Formulation and Evaluation of Niosomal gel using Tretinoin and Clindamycin combination

Authors

  • Palak Palak Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India
  • Ritu Rani Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India https://orcid.org/0009-0009-0013-6016
  • Rajesh Kumar Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India
  • Ajeet Pal Singh Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India https://orcid.org/0000-0002-1212-5770
  • Amar Pal Singh Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India http://orcid.org/0000-0003-0027-2869

Abstract

The objective of the present study was to formulate topical Niosomal gel loaded with combination of Tretinoin, also known as all-trans retinoic acid (ATRA), and Clindamycin for the beneficial of acne patients, to provide sustained release effects, to prevent their side effects. Purpose of this study was to develop a stable formulation that allows progressive follicle penetration and increased efficacy. Niosomes was prepared by ether injection method. Preformulation studies such as melting point, FTIR spectroscopy, UV spectroscopy, solubility, partition coefficient (log P) were performed for both drugs. In preformulation study, FTIR spectrum reveals that drugs were in pure state. Combination of Tretinoin and clindamycin reveal better therapeutic efficacy and patient compliance as compared to individual agent. From the research findings, it can be concluded that Tretinoin as well as Clindamycin hydrochloride was successfully integrated into niosomal gel by ether injection method for topical application in the treatment of acne.

Keywords: Niosomes; Tretinoin (ALL TRANS RETINOIC ACID); Clindamycin; Carbopol gel; Acne; Ether injection method.

Keywords:

Niosomes, Tretinoin, Clindamycin, Carbopol gel, Acne, Ether injection method

DOI

https://doi.org/10.22270/jddt.v14i3.6477

Author Biographies

Palak Palak, Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India

Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India

Ritu Rani, Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India

Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India

Rajesh Kumar, Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India

Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India

Ajeet Pal Singh, Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India

Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India

Amar Pal Singh, Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India

Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India

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Published

15-03-2024
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How to Cite

1.
Palak P, Rani R, Kumar R, Singh AP, Singh AP. Formulation and Evaluation of Niosomal gel using Tretinoin and Clindamycin combination. J. Drug Delivery Ther. [Internet]. 2024 Mar. 15 [cited 2025 Feb. 18];14(3):106-14. Available from: https://jddtonline.info/index.php/jddt/article/view/6477

How to Cite

1.
Palak P, Rani R, Kumar R, Singh AP, Singh AP. Formulation and Evaluation of Niosomal gel using Tretinoin and Clindamycin combination. J. Drug Delivery Ther. [Internet]. 2024 Mar. 15 [cited 2025 Feb. 18];14(3):106-14. Available from: https://jddtonline.info/index.php/jddt/article/view/6477

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