An Investigation of Antiepiletic Activity of Plant Extracts in Experimental Animals
Abstract
The current study is done on plant extracts as antiepileptic medication in ayurvedic formulation. The convulsions are induced by electro shock therapy or picrotoxin, strychnine/brucine. After induction of convulsion the plant extract is administered as standard group, control group and simple group of six albino rats and the results are screened and analyzed with standard drug comparision. Pre-treatment of MEIR (methanolic extract of Ipomoea reniformis) for 15days at the dose of 200 and 400 milligram per kilogram body weight was used to evaluate antiepileptic activity. The antiepileptic activity was studied against seizures induced by Maximum electro shock (MES) in rats, Isoniazid (INH) and Pentylenetetrazol (PTZ) in mice.. In pre-treatment studies of antiepileptic activity, MEIR significantly (p<0.01) reduced the tonic hind limb extensor phase in MES model at 400milligram per kilogram body weight, while in INH, PTZ models at the dose of 200 and 400 milligram per kilogram body weight MEIR significantly (p<0.01) delayed the onset of clonic and tonic convulsions. The results of the Pr (+) study suggest that the MEIR possess antiepileptic activity in rats and mice. The results of each activites are compared with standard medicament and evaluated.
Keywords: Ipomoea reniformis, maximal electroshok, isoniazid, pentylenetetazol, convulsions, antiepileptic activity
Keywords:
Ipomoea reniformis, maximal electroshok, isoniazid, pentylenetetazol, convulsions, antiepileptic activityDOI
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