-Heptanedione, 1,6-Methano annulene, 1-Naphthaleneacetic acid, methyl ester, N,N-Dimethylmethanesulfonamide, Methyl tridecanoate, Cis 9-Octadecanoic acid, Methyl 15-methylheptadecanoate, 9-Octadecenoic acid, Methyl (Z)-octadec-9-enoate, (Z)-octadec-9-enamide, Methyl 2-ethyl-2-methylicosanoate, 1,2,3,4,4a,5,6,7,8,9,10,11,12,12a-tetradecahydrobenzo  annulene Caffeic acid, Catechin, Chlorogenic acid, Chrysin, Cinnamic acid, Epicatechin, Ferulic acid, Kaempferol, Luteolin, Lycopene, Naringenin, P-coumaric acid, Phloretic acid, Quercetin, Resveratrol, Rutin, Sinapic acid, Vanillic acid. Lycopene, the main dietary carotenoid in tomato and tomato-based food products and lycopene consumption by humans has been reported to protect against Cancer, Cardiovascular Diseases, Cognitive function and Osteoporosis. Among phenolic compounds present in tomato, Quercetin, Kaempferol, Naringenin, Caffeic Acid and Lutein are the most common. These compounds have significant antioxidant properties and are effective in protecting human body against oxidative stress-related diseases.
Keywords: Solanum lycopersicum; Phytochemical Screening; GCMS; FTIR
2. Beecher GR. Nutrient content of tomatoes and tomato products. Proceedings of the Society for Experimental Biology and Medicine. 1998 Jun; 218(2):98-100. https://doi.org/10.3181/00379727-218-44282a
3. Ali MY, Sina AA, Khandker SS, Neesa L, Tanvir EM, Kabir A, Khalil MI, Gan SH. Nutritional composition and bioactive compounds in tomatoes and their impact on human health and disease: A review. Foods. 2020 Dec 26; 10(1):45. https://doi.org/10.3390/foods10010045
4. Nour V, Panaite TD, Ropota M, Turcu R, Trandafir I, Corbu AR. Nutritional and bioactive compounds in dried tomato processing waste. CyTA-Journal of Food. 2018 Jan 1; 16(1):222-9. https://doi.org/10.1080/19476337.2017.1383514
5. Abushita AA, Hebshi EA, Daood HG, Biacs PA. Determination of antioxidant vitamins in tomatoes. Food Chemistry. 1997 Oct 1; 60(2):207-12. https://doi.org/10.1016/S0308-8146(96)00321-4
6. Abushita AA, Daood HG, Biacs PA. Change in carotenoids and antioxidant vitamins in tomato as a function of varietal and technological factors. Journal of Agricultural and Food Chemistry. 2000 Jun 19; 48(6):2075-81. https://doi.org/10.1021/jf990715p
7. Vélez-Terreros PY, Romero-Estévez D, Yánez-Jácome GS, Simbaña-Farinango K, Navarrete H. Comparison of major nutrients and minerals between organic and conventional tomatoes. A review. Journal of Food Composition and Analysis. 2021 Jul 1; 100:103922. https://doi.org/10.1016/j.jfca.2021.103922
8. Brodowski D, Geisman JR. Protein content and amino acid composition of protein of seeds from tomatoes at various stages of ripeness. Journal of Food Science. 1980 Mar; 45(2):228-9. https://doi.org/10.1111/j.1365-2621.1980.tb02582.x
9. Collins EJ, Bowyer C, Tsouza A, Chopra M. Tomatoes: an extensive review of the associated health impacts of tomatoes and factors that can affect their cultivation. Biology. 2022 Feb 4; 11(2):239. https://doi.org/10.3390/biology11020239
10. Cámara M, Fernández-Ruiz V, Sánchez-Mata MC, Cámara RM, Domínguez L, Sesso HD. Scientific Evidence of the Beneficial Effects of Tomato Products on Cardiovascular Disease and Platelet Aggregation. Frontiers in Nutrition. 2022; 9. https://doi.org/10.3389/fnut.2022.849841
11. Przybylska S, Tokarczyk G. Lycopene in the prevention of cardiovascular diseases. International Journal of Molecular Sciences. 2022 Feb 10; 23(4):1957. https://doi.org/10.3390/ijms23041957
12. Wang C, Li M, Duan X, Abu-Izneid T, Rauf A, Khan Z, Mitra S, Emran TB, Aljohani AS, Alhumaydhi FA, Thiruvengadam M. Phytochemical and Nutritional Profiling of Tomatoes; Impact of Processing on Bioavailability-A Comprehensive Review. Food Reviews International. 2022 Jul 15:1-25. https://doi.org/10.1080/87559129.2022.2097692
13. Jaglan P, Buttar HS, Al-bawareed OA, Chibisov S. Potential health benefits of selected fruits: Apples, blueberries, grapes, guavas, mangos, pomegranates, and tomatoes. InFunctional Foods and Nutraceuticals in Metabolic and Non-Communicable Diseases 2022 Jan 1 (pp. 359-370). Academic Press. https://doi.org/10.1016/B978-0-12-819815-5.00026-4
14. Hsieh MJ, Huang CY, Kiefer R, Lee SD, Maurya N, Velmurugan BK. Cardiovascular Disease and Possible Ways in Which Lycopene Acts as an Efficient Cardio-Protectant against Different Cardiovascular Risk Factors. Molecules. 2022 Jan; 27(10):3235. https://doi.org/10.3390/molecules27103235
15. Włodarczyk K, Smolińska B, Majak I. Tomato allergy: the characterization of the selected allergens and antioxidants of tomato (solanum lycopersicum)-a review. Antioxidants. 2022 Mar 28; 11(4):644. https://doi.org/10.3390/antiox11040644
16. Kumar M, Tomar M, Bhuyan DJ, Punia S, Grasso S, Sa AG, Carciofi BA, Arrutia F, Changan S, Singh S, Dhumal S. Tomato (Solanum lycopersicum L.) seed: A review on bioactives and biomedical activities. Biomedicine & Pharmacotherapy. 2021 Oct 1; 142:112018. https://doi.org/10.1016/j.biopha.2021.112018
17. Szabo K, Dulf FV, Diaconeasa Z, Vodnar DC. Antimicrobial and antioxidant properties of tomato processing byproducts and their correlation with the biochemical composition. Lwt. 2019 Dec 1; 116:108558. https://doi.org/10.1016/j.lwt.2019.108558
18. Dalbeni A, Treggiari D, Tagetti A, Bevilaqua M, Bonafini S, Montagnana M, Scaturro G, Minuz P, Fava C. Positive effects of tomato paste on vascular function after a fat meal in male healthy subjects. Nutrients. 2018 Sep 15; 10(9):1310. https://doi.org/10.3390/nu10091310
19. Chaudhary P, Sharma A, Singh B, Nagpal AK. Bioactivities of phytochemicals present in tomato. Journal of food science and technology. 2018 Aug; 55(8):2833-49. https://doi.org/10.1007/s13197-018-3221-z
20. Gu M, Fang H, Gao Y, Su T, Niu Y, Yu LL. Characterization of enzymatic modified soluble dietary fiber from tomato peels with high release of lycopene. Food Hydrocolloids. 2020 Feb 1; 99:105321. https://doi.org/10.1016/j.foodhyd.2019.105321
21. Pirozzi A, Ferrari G, Donsì F. Cellulose Isolation from Tomato Pomace Pretreated by High-Pressure Homogenization. Foods. 2022 Jan 19; 11(3):266. https://doi.org/10.3390/foods11030266
22. Akşit Z, Gençcelep H. Investigation of Tomato, Quince and Grapefruit Waste; Compositions and Functional Properties. Hittite Journal of Science and Engineering. 2021; 8(1):19-26. https://doi.org/10.17350/HJSE19030000208
23. Kaboré K, Konaté K, Sanou A, Dakuyo R, Sama H, Santara B, Compaoré EW, Dicko MH. Tomato By-Products, a Source of Nutrients for the Prevention and Reduction of Malnutrition. Nutrients. 2022 Jul 13; 14(14):2871. https://doi.org/10.3390/nu14142871
24. Kelebek H, Selli S, Kadiroğlu P, Kola O, Kesen S, Uçar B, Çetiner B. Bioactive compounds and antioxidant potential in tomato pastes as affected by hot and cold break process. Food Chemistry. 2017 Apr 1; 220:31-41. https://doi.org/10.1016/j.foodchem.2016.09.190
25. Bhatkar NS, Shirkole SS, Mujumdar AS, Thorat BN. Drying of tomatoes and tomato processing waste: a critical review of the quality aspects. Drying Technology. 2021 Aug 2; 39(11):1720-44. https://doi.org/10.1080/07373937.2021.1910832
26. Paulino SL, Adrián ÁT, Gabriela EA, Maribel VM, Sergio MG. Nutraceutical potential of flours from tomato by-product and tomato field waste. Journal of Food Science and Technology. 2020 Sep; 57(9):3525-31. https://doi.org/10.1007/s13197-020-04585-1
27. Lu, Z.; Wang, J.; Gao, R.; Ye, F.; Zhao, G. Sustainable valorisation of tomato pomace: A comprehensive review. Trends Food Sci. Technol. 2019; 86:172-187 https://doi.org/10.1016/j.tifs.2019.02.020
28. Domínguez R, Gullón P, Pateiro M, Munekata PE, Zhang W, Lorenzo JM. Tomato as potential source of natural additives for meat industry. A review. Antioxidants. 2020 Jan 15; 9(1):73. https://doi.org/10.3390/antiox9010073
29. He Y, Wang B, Wen L, Wang F, Yu H, Chen D, Su X, Zhang C. Effects of dietary fiber on human health. Food Science and Human Wellness. 2022 Jan 1; 11(1):1-0. https://doi.org/10.1016/j.fshw.2021.07.001
30. Salehi B, Sharifi-Rad R, Sharopov F, Namiesnik J, Roointan A, Kamle M, Kumar P, Martins N, Sharifi-Rad J. Beneficial effects and potential risks of tomato consumption for human health: An overview. Nutrition. 2019 Jun 1; 62:201-8. https://doi.org/10.1016/j.nut.2019.01.012
31. Suganandam K, Jeevalatha A, Kandeepan C, Kavitha N, Senthilkumar N, Sutha S, Seyed MA, Gandhi S, Ramya S, Pushpalatha GG, Abraham GC. Profile of Phytochemicals and GCMS Analysis of Bioactive Compounds in Natural Dried-Seed Removed Ripened Pods Methanolic Extracts of Moringa oleifera. Journal of Drug Delivery and Therapeutics. 2022 Oct 15; 12(5-S):133-41. https://doi.org/10.22270/jddt.v12i5-S.5657
32. Ramya S, Loganathan T, Chandran M, Priyanka R, Kavipriya K, Pushpalatha GG, Aruna D, Ramanathan L, Jayakumararaj R, Saluja V. Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil. Journal of Drug Delivery and Therapeutics. 2022 Apr 15; 12(2-S):110-118. https://doi.org/10.22270/jddt.v12i2-S.5280
33. Vijaya V, Selvi BK, John PJ, Ramya S, Jayakumararaj R. Phytochemical Screening, GC-MS and FTIR analysis of Bioactive Compounds in Methanolic Leaf Extracts of Costus igneus (CIMLE) as a Natural Source of Drug Lead Molecules for Next-generation Drug-design, Development and Therapeutics. Journal of Drug Delivery and Therapeutics. 2022 Oct 17; 12(5-S):142-55. https://doi.org/10.22270/jddt.v12i5-S.5658
34. Kandeepan C, Sabitha M, Parvathi K, Senthilkumar N, Ramya S, Boopathi NM, Jayakumararaj R. Phytochemical Screening, GCMS Profile, and In-silico properties of Bioactive Compounds in Methanolic Leaf Extracts of Moringa oleifera. Journal of Drug Delivery and Therapeutics. 2022 Mar 15; 12(2):87-99. https://doi.org/10.22270/jddt.v12i2.5250
35. Lydial PG, Abraham GC. Phytochemical screening and GC-MS analysis of bioactive compounds in Caesalpinia bonduc L. from Alagarkovil Reserve Forest (ARF), Dindigul District, South India. Journal of Drug Delivery and Therapeutics. 2022 Aug 15; 12(4-S):43-52. https://doi.org/10.22270/jddt.v12i4-S.5491
36. Loganathan T, Barathinivas A, Soorya C, Balamurugan S, Nagajothi TG, Jayakumararaj R. GCMS Profile of Bioactive Secondary Metabolites with Therapeutic Potential in the Ethanolic Leaf Extracts of Azadirachta indica¬: A Sacred Traditional Medicinal Plant of INDIA. Journal of Drug Delivery and Therapeutics. 2021 Aug 15; 11(4-S):119-26. https://doi.org/10.22270/jddt.v11i4-S.4967
37. Jeevalatha A, Kalaimathi RV, Basha AN, Kandeepan C, Ramya S, Loganathan T, Jayakumararaj R. Profile of bioactive compounds in Rosmarinus officinalis. Journal of Drug Delivery and Therapeutics. 2022 Jan 15; 12(1):114-22. https://doi.org/10.22270/jddt.v12i1.5189
38. Ramya S, Neethirajan K, Jayakumararaj R. Profile of bioactive compounds in Syzygium cumini-a review. J. Pharm. Res. 2012 Aug; 5(8):4548-53.
39. Chandran M, Priyanka R, Kavipriya D, Ramya S, Jayakumararaj R, Loganathan T, Pandiarajan G, Kaliraj P, Pushpalatha GG, Abraham GC, Dhakar RC. Reformulation and Scientific Evaluation of CUSOCO: A Traditional Toothpaste Formula from Classical Tamil Literature towards treatment of Halitosis. Journal of Drug Delivery and Therapeutics. 2022 Sep 15; 12(5):127-31. https://doi.org/10.22270/jddt.v12i5.5604
40. Ramya S. Jayakumararaj R. Phytochemical screening and antibacterial activity of leaf extracts of Pterocarpus marsupium Roxb.(Fabaceae). Ethnobotanical Leaflets. 2008; 2008(1):136.
41. Vats S, Bansal R, Rana N, Kumawat S, Bhatt V, Jadhav P, Kale V, Sathe A, Sonah H, Jugdaohsingh R, Sharma TR. Unexplored nutritive potential of tomato to combat global malnutrition. Critical Reviews in Food Science and Nutrition. 2022 Feb 21; 62(4):1003-34. https://doi.org/10.1080/10408398.2020.1832954
42. Faria-Silva C, Sousa M, Carvalheiro MC, Simões P, Simões S. Alpha-tomatine and the two sides of the same coin: an anti-nutritional glycoalkaloid with potential in human health. Food Chemistry. 2022 May 20:133261. https://doi.org/10.1016/j.foodchem.2022.133261
43. Sarkar T, Salauddin M, Roy A, Sharma N, Sharma A, Yadav S, Jha V, Rebezov M, Khayrullin M, Thiruvengadam M, Chung IM. Minor tropical fruits as a potential source of bioactive and functional foods. Critical Reviews in Food Science and Nutrition. 2022; 4:1-45. https://doi.org/10.1080/10408398.2022.2033953
44. Soorya C, Balamurugan S, Ramya S, Neethirajan K, Kandeepan C, Jayakumararaj R. Physicochemical, ADMET and Druggable properties of Myricetin: A Key Flavonoid in Syzygium cumini that regulates metabolic inflammations. Journal of Drug Delivery and Therapeutics. 2021 Jul 15; 11(4):66-73. https://doi.org/10.22270/jddt.v11i4.4890
45. Krishnaveni K, Murugan M, Kalaimathi RV, Basha AN, Pallan GA, Kandeepan C, Senthilkumar N, Mathialagan B, Ramya S, Jayakumararaj R, Loganathan T. ADMET informatics of Plant Derived n-Hexadecanoic Acid (Palmitic Acid) from ethyl acetate fraction of Moringa oleifera leaf extract. Journal of Drug Delivery and Therapeutics. 2022 Sep 15; 12(5):132-45. https://doi.org/10.22270/jddt.v12i5.5605
46. Loganathan T, Barathinivas A, Soorya C, Balamurugan S, Nagajothi TG, Ramya S, Jayakumararaj R. Physicochemical, Druggable, ADMET Pharmacoinformatics and Therapeutic Potentials of Azadirachtin-a Prenol Lipid (Triterpenoid) from Seed Oil Extracts of Azadirachta indica A. Juss. Journal of Drug Delivery and Therapeutics. 2021 Sep 15; 11(5):33-46. https://doi.org/10.22270/jddt.v11i5.4981
47. Kalaimathi RV, Krishnaveni K, Murugan M, Basha AN, Gilles AP, Kandeepan C, Senthilkumar N, Mathialagan B, Ramya S, Ramanathan L, Jayakumararaj R. ADMET informatics of Tetradecanoic acid (Myristic Acid) from ethyl acetate fraction of Moringa oleifera leaves. Journal of Drug Delivery and Therapeutics. 2022 Aug 20; 12(4-S):101-11. https://doi.org/10.22270/jddt.v12i4-S.5533
48. Ramya S, Murugan M, Krishnaveni K, Sabitha M, Kandeepan C, Jayakumararaj R. In-silico ADMET profile of Ellagic Acid from Syzygium cumini: A Natural Biaryl Polyphenol with Therapeutic Potential to Overcome Diabetic Associated Vascular Complications. Journal of Drug Delivery and Therapeutics. 2022 Jan 15; 12(1):91-101. https://doi.org/10.22270/jddt.v12i1.5179
49. Ramya S, Loganathan T, Chandran M, Priyanka R, Kavipriya K, Pushpalatha GL, Aruna D, Abraham GC, Jayakumararaj R. ADME-Tox profile of Cuminaldehyde (4-Isopropylbenzaldehyde) from Cuminum cyminum seeds for potential biomedical applications. Journal of Drug Delivery and Therapeutics. 2022 Apr 15; 12(2-S):127-41. https://doi.org/10.22270/jddt.v12i2-S.5286
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