Reformulation and Scientific Evaluation of CUSOCO: A Traditional Toothpaste Formula from Classical Tamil Literature towards treatment of Halitosis
Abstract
In order to achieve the multi-claim products required for dental-health-care and hygiene, it is indispensable for the formulator to use a wide range of ingredients however, with the advent of technology the chemically synthesised products are not of demand in the market as they have side effects and are considered to unsafe for human use. This places quite a number of demands on the use of PBNPs in the development process. Use of PBNPs innovations in the areas of pharmaceutical technology have contributed significantly to the formulation of dental-health-care products with superior efficacy as well as other attributes that may contribute to clinical response and patient acceptability. Improved clinical efficacy and tolerability, along with conditioning signals, should encourage patient compliance with oral hygiene. Cuminum cyminum seeds are being habitually used in traditional cuisines of different cultures. In India, it is used in both whole and ground form as a traditional ingredient to make dishes without perceptive medicinal knowledge/ properties behind. In Kerala, decoction of cumin seeds is used for drinking (Jeera water). In Tamilnadu, cumin seeds are the key ingredient of Rasam. Fruit of Solanum lycopersicum is one of the important savoury vegetable used in traditional Indian cuisines. The oil of Cocos nucifera fruits are used in cooking in Kerala and TamilNadu. In the present study, composition (paste) prepared by mixing of 2 drops of S. lycopersicum fruit juice, 2 drops of C. nucifera and 1g of C. cyminum seed powder were tested on 100 subjects with felt bad breath. Results of the present study was found to be effective in controlling bad breath (odour) in 74 subjects after the treatment (period of clinical trial) except 09 of 83 subjects who were diabetic.
Keywords: Oral hygiene; bad breath; halitosis; Cuminum cyminum; Solanum lycopersicum; Cocos nucifera; CUSOCO; dental-health-care
Keywords:
Oral hygiene, bad breath, halitosis, Cuminum cyminum, Solanum lycopersicum, Cocos nucifera, CUSOCO, dental-health-careDOI
https://doi.org/10.22270/jddt.v12i5.5604References
Aspinall SR, Parker JK, Khutoryanskiy VV. Oral care product formulations, properties and challenges. Colloids and Surfaces B: Biointerfaces. 2021 Apr 1; 200:111567 https://doi.org/10.1016/j.colsurfb.2021.111567
Naidoo S. Oral health and nutrition. Oral Health Care-Prosthodontics, periodontology, Biology, Research and Systemic Conditions. 2012 Feb 29 https://doi.org/10.5772/33921
Buunk‐Werkhoven YA, Dijkstra‐le Clercq M, Verheggen‐Udding EL, De Jong N, Spreen M. Halitosis and oral health‐related quality of life: a case report. International journal of dental hygiene. 2012 Feb; 10(1):3-8. https://doi.org/10.1111/j.1601-5037.2011.00512.x
Cortelli JR, Barbosa MD, Westphal MA. Halitosis: a review of associated factors and therapeutic approach. Brazilian oral research. 2008; 22:44-54 https://doi.org/10.1590/S1806-83242008000500007
Ueno M, Yanagisawa T, Shinada K, Ohara S, Kawaguchi Y. Prevalence of oral malodor and related factors among adults in Akita Prefecture. Journal of medical and dental sciences. 2007; 54(3):159-65
Liu XN, Shinada K, Chen XC, Zhang BX, Yaegaki K, Kawaguchi Y. Oral malodor‐related parameters in the Chinese general population. Journal of clinical periodontology. 2006 Jan; 33(1):31-6 https://doi.org/10.1111/j.1600-051X.2005.00862.x
Morita M, Wang HL. Association between oral malodor and adult periodontitis: a review. Journal of clinical periodontology. 2001 Sep; 28(9):813-9 https://doi.org/10.1034/j.1600-051x.2001.028009813.x
Scully C, Felix DH. Oral medicine-update for the dental practitioner: dry mouth and disorders of salivation. British dental journal. 2005 Oct; 199(7):423-7 https://doi.org/10.1038/sj.bdj.4812740
Hoshi K, Yamano Y, Mitsunaga A, Shimizu S, Kagawa J, Ogiuchi H. Gastrointestinal diseases and halitosis: association of gastric Helicobacter pyloriinfection. International dental journal. 2002 Jun; 52 (S5P1):207-11 https://doi.org/10.1002/j.1875-595X.2002.tb00926.x
Tonzetich J. Oral malodour. An indicator of health status and oral cleanliness. Int Dent J.. 1978; 28:309-19
Yaegaki K, Coil JM. Examination, classification, and treatment of halitosis; clinical perspectives. Journal-canadian dental association. 2000 May 1; 66(5):257-61
Oho T, Yoshida Y, Shimazaki Y, Yamashita Y, Koga T. Characteristics of patients complaining of halitosis and the usefulness of gas chromatography for diagnosing halitosis. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2001 May 1; 91(5):531-4 https://doi.org/10.1067/moe.2001.112543
Söder B, Johansson B, Söder PO. The relation between foetor ex ore, oral hygiene and periodontal disease. Swedish dental journal. 2000 Jan 1; 24(3):73-82.
Chattopadhyay I, Lu W, Manikam R, Malarvili MB, Ambati RR, Gundamaraju R. Can metagenomics unravel the impact of oral bacteriome in human diseases?. Biotechnology and Genetic Engineering Reviews. 2022 Jul 23:1-33 https://doi.org/10.1080/02648725.2022.2102877
Tonzetich J. Production and origin of oral malodor: a review of mechanisms and methods of analysis. Journal of periodontology. 1977 Jan 1; 48(1):13-20. https://doi.org/10.1902/jop.1977.48.1.13
Cortelli JR, Barbosa MD, Westphal MA. Halitosis: a review of associated factors and therapeutic approach. Brazilian oral research. 2008; 22:44-54 https://doi.org/10.1590/S1806-83242008000500007
Asokan S, Kumar RS, Emmadi P, Raghuraman R, Sivakumar N. Effect of oil pulling on halitosis and microorganisms causing halitosis: A randomized controlled pilot trial. Journal of Indian Society of Pedodontics and Preventive Dentistry. 2011 Apr 1; 29(2):90 https://doi.org/10.4103/0970-4388.84678
Bosy A. Oral malodor: philosophical and practical aspects. Journal (Canadian Dental Association). 1997 Mar 1; 63(3):196-201
Tonzetich J. Production and origin of oral malodor: a review of mechanisms and methods of analysis. Journal of periodontology. 1977 Jan 1; 48(1):13-20 https://doi.org/10.1902/jop.1977.48.1.13
Yuan H, Ma Q, Ye L, Piao G. The traditional medicine and modern medicine from natural products. Molecules. 2016; 21(5):559. https://doi.org/10.3390/molecules21050559
Thomford NE, Senthebane DA, Rowe A, Munro D, Seele P, Maroyi A, Dzobo K. Natural products for drug discovery in the 21st century: innovations for novel drug discovery. International journal of molecular sciences 2018; 19(6):1578. https://doi.org/10.3390/ijms19061578
Atanasov AG, Zotchev SB, Dirsch VM, Supuran CT. Natural products in drug discovery: advances and opportunities. Nature Reviews Drug Discovery 2021; 20(3):200-16. https://doi.org/10.1038/s41573-020-00114-z
Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology advances 2015; 33(8):1582-614. https://doi.org/10.1016/j.biotechadv.2015.08.001
Newman DJ, Cragg GM. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. Journal of Natural Products. 2020; 83(3):770-803. https://doi.org/10.1021/acs.jnatprod.9b01285
Al-Snafi AE. The pharmacological activities of Cuminum cyminum-A review. IOSR Journal of Pharmacy. 2016; 6(6):46-65.
Mnif S, Aifa S. Cumin (Cuminum cyminum L.) from traditional uses to potential biomedical applications. Chem Biodivers. 2015; 12(5):733-42. https://doi.org/10.1002/cbdv.201400305
Nadeem M, Riaz A. Cumin (Cuminum cyminum) as a potential source of antioxidants. Pakistan Journal of Food Sciences. 2012; 22(2):101-7.
Ramya S, Loganathan T, Chandran M, Priyanka R, Kavipriya K, Pushpalatha GG, Aruna D, Ramanathan L, Jayakumararaj R, Saluja V. Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil. Journal of Drug Delivery and Therapeutics. 2022 Apr 15; 12(2-S):110-8. https://doi.org/10.22270/jddt.v12i2-S.5280
Ramya S, Loganathan T, Chandran M, Priyanka R, Kavipriya K, Pushpalatha GL, Aruna D, Abraham GC, Jayakumararaj R. ADME-Tox profile of Cuminaldehyde (4-Isopropylbenzaldehyde) from Cuminum cyminum seeds for potential biomedical applications. Journal of Drug Delivery and Therapeutics. 2022 Apr 15; 12(2-S):127-41. https://doi.org/10.22270/jddt.v12i2-S.5286
World Health Organization. Oral health surveys: basic methods. World Health Organization; 2013
Vranic E, Lacevic A, Mehmedagic A, Uzunovic A. Formulation ingredients for toothpastes and mouthwashes. Bosnian journal of basic medical sciences. 2004 Nov; 4(4):51 https://doi.org/10.17305/bjbms.2004.3362
Hine MK. Halitosis. The Journal of the American Dental Association. 1957 Jul 1; 55(1):37-46 https://doi.org/10.14219/jada.archive.1957.0147
Seemann R, Conceicao MD, Filippi A, Greenman J, Lenton P, Nachnani S, Quirynen M, Roldán S, Schulze H, Sterer N, Tangerman A. Halitosis management by the general dental practitioner-results of an international consensus workshop. Journal of breath research. 2014 Feb 24; 8(1):017101 https://doi.org/10.1088/1752-7155/8/1/017101
Yaegaki K, Sanada K. Effects of a two-phase oil-water mouthwash on halitosis. Clinical preventive dentistry. 1992 Jan 1; 14(1):5-9
Yaegaki K, Coil JM. Examination, classification, and treatment of halitosis; clinical perspectives. Journal-canadian dental association. 2000 May 1; 66(5):257-61
Touyz LZ. Oral malodor-a review. Journal (Canadian Dental Association). 1993 Jul 1; 59(7):607-10
Touyz LZ. Oral malodor: A clinical appraisal: Mechanism, diagnosis & therapy. IOSR-JDMS. 2013; 11:85-9 https://doi.org/10.9790/0853-1168589
Van Ameringen M, Mancini C, Styan G, Donison D. Relationship of social phobia with other psychiatric illness. Journal of affective disorders. 1991 Feb 1; 21(2):93-9 https://doi.org/10.1016/0165-0327(91)90055-W
Schneier FR, Johnson J, Hornig CD, Liebowitz MR, Weissman MM. Social phobia: Comorbidity and morbidity in an epidemiologic sample. Archives of general psychiatry. 1992 Apr 1; 49(4):282-8 https://doi.org/10.1001/archpsyc.1992.01820040034004
Wittchen HU, Fuetsch M, Sonntag H, Müller N, Liebowitz M. Disability and quality of life in pure and comorbid social phobia. Findings from a controlled study. European Psychiatry. 2000; 15(1):46-58 https://doi.org/10.1016/S0924-9338(00)00211-X
Rajmohan M, Madankumar PD, Shivakumar M, Uma KS. Awareness on Oral Health among Ayurvedha and Siddha Practitioners in Chennai, Tamil Nadu-A Questionairre Study. Medical Journal of Islamic World Academy of Sciences. 2012 Apr; 20(2):43-8
Dudzik A, Chomyszyn-Gajewska M. Pseudohalitosis and halitophobia. Przeglad lekarski. 2014 Jan 1; 71(5):274-6
Rassameemasmaung S, Sirikulsathean A, Amornchat C, Hirunrat K, Rojanapanthu P, Gritsanapan W. Effects of herbal mouthwash containing the pericarp extract of Garcinia mangostana L on halitosis, plaque and papillary bleeding index. Journal of the International Academy of Periodontology. 2007 Jan 1; 9(1):19-25
KC HY, Rao V. Evaluation of topical anti-inflammatory effect of Azadirachta indica leaf extract. International Research Journal of Pharmaceutical and Applied Sciences. 2012 Oct 30; 2(5):60-4
El-Hilaly J, Hmammouchi M, Lyoussi B. Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco). Journal of Ethnopharmacology. 2003 Jun 1; 86(2-3):149-58 https://doi.org/10.1016/S0378-8741(03)00012-6
do Egito Vasconcelos BC, Novaes M, Sandrini FA, de Albuquerque Maranhão Filho AW, Coimbra LS. Prevalence of oral mucosa lesions in diabetic patients: a preliminary study. Brazilian journal of otorhinolaryngology. 2008 May 1; 74(3):423-8 https://doi.org/10.1016/S1808-8694(15)30578-4
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