Efficacy and therapeutic rationale of ManahVeda Diabohealth Tablets in Diabetes Care: An Overview
Abstract
Diabetes mellitus is a complex metabolic disorder marked by chronic hyperglycemia and associated with progressive complications affecting multiple organ systems. The limitations of conventional anti-diabetic therapies, including adverse effects and incomplete metabolic control, have driven interest toward holistic and multi-targeted approaches such as Ayurveda. ManahVeda Diabohealth (DH) Tablets are an Ayurvedic proprietary polyherbal formulation developed to support glycemic regulation and metabolic balance through synergistic herbal actions. The formulation contains standardized extracts of Momordica charantia (Karela), Gymnema sylvestre (Gudmar), Syzygium cumini (Jamun), Trigonella foenum-graecum (Fenugreek), Cinnamomum zeylanicum (Cinnamon), Pterocarpus marsupium (Vijaysar), Swertia chirata (Chirayata), Emblica officinalis (Amla), Withania somnifera (Ashwagandha), and Asphaltum punjabianum (Shilajit). These herbs are traditionally recognized for their antihyperglycemic, insulin-sensitizing, antioxidant, anti-inflammatory, and pancreatic protective properties. The therapeutic rationale of Diabohealth Tablets lies in their multi-mechanistic action, including enhancement of insulin secretion, improvement of peripheral glucose uptake, modulation of carbohydrate metabolism, reduction of oxidative stress, and restoration of metabolic homeostasis. From an Ayurvedic perspective, the formulation aids in correcting Agni dysfunction, balancing Kapha and Vata doshas, and addressing the pathophysiology of Madhumeha at both systemic and cellular levels. In addition to glycemic control, the formulation may contribute to improved energy levels, stress modulation, and overall quality of life. Collectively, ManahVeda Diabohealth Tablets represent a rational Ayurvedic intervention for integrative diabetes management. However, well-designed clinical studies are necessary to validate their long-term efficacy, safety, and therapeutic outcomes.
Keywords: Diabetes mellitus; Ayurvedic medicine; Polyherbal formulation; Glycemic control; Madhumeha; ManahVeda Diabohealth Tablets
Keywords:
Diabetes mellitus, Ayurvedic medicine, Polyherbal formulation, Glycemic control, Madhumeha, ManahVeda Diabohealth TabletsDOI
https://doi.org/10.22270/jddt.v16i4.7634References
1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37(Suppl 1):S81-S90. https://doi.org/10.2337/dc14-S081 PMid:24357215
2. DeFronzo RA. Pathogenesis of type 2 diabetes mellitus. Med Clin North Am. 2004;88(4):787-835. https://doi.org/10.1016/j.mcna.2004.04.013 PMid:15308380
3. Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2013;93(1):137-188. https://doi.org/10.1152/physrev.00045.2011 PMid:23303908 PMCid:PMC11042907
4. Eqbal K, Alam MA, Quamri MA, Sofi G, Ahmad Bhat MD. Efficacy of Qurs-e-Gulnar in Ziabetus (type 2 Diabetes Mellitus): a single blind randomized controlled trial. J Complement Integr Med. 2020 Jun 18;18(1):147-153. https://doi.org/10.1515/jcim-2020-0072 PMid:32554837
5. Alam A, Siddiqui MA, Quamri A, Fatima S, Roqaiya M, Ahmad Z. Efficacy of spirulina (Tahlab) in patients of type 2 diabetes mellitus (Ziabetus shakri)-A randomized controlled trial. Journal of Diabetes & Metabolism. 2016 Oct 1;7(10):1-5. https://doi.org/10.4172/2155-6156.1000710
6. Anzar MA, Shamim A, Nafis H, Tanwir MA. Drugs indicated for the management of ziabetus shakri (diabetes mellitus) in unani medicine-An overview. International Journal of Pharmamedix India. 2013 Jul 1;1(3):460-74.
7. Anwer R, Alam A, Khursheed S, Kashif SM, Kabir H, Fatma T. Spirulina: Possible pharmacological evaluation for insulin-like protein. Journal of applied phycology. 2013 Jun;25(3):883-9. https://doi.org/10.1007/s10811-012-9924-z
8. Bailey CJ, Turner RC. Metformin. N Engl J Med. 1996;334(9):574-579. https://doi.org/10.1056/NEJM199602293340906 PMid:8569826
9. Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TPA. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007;40(3):163-173. https://doi.org/10.3164/jcbn.40.163 PMid:18398493 PMCid:PMC2275761
10. Sharma PV. Charaka Samhita. Varanasi: Chaukhambha Orientalia; 2011. Sutrasthana.
11. Tripathi B. Madhava Nidana. Varanasi: Chaukhambha Sanskrit Series Office; 2010.
12. Lad V. Textbook of Ayurveda: Fundamental Principles. Albuquerque: The Ayurvedic Press; 2002.
13. Kessler CS, Michalsen A. Ayurveda in the treatment of type 2 diabetes. Curr Sci. 2012;102(10):1404-1409.
14. Patwardhan B, Warude D, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: A comparative overview. Evid Based Complement Alternat Med. 2005;2(4):465-473. https://doi.org/10.1093/ecam/neh140 PMid:16322803 PMCid:PMC1297513
15. Grover JK, Yadav S, Vats V. Medicinal plants of India with antidiabetic potential. J Ethnopharmacol. 2002;81(1):81-100. https://doi.org/10.1016/S0378-8741(02)00059-4 PMid:12020931
16. Sharma RK, Dash B. Charaka Samhita. Vol 3. Varanasi: Chowkhamba Sanskrit Series Office; 2014. Prameha Nidana and Chikitsa Sthana.
17. Sushruta. Sushruta Samhita. Ambikadatta Shastri, editor. Varanasi: Chaukhambha Sanskrit Sansthan; 2016. Nidana Sthana, Prameha Adhyaya.
18. Vagbhata. Ashtanga Hridaya. Tripathi B, editor. Varanasi: Chaukhambha Sanskrit Pratishthan; 2015. Nidana Sthana.
19. Tripathi B. Madhumeha: Ayurvedic Concept and Management. Varanasi: Chaukhambha Surbharati Prakashan; 2013.
20. Sharma PV. Dravyaguna Vijnana. Vol 1. Varanasi: Chaukhambha Bharati Academy; 2011.
21. Acharya YT. Charaka Samhita with Ayurveda Dipika Commentary. Varanasi: Chaukhambha Orientalia; 2012.
22. Patwardhan B, Mutalik G, Tillu G. Integrative approaches for diabetes management: Ayurvedic perspective. J Ayurveda Integr Med. 2015;6(2):68-75.
23. Kottaimuthu R. Exploring Agni and metabolic disorders: An Ayurvedic interpretation. Anc Sci Life. 2014;33(3):144-149.
24. Shilpa K, Murthy CG. Understanding Prameha through Ayurvedic pathophysiology. AYU. 2011;32(3):289-295. https://doi.org/10.4103/0974-8520.93905 PMid:22529642 PMCid:PMC3326873
25. Lad V. Textbook of Ayurveda: Fundamental Principles. Albuquerque: The Ayurvedic Press; 2002.
26. Sharma H, Chandola HM, Singh G, Basisht G. Utilization of Ayurveda in the management of diabetes mellitus. J Altern Complement Med. 2007;13(9):1021-1028. https://doi.org/10.1089/acm.2007.7017-A PMid:18047449
27. Dwivedi BK, Dwivedi S. Beeja Dosha and hereditary disorders in Ayurveda. J Ayurveda Holist Med. 2016;4(1):22-27.
28. Tiwari PV. Ayurvedic Treatment of Diabetes Mellitus. Delhi: Chaukhambha Orientalia; 2010.
29. Singh RH. Exploring issues in the management of Madhumeha. Anc Sci Life. 2012;31(4):177-184.
30. Payyappallimana U. Role of Ayurveda in metabolic syndrome and diabetes care. J Ayurveda Integr Med. 2010;1(1):45-49. https://doi.org/10.4103/0975-9476.59827 PMid:21829301 PMCid:PMC3149392
31. International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels: International Diabetes Federation; 2021.
32. DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, et al. Type 2 diabetes mellitus. Nat Rev Dis Primers. 2015;1:15019. https://doi.org/10.1038/nrdp.2015.19 PMid:27189025
33. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002;81(1):81-100. https://doi.org/10.1016/S0378-8741(02)00059-4 PMid:12020931
34. Mukherjee PK, Harwansh RK, Bhattacharyya S. Bioavailability of herbal products: approach toward improved pharmacokinetics. Evid Based Complement Alternat Med. 2017;2017:1-11.
35. Banker GS, Anderson NR. Tablets. In: Lachman L, Lieberman HA, Kanig JL, editors. The Theory and Practice of Industrial Pharmacy. 3rd ed. Philadelphia: Lea & Febiger; 1986. p. 293-345.
36. Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G. Rang and Dale's Pharmacology. 8th ed. London: Elsevier; 2016.
37. Williamson EM. Synergy and other interactions in phytomedicines. Phytomedicine. 2001;8(5):401-9. https://doi.org/10.1078/0944-7113-00060 PMid:11695885
38. Wagner H. Synergy research: approaching a new generation of phytopharmaceuticals. Fitoterapia. 2011;82(1):34-7. https://doi.org/10.1016/j.fitote.2010.11.016 PMid:21075177
39. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54(6):1615-25. https://doi.org/10.2337/diabetes.54.6.1615 PMid:15919781
40. Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol. 2004;92(1):1-21. https://doi.org/10.1016/j.jep.2003.12.031 PMid:15099842
41. Patwardhan B, Vaidya AD, Chorghade M. Ayurveda and natural products drug discovery. Curr Sci. 2004;86(6):789-99.
42. Unnikrishnan MK, Rao MN. Oxidative stress and diabetes mellitus. Pharmacol Rev. 1999;51(2):253-74.
43. Tiwari AK, Rao JM. Diabetes mellitus and multiple therapeutic approaches of phytochemicals: present status and future prospects. Curr Sci. 2002;83(1):30-8.
44. Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007;40(3):163-73. https://doi.org/10.3164/jcbn.40.163 PMid:18398493 PMCid:PMC2275761
45. Kamboj VP. Herbal medicine. Curr Sci. 2000;78(1):35-9. https://doi.org/10.1300/J157v01n01_05
46. International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels: International Diabetes Federation; 2021.
47. Sharma AK, Dubey R, Kumar M. Polyherbal formulations in diabetes management: A multi-targeted therapeutic approach. J Ethnopharmacol. 2022;283:114708.
48. Ahmad S, Zaman W, Khan MA. Scientific validation of traditional medicine for metabolic disorders: Current perspectives. J Tradit Complement Med. 2021;11(6):545-553.
49. Patel DK, Kumar R, Laloo D, Hemalatha S. Antidiabetic potential of medicinal plants and their active principles: A review. J Tradit Complement Med. 2020;10(3):250-263.
50. Gupta R, Sharma V, Singh P. Role of herbal medicines in pancreatic β-cell protection and regeneration. Phytother Res. 2021;35(8):4281-4295.
51. Kim YS, Lee YM, Kim H. Natural α-glucosidase and α-amylase inhibitors as antidiabetic agents: Mechanistic insights. Nutrients. 2020;12(7):1922.
52. Alam MA, Uddin R, Subhan N. Herbal insulin sensitizers: Emerging strategies for management of insulin resistance. Biomed Pharmacother. 2022;146:112495.
53. Hardie DG. AMPK: A key regulator of energy balance in diabetes and metabolic syndrome. Nat Rev Endocrinol. 2021;17(7):384-395.
54. Samuel VT, Shulman GI. Mechanisms for insulin resistance: Common threads and missing links. Cell. 2021;184(6):1544-1564.
55. Birben E, Sahiner UM, Sackesen C. Oxidative stress and antioxidant defense mechanisms in diabetes. World J Diabetes. 2020;11(9):315-327.
56. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2021;21(10):643-655.
57. Rani V, Deep G, Singh RK. Oxidative stress and metabolic disorders: Pathophysiological mechanisms and therapeutic strategies. Life Sci. 2020;256:117987.
58. Panossian A, Wikman G. Effects of adaptogens on the central nervous system and molecular mechanisms associated with stress protection. Pharmaceuticals. 2020;13(10):304.
59. Srivastava S, Singh P, Mishra G. Adaptogenic herbs in metabolic stress and endocrine dysfunction. J Ayurveda Integr Med. 2022;13(2):100483.
60. Kaur G, Mehta SK. Lipid-based drug delivery systems for enhanced bioavailability of phytoconstituents. Drug Deliv Transl Res. 2021;11(3):1320-1338.
61. Roy D, Ghosh M, Rangra NK. Herbal approaches to diabetes management: pharmacological mechanisms and omics-driven discoveries. Phytotherapy Research. 2025;39(12):5464-5490. https://doi.org/10.1002/ptr.8410 PMid:39688013
62. Ashagrie YN, Chaubey KK, Tadesse MG, Dayal D, Bachheti RK, Rai N, et al. Antidiabetic phytochemicals: an overview of medicinal plants and their bioactive compounds in diabetes mellitus treatment. Z Naturforsch C J Biosci. 2025;80(9-10):457-479. https://doi.org/10.1515/znc-2024-0192 PMid:39786973
63. Chahrour JA, Chahrour AA, et al. Herbal medicines in the management of diabetes mellitus: cellular mechanisms and clinical perspectives. Biomolecules. 2025;15(12):1674. https://doi.org/10.3390/biom15121674 PMid:41463330 PMCid:PMC12731053
64. Bhatt SM, Sharma N. The potential of various herbal plants for therapeutic treatment for diabetes management. Ann Natl Acad Med Sci (India). 2025;61:213-223. https://doi.org/10.25259/ANAMS_70_2024
65. Swarnkar MD. Herbal medicines in the management of diabetes: ethnobotanical and pharmacological insights. Int J Sci Eng Manage. 2025.
66. Fakhrozi FN, Jofrry SM, Ming LC, Choo CY. Mechanisms of antidiabetic effects of medicinal plants: a systematic review. Curr Trad Med. 2026;12:e22150838239961. https://doi.org/10.2174/0122150838239961240815102258
67. Rampura ZF, Panwar SS. Herbal antidiabetics: an evidence based review of medicinal plants used in type 2 diabetes. J Pharmacogn Phytochem. 2025;14(5):250-257. https://doi.org/10.22271/phyto.2025.v14.i5d.15582
68. International Journal of Herbal Medicine. Herbal remedies for diabetes mellitus: a comprehensive review of medicinal plants and their antidiabetic properties. Int J Herb Med. 2025;13(4):12-17. https://doi.org/10.22271/flora.2025.v13.i4a.992
69. Jadhav A, Neralkar U, Deshmukh J. A conceptual review of Madhumeha according to Ayurveda and contemporary science. J Ayurveda Holistic Med. 2024;12(2). https://doi.org/10.70066/jahm.v12i2.1235
70. African Journal of Biological Sciences. Comprehensive review on Ayurvedic herbal medicine for Prameha (diabetes mellitus). Afr J Biol Sci. 2024;6(4).
71. Singh D, Kar AC. Review of Ayurvedic medicinal plants recommended for the treatment and management of diabetes mellitus. Home Sci J. 2024;10(2). https://doi.org/10.22271/23957476.2024.v10.i2a.1599
72. Sivakumar A. Herbal remedies: a complementary approach to diabetes management. J Pharm Bioallied Sci. 2025. https://doi.org/10.4103/jpbs.jpbs_530_25 PMid:40655710 PMCid:PMC12244820
73. Kurian J, Bilagi A, Deo G. Etiopathogenesis and management of Prameha Poorvaroopa (prediabetes), Prameha and Madhumeha: an ancient perspective. Adv Mind Body Med. 2024;38(3):47-51.
74. International Journal of Ayurveda360. Management of Prameha (Type 2 Diabetes Mellitus) with Ayurveda formulations as adjuvant therapy: a case report. IJOA. 2025;2(2):714-723. https://doi.org/10.63247/3048-7390.vol.2.issue2.4
75. Ayurveda360. Case studies on Ayurvedic adjuvant therapy in diabetes care. Int J Ayurveda360. 2025;2(2). (Related clinical report).
76. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045. Diabetes Res Clin Pract. 2019;157:107843. https://doi.org/10.1016/j.diabres.2019.107843 PMid:31518657
77. Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14(2):88-98. https://doi.org/10.1038/nrendo.2017.151 PMid:29219149
78. Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. Global trends in diabetes complications: a review of current evidence. Diabetologia. 2019;62(1):3-16. https://doi.org/10.1007/s00125-018-4711-2 PMid:30171279
79. Trikkalinou A, Papazafiropoulou AK, Melidonis A. Type 2 diabetes and quality of life. World J Diabetes. 2017;8(4):120-129. https://doi.org/10.4239/wjd.v8.i4.120 PMid:28465788 PMCid:PMC5394731
80. Solli O, Stavem K, Kristiansen IS. Health-related quality of life in diabetes: The associations of complications with EQ-5D scores. Health Qual Life Outcomes. 2010;8:18. https://doi.org/10.1186/1477-7525-8-18 PMid:20132542 PMCid:PMC2829531
81. Bailey CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care. 2019;42(3):409-420.
82. Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TPA. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007;40(3):163-173. https://doi.org/10.3164/jcbn.40.163 PMid:18398493 PMCid:PMC2275761
83. Salehi B, Ata A, V Anil Kumar N, Sharopov F, Ramírez-Alarcón K, Ruiz-Ortega A, et al. Antidiabetic potential of medicinal plants and their active components. Biomolecules. 2019;9(10):551. https://doi.org/10.3390/biom9100551 PMid:31575072 PMCid:PMC6843349
84. Tilburt JC, Kaptchuk TJ. Herbal medicine research and global health: an ethical analysis. Bull World Health Organ. 2008;86(8):594-599. https://doi.org/10.2471/BLT.07.042820 PMid:18797616 PMCid:PMC2649468
85. World Health Organization. WHO global report on traditional and complementary medicine 2019. Geneva: WHO; 2019.
86. Posadzki P, Watson L, Ernst E. Herb-drug interactions: an overview of systematic reviews. Br J Clin Pharmacol. 2013;75(3):603-618. https://doi.org/10.1111/j.1365-2125.2012.04350.x PMid:22670731 PMCid:PMC3575928
87. Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014;4:177. https://doi.org/10.3389/fphar.2013.00177 PMid:24454289 PMCid:PMC3887317
88. Patel SS, Goyal RK. Prevention of diabetes-induced oxidative stress and inflammation by herbal drugs. J Tradit Complement Med. 2011;1(2):87-97.
89. Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691-705. https://doi.org/10.1111/j.1365-2125.2012.04167.x PMid:22486599 PMCid:PMC3403197
90. Al-Rowais NA. Herbal medicine in the treatment of diabetes mellitus. Saudi Med J. 2002;23(11):1327-1331.
91. Patwardhan B, Mutalik G, Tillu G. Integrative approaches for diabetes management: Ayurvedic concepts and modern perspectives. J Ayurveda Integr Med. 2020;11(4):453-458.
92. Dwivedi S, Chopra D. Revisiting Agni in the pathophysiology of metabolic disorders: An Ayurvedic insight. J Ethnopharmacol. 2019;236:236-244.
93. Sharma R, Dash B. Caraka Samhita. Varanasi: Chowkhamba Sanskrit Series Office; 2018. p. 524-531.
94. Tripathi B, Singh RH. Concept of Tridosha in metabolic syndrome and diabetes mellitus. AYU. 2020;41(2):69-75.
95. Verma S, Gupta AK. Role of Dosha imbalance in the development of Madhumeha: A classical review. Int J Ayurveda Res. 2019;10(3):201-207.
96. Mishra LC, Singh BB, Dagenais S. Ayurveda: A historical perspective and principles of metabolic regulation. Altern Ther Health Med. 2018;24(3):32-39.
97. Srikanth N, Rao KP. Ayurvedic management of Madhumeha: Clinical principles and outcomes. J Ayurveda Integr Med. 2021;12(2):231-237.
98. Pandey MM, Rastogi S, Rawat AKS. Indian traditional Ayurvedic system of medicine and nutritional supplementation for diabetes. Evid Based Complement Alternat Med. 2018;2018:3769343.
99. Thakur AK, Semwal DK, Chandra R. Ayurvedic interventions in diabetes mellitus: A systematic review. J Tradit Complement Med. 2020;10(5):455-465.
100. Kaur R, Singh H. Clinical utility of Ayurvedic Rasayana therapy in chronic metabolic disorders. J Ayurveda Holist Med. 2019;7(4):221-228.
101. Prasher B, Gibson G, Mukerji M. Ayurveda and systems biology: Bridging traditional knowledge and modern science. J Ayurveda Integr Med. 2020;11(1):1-8.
102. Tillu G, Chaturvedi S, Chopra A, Patwardhan B. Public health approach of Ayurveda and Yoga for metabolic disorders. J Altern Complement Med. 2018;24(5):453-458.
103. Vaidya ADB, Devasagayam TPA. Current status of herbal drugs in management of diabetes: Mechanistic insights. Indian J Med Res. 2019;150(6):594-603.
104. Shukla VJ, Pandya DH. Role of Dhatu nourishment in preventing complications of Madhumeha. AYU. 2021;42(1):1-7.
105. Narayan JP, Tandon N. Integrative management of diabetes mellitus: Scope of traditional medicine in modern healthcare. Diabetes Metab Syndr. 2022;16(4):102497.
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