FORMULATION AND DEVELOPMENT OF LORNOXICAM BILAYER TABLETS

Authors

  • D R Nagesh Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, India
  • Rakesh Kumar Jat Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, India
  • Syed Mansoor Ahmed Sri Siddaganga College of Pharmacy, B.H. Road, Tumkur 572102 India

Abstract

Point of present examination work was attempted to figure bilayer tablets of lornoxicam through its joining of oral measurements frame that can release lornoxicam promptly in addition maintained sustained release of lornoxicam for 24 hrs to improve oral bioavailability of lornoxicam. Primary target of this work was plan of bilayer tablets utilizing superdisintegrant Kyron 314 for smart discharge layer Polyox 303 for supporting discharge layer made out of two unique classes of medications by utilizing straight forward simple to-scale-up definition system. The in vitro dissolution study of the prepared bilayer tablets showed a controlled release of active drugs over a period of 24 hours

Key Words:  Bilayer Tablets, lornoxicam, Superdisintegrant, sustained release

 

DOI

https://doi.org/10.22270/jddt.v7i6.1534

Author Biographies

D R Nagesh, Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, India

Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, India

Rakesh Kumar Jat, Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, India

Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, India

Syed Mansoor Ahmed, Sri Siddaganga College of Pharmacy, B.H. Road, Tumkur 572102 India

Sri Siddaganga College of Pharmacy, B.H. Road, Tumkur 572102 India

References

Jha MK, Rahman MH and Rahman MM, “Biphasic oral solid drug delivery system: a review.†Int. J. Pharm Sci and Res, 2, 2011, 1108- 1115.

Saravanan V., Revathi R., Meera N. Method development and validation for the simultaneous estimation of lycopene and ubidecarenone by RP-HPLC in combined pharmaceutical dosage form. Journal of Drug Delivery and Therapeutics, 2016; 6(5): 46-51.

Abebe A, Akseli I, Sprockel O, Kottala N, and Cuitino AM, “Review of Bilayer Tablet Technology.†International. J. Pharmaceutics, 461, 2014, 549- 558.

Dagariya RK, Jat RK, Method development and validation of Irbesartan chlorthalidone and Cilnidipine in their combined tablet dosage form by high performance liquid chromatography, Journal of Drug Delivery and Therapeutics. 2017; 7(4):88-96 DOI: http://dx.doi.org/10.22270/jddt.v7i4.1471

Kumar AP, Pramodaganta, Bhoopathi SG and, Kulkarni SV, “Current Innovation in Layered Tablet Technology: Review.†Asian. J. Res pharm. sci. 3, 2013 189-194.

Garg A, Gupta MM, Taste masking and formulation development & evaluation of mouth dissolving tablets of levocetrizine dihydrochloride, Journal of Drug Delivery & Therapeutics; 2013; 3(3):123-130

Cutolo M, Straub RH, Buttgereit F. Circadian rhythms of nocturnal hormones in rheumatoid arthritis: translation from bench to bedside. Ann Rheum Dis 2008; 67 (7):905-908.

Patil S, Gupta V. Design and in vitro evaluation of multiparticulate system for the chronomodulated delivery of lornoxicam. Journal of Drug Delivery and Therapeutics, 2015; 5(3):62-71. doi:10.22270/jddt.v5i3.1148

Merck & Co. Inc. The Merck index. 13th ed. Whitehouse Station: Merck & Co. Inc.; 2001.

Momin S, Khan S, Ghadage DM, Yadav AV, Wagh A, Formulation and evaluation of bilayer tablets of propranolol hydrochloride, Journal of Drug Delivery and Therapeutics. 2017; 7(2)50-57. DOI: http://dx.doi.org/10.22270/jddt.v7i2.1399

Debajyoti Ray, Amresh K Prusty. Designing and invitro studies of gastric floating Tabletss of Tramadol hydrochloride, Int J Appl Pharm. 2010; 2(4):12-16.

Patel K, Vyas J, Upadhyay U. Formulation and evaluation of sustained release matrix tablets of nateglinide. Journal of Drug Delivery and Therapeutics, 2015; 5(5):19-25. doi:10.22270/jddt.v5i5.1130

Agrawal R, Pharmaceutical processing- a review on wet granulation technology. IJPFR. 2011; (1):65-83

Published

28-11-2017
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How to Cite

1.
Nagesh DR, Jat RK, Ahmed SM. FORMULATION AND DEVELOPMENT OF LORNOXICAM BILAYER TABLETS. J. Drug Delivery Ther. [Internet]. 2017 Nov. 28 [cited 2025 Mar. 25];7(6):132-8. Available from: https://jddtonline.info/index.php/jddt/article/view/1534

How to Cite

1.
Nagesh DR, Jat RK, Ahmed SM. FORMULATION AND DEVELOPMENT OF LORNOXICAM BILAYER TABLETS. J. Drug Delivery Ther. [Internet]. 2017 Nov. 28 [cited 2025 Mar. 25];7(6):132-8. Available from: https://jddtonline.info/index.php/jddt/article/view/1534

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