SOLUBLITY ENHANCEMENT OF MICONAZOLE BY FORMULATION OF HYDROTROPIC SOLID DISPERSIONS
Abstract
In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water-soluble drugs. Bulk drug samples were identified by the observed IR spectra and the melting points determination. Sodium benzoate, niacinamide, and urea are the hydrotropes were selected for the solubility enhancement of drugs Solubility enhancement ratios for selected poorly water-soluble drugs were determined. Results showed that remarkable increase in aqueous solubility of Miconazole in presence of large concentration of hydrotropes. Marketed Miconazole tablets determined by spectrophotometric analysis using hydrotropic solubilization techniques. Validation of the proposed analysis methods is confirmed by satisfactorily low values of statistical parameters viz., standard deviation, percent coefficient of variation and standard error.
Keywords: Solubility enhancement, hydrotropes, Solid dispersion, Miconazole.
Â
DOI
https://doi.org/10.22270/jddt.v7i3.1459References
Shelke PV, Dumbare AS, Gadhave MV, Jadhav SL, Sonawane AA, Gaikwad DD, Formulation and evaluation of rapidly dis integrating film of amlodipine bes ylate, Journal of Drug Delivery & Therapeutics; 2012; 2(2):72-75
Singh J, Walia M, Harikumar SL, Solubility enhancement by solid dispersion method: a review, Journal of drug delivery and Therapeutics, 2013; 3(5):148-155
Dalvi PB, Gerange AB, Ingale PR, Solid dispersion: strategy to enhance solubility, Journal of Drug Delivery and Therapeutics. 2015; 5(2):20-28.
George SJ, Vasudevan DT, Studies on the Preparation, Characterization, and Solubility of 2-HP-β-Cyclodextrin-Meclizine HCl Inclusion Complexes, J Young Pharm. 2012; 4(4): 220–227. doi: 10.4103/0975-1483.104365
Krishnaveni B, Chitosan: A review on its varied novel therapeutic and industrial applications, Journal of Drug Delivery and Therapeutics. 2016; 6(6):70-79
Prajapati SK, Maurya SD, Das MK, Tilak VK, Verma KK, Dhakar RC, Dendrimers in drug delivery, diagnosis and therapy: basics and potential applications, Journal of Drug Delivery and Therapeutics. 2016; 6(1):67-92
Chandel P, Kumari R, Kapoor A, Liquisolid technique: an approach for enhancement of solubility, Journal of drug delivery and therapeutics, 2013; 3(4):131-137.
Simamora P, Alvarez JM, Yalkowsky SH, Solubilization of rapamycin, Int J Pharm. 2001; 213(1-2):25-9.
Maheshwari RK, Bishnoi SR, Kumar D, Krishna M. Quantitative spectrophotometric determination of ornidazole tablet formulations using ibuprofen sodium as hydrotropic solubilizing agent Digest .Journal of Nanomaterials and Biostructures. 2009; 4(4):751-754.
Bhirud YD, Phalak HM, Advances in solid dispersion technology and its applications in the development of solid dosage forms, Journal of Drug Delivery & Therapeutics. 2016; 6(6):40-47 DOI: http://dx.doi.org/10.22270/jddt.v6i6.1316
Moneghini M, Kikic I, Voinovich D and Perissutti B. Processing of carbamazepine-PEG 4000 solid dispersions with supercritical carbon dioxide: preparation, characterization, and in vitro dissolution, Int. J. Pharm. 2001; 222(1):129-138.
Published
Abstract Display: 759 
PDF Downloads: 654 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.