An Overview of Niosomes

  • Pardeep Kaur Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India. https://orcid.org/0009-0007-3338-3676
  • Ritu Rani Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India. https://orcid.org/0009-0009-0013-6016
  • Ajeet Pal Singh Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India. https://orcid.org/0000-0002-1212-5770
  • Amar Pal Singh Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India. http://orcid.org/0000-0003-0027-2869

Abstract

In recent times, there has been a significant shift towards developing targeted biological substances for the treatment of infectious diseases and vaccination. Non-ionic surfactant vesicles, known as niosomes, have emerged as a distinctive vesicular structure in contemporary drug delivery methods due to their biological breakdown, compatibility, chemical resistance, cost-effectiveness, ease of manufacturing and preservation, and low toxicity. The progress in nanocarrier technology has garnered attention for its safety and associated advantages, including enhanced therapeutic administration with diverse pharmacological effects, improved targeting capabilities, and reduced side effects. Niosomes serve as vesicular carriers for drugs, composed of non-ionized surfactants, cholesterol or analogs, and charged molecules that enable controlled and targeted drug delivery. They are categorized as unilamellar, oligolamellar, or multilamellar structures. This comprehensive review article provides an overview of niosomes, covering their structure, types, formulation methods, characterization, advantages and disadvantages, preparation techniques, influencing factors, evaluation criteria, applications, and currently available formulations in the market.


Keywords: Niosomes, drug delivery system, methods of Preparation, Applications.

Keywords: Niosomes, drug delivery system, methods of Preparation, Applications

Downloads

Download data is not yet available.

Author Biographies

Pardeep Kaur, Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Ritu Rani, Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Ajeet Pal Singh, Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Amar Pal Singh, Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

References

1. Singh D, Upadhyay P, Niosomes: a novel vesicular approach, World J Pharmacy Pharm Sci.2016;5(12):1586-92.
2. Dhanvir K, Sandeep K, Niosomes: present scenario and future aspects, Journal of Drug Delivery and Therapeutics (2018):35-43. https://doi.org/10.22270/jddt.v8i5.1886
3. Singh U, Hak J, Sharma UK, A Review on Niosomes novel drug delivery system, International journal for multidisciplinary research (ijfmr),2023:1-7.
4. Gadhiya P, Shukla S, Modi D, Bharadia P, Niosomes in targeted drug delivery :A review, Int J Pharm Res Scho. 2012; 1(2):59-72.
5. Gurjar P, Naik N, Chouksey S, Niosome:A promising pharmaceutical drug delivery, Int J Pharm Analysis, 2014; 2(5):425-31.
6. Verma KN, Rai AK, Gulzar A, Singh AP, Niosomes:An approach to current drug delivery:A review, Int J Adv Pharma, 2017; 06(02):41-8.
7. Katkale, Akshay, Review on niosomes as novel drug delivery system, World Journal of Pharmaceutical Research, 2022, 1137. 10.20959/wjpr20223-23338.
8. Kandpal R, Joshi A, Kumar K, Rajput V, Chauhan V, An updated review on niosomes: a promising drug carrier, International Journal of Indigenous Herbs and Drugs, 2023; 53-57. https://doi.org/10.46956/ijihd.v8i6.512
9. Singh S, Niosomes:A role in targeted drug delivery system, Int J Pharm Sci Res. 2013; 4(2):550-57
10. Gandhi A, Sen SO, Paul A, Current trends in niosome as vesicular drug delivery system. Asian J Pharm LifeSci. 2012; 2(2):339-53
11. Sankhyan A, Pawar P, Recent trends in noisome as vesicular drug delivery system, J Applied Pharm Sci. 2012; 2(6):20-32.
12. Seleci DA, Seleci M, Walter JG, Stah lF, Scheper T, Niosomes as nano particular drug carriers:fundamentals and recent applications, J Nanomaterials, 2016:1-13. https://doi.org/10.1155/2016/7372306
13. Vasistha P, Alpana R, Non-ionic provesicular drug carrier:An overview, Asian J Pharm Clinical Res. 2013; 6(1):38-42.
14. Sonule M, Gandhi M, Paralkar S, Dabhade D, Pagar S, Niosomes: novel drug delivery system, Int J Pure App Bio Sci. 2014;2(2):267-74.
15. Parmar RP, Parmar RB, Conceptual aspects of vesicular drug delivery system with special reference to noisome, Asian J Pharm Tech. 2013; 3(2):52-59.
16. Chandu VP, Arunachalam A, Jeganath S, Yamini K, Tharangini K, Chaitanya G. Niosomes:A novel drug delivery system, Int J novel trends Pharm Sci. 2012; 2(1):25-31.
17. Maurya R, Pathak K, Saxena P, Tiwari J, A review on novel drug delivery system:Niosomes, Asian J Pharm Res Dev 2013; 1(4):51-59.
18. Babu VL, Mathew ST, Jayaveera KN, Prasanth VV, Niosomes:vesicular drug delivery system, Int J Pharm, 2013;3(1):180-85.
19. Kazi MK, Asim SM, Nikhil B, Arijit G, Sugata C, Niosome: A future of targeted drug delivery systems. JA dv Pharm Tech Res, 2010; 1(4):374-80. https://doi.org/10.4103/0110-5558.76435 PMid:22247876 PMCid:PMC3255404
20. Krishnagopal D, Alpana R, Niosome as a novel drug delivery system a review, Int J App Pharm.2014;5(1):1-7.
21. Rahimpour Y, Hamishehkar H, Niosomes as carrier in dermal drug delivery, Recent Adv Novel Drug Carrier System.2012; 141-64. https://doi.org/10.5772/51729
22. Srivastava NS, Thakur S, Kaur J, Niosomes:A novel approach for topical delivery of drugs, Int J PharmTech, 2016;8(2):11712-31.
23. Yadav R, Chanana A, Chawra H, Singh R, Recent Advances in Niosomal Drug Delivery: A Review, International journal of multidisciplinary research, 2023;5(1):1-10 https://doi.org/10.36948/ijfmr.2023.v05i01.1324
24. Shirsand SB, Keshavshetti, Ganesh G, Recent advances in niosomal drug delivery:A review, Research journal of life sciences, bioinformatics,pharmaceuticals and chemical sciences, 2019; 5(3):515-529: https://doi.org/10.26479/2019.0503.43
25. Mehta AK, Dubal AP, Mane PD, Deshmukh HA, Recent trends in niosomes as nanocarriers, Unique J Pharm Bio Sci, 2013; 1(2):12-17.
26. Tangri P, Khurana S, Niosomes:Formulation and evaluation, Int J Biopharma, 2011;2(1):47-53.
27. Keservani RK, Sharma AK,Ayaz MD, Kesharwani RK, Novel drug delivery system for the vesicular delivery of drug by the niosomes, Int J Res Cont Rel,2011; 1(1):1-8.
28. Bagheri A, Chu BS, HarisunY, Niosomal drug delivery systems:Formulation, preparation and applications, WApp Sci Journal, 2014;32 (8):1671-85.
29. Shaji J, Shah A, Niosomes: A novel drug delivery system, W J Pharm Res 2015;4(6):853-76.
30. Vadlamudi CH, Sevukarajan M, Niosomal drug delivery system:A review. Indo AmJ PharmRes.2012;2(9).
31. Sharma P, Jain A P, Pandey P, Gupta R, Roshan S, Niosome a novel approach for drug delivery system: an overview, Asian J Pharm Sci Res.2013; 3(5):18-30.
32. Cummings J, Staurt JF, Calman KC. Determination ofadriamycin, adriamycinol and their 7-deoxyaglycones inhuman serum by high performance liquid chromatography, J Chromatogr, 1984;311:125-33. https://doi.org/10.1016/S0378-4347(00)84698-8 PMid:6520153
33. Kalra N, Jeyabalan G, Niosomes:A versatile drug delivery system, Res J life Sci Bioinformatics Pharm Chem Sci, 2016;2(4):44-54.
34. Gopalakrishnan S, Chenthilnathan A, Niosomes - A novel drug delivery device. Res J Pharm BioChemistry Sci, 2012;3(3):1090-98.
Crossmark
Statistics
74 Views | 7 Downloads
How to Cite
1.
Kaur P, Rani R, Singh AP, Singh AP. An Overview of Niosomes. JDDT [Internet]. 15Mar.2024 [cited 18Apr.2024];14(3):137-46. Available from: https://jddtonline.info/index.php/jddt/article/view/6450