Reformulation and Scientific Evaluation of CUSOCO: A Traditional Toothpaste Formula from Classical Tamil Literature towards treatment of Halitosis

Authors

  • M. Chandran Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632115, INDIA
  • R. Priyanka Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632115, INDIA
  • D. Kavipriya Department of Zoology, Arignar Anna Government Arts College for Women, Walajapet, TN, INDIA
  • S. Ramya PG Department of Zoology, Yadava College (Men), Thiruppalai - 625014, Madurai, TN, India
  • R. Jayakumararaj Department of Botany, Government Arts College, Melur – 625106, Madurai District, TN, India
  • T. Loganathan Department of Botany, Government Arts College, Melur – 625106, Madurai District, TN, India
  • G. Pandiarajan Department of Botany, Sri S Ramasamy Naidu Memorial College (A), Sattur - 626203 TN, India
  • P. Kaliraj Department of Zoology, Sri S Ramasamy Naidu Memorial College (A), Sattur - 626203 TN, India
  • G Grace Lydial Pushpalatha PG Department of Botany, Sri Meenakshi Government Arts College, Madurai – 625002, TN, India
  • GC. Abraham PG & Research Department of Botany, The American College, Madurai – 625002, TamilNadu, India
  • Ram Chand Dhakar Hospital Pharmacy, SRG Hospital & Medical College Jhalawar-326001, Rajasthan, India https://orcid.org/0000-0001-8250-8489

Abstract

In order to achieve the multi-claim products required for dental-health-care and hygiene, it is indispensable for the formulator to use a wide range of ingredients however, with the advent of technology the chemically synthesised products are not of demand in the market as they have side effects and are considered to unsafe for human use. This places quite a number of demands on the use of PBNPs in the development process. Use of PBNPs innovations in the areas of pharmaceutical technology have contributed significantly to the formulation of dental-health-care products with superior efficacy as well as other attributes that may contribute to clinical response and patient acceptability. Improved clinical efficacy and tolerability, along with conditioning signals, should encourage patient compliance with oral hygiene. Cuminum cyminum seeds are being habitually used in traditional cuisines of different cultures. In India, it is used in both whole and ground form as a traditional ingredient to make dishes without perceptive medicinal knowledge/ properties behind. In Kerala, decoction of cumin seeds is used for drinking (Jeera water). In Tamilnadu, cumin seeds are the key ingredient of Rasam. Fruit of Solanum lycopersicum is one of the important savoury vegetable used in traditional Indian cuisines. The oil of Cocos nucifera fruits are used in cooking in Kerala and TamilNadu. In the present study, composition (paste) prepared by mixing of 2 drops of S. lycopersicum fruit juice, 2 drops of C. nucifera and 1g of C. cyminum seed powder were tested on 100 subjects with felt bad breath. Results of the present study was found to be effective in controlling bad breath (odour) in 74 subjects after the treatment (period of clinical trial) except 09 of 83 subjects who were diabetic.

Keywords: Oral hygiene; bad breath; halitosis; Cuminum cyminum; Solanum lycopersicum; Cocos nucifera; CUSOCO; dental-health-care

Keywords:

Oral hygiene, bad breath, halitosis, Cuminum cyminum, Solanum lycopersicum, Cocos nucifera, CUSOCO, dental-health-care

DOI

https://doi.org/10.22270/jddt.v12i5.5604

Author Biographies

M. Chandran, Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632115, INDIA

Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632115, INDIA

R. Priyanka, Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632115, INDIA

Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632115, INDIA

D. Kavipriya, Department of Zoology, Arignar Anna Government Arts College for Women, Walajapet, TN, INDIA

Department of Zoology, Arignar Anna Government Arts College for Women, Walajapet, TN, INDIA

S. Ramya, PG Department of Zoology, Yadava College (Men), Thiruppalai - 625014, Madurai, TN, India

PG Department of Zoology, Yadava College (Men), Thiruppalai - 625014, Madurai, TN, India

R. Jayakumararaj, Department of Botany, Government Arts College, Melur – 625106, Madurai District, TN, India

Department of Botany, Government Arts College, Melur – 625106, Madurai District, TN, India

T. Loganathan, Department of Botany, Government Arts College, Melur – 625106, Madurai District, TN, India

Department of Botany, Government Arts College, Melur – 625106, Madurai District, TN, India

G. Pandiarajan, Department of Botany, Sri S Ramasamy Naidu Memorial College (A), Sattur - 626203 TN, India

Department of Botany, Sri S Ramasamy Naidu Memorial College (A), Sattur - 626203 TN, India

P. Kaliraj, Department of Zoology, Sri S Ramasamy Naidu Memorial College (A), Sattur - 626203 TN, India

Department of Zoology, Sri S Ramasamy Naidu Memorial College (A), Sattur - 626203 TN, India

G Grace Lydial Pushpalatha, PG Department of Botany, Sri Meenakshi Government Arts College, Madurai – 625002, TN, India

PG Department of Botany, Sri Meenakshi Government Arts College, Madurai – 625002, TN, India

GC. Abraham, PG & Research Department of Botany, The American College, Madurai – 625002, TamilNadu, India

PG & Research Department of Botany, The American College, Madurai – 625002, TamilNadu, India

Ram Chand Dhakar, Hospital Pharmacy, SRG Hospital & Medical College Jhalawar-326001, Rajasthan, India

Hospital Pharmacy, SRG Hospital & Medical College Jhalawar-326001, Rajasthan, India

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Published

15-09-2022
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How to Cite

1.
Chandran M, Priyanka R, Kavipriya D, Ramya S, Jayakumararaj R, Loganathan T, et al. Reformulation and Scientific Evaluation of CUSOCO: A Traditional Toothpaste Formula from Classical Tamil Literature towards treatment of Halitosis. J. Drug Delivery Ther. [Internet]. 2022 Sep. 15 [cited 2025 May 25];12(5):127-31. Available from: https://jddtonline.info/index.php/jddt/article/view/5604

How to Cite

1.
Chandran M, Priyanka R, Kavipriya D, Ramya S, Jayakumararaj R, Loganathan T, et al. Reformulation and Scientific Evaluation of CUSOCO: A Traditional Toothpaste Formula from Classical Tamil Literature towards treatment of Halitosis. J. Drug Delivery Ther. [Internet]. 2022 Sep. 15 [cited 2025 May 25];12(5):127-31. Available from: https://jddtonline.info/index.php/jddt/article/view/5604

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