Assessment of antibacterial activity of some extracts of Securinega virosa (Roxb. ex Willd.) Baill on pathogens bacteria
Today, faced with the emergence of microbial resistance to antibiotics, the renewal of the arsenal of anti-infective drugs is acutely posed. In order to explore other sources of anti-infective drugs, this study therefore proposed to evaluate the antibacterial activity in vitro of several extracts of Securinega virosa, a well-known combretacea of populations in northern Côte d'Ivoire. To achieve this objective, the method of determining the diameters of the zones of inhibition on wells in an agar medium as well as that of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration were carried out. The results showed that the aqueous extract was not active on all the bacteria tested. The dichloromethane fraction at 500 mg/mL inhibited growth of Shigella Typhi (12.5 mm), followed by Streptococcus sp. (12.33 0.25 mm) and Staphylococcus aureus Meti-R (11.75 1.25 mm). The ethyl acetate fraction inhibited primarily Gram-positive bacteria with average diameters of 12 mm to 500 mg/mL. The ethanol fraction was most active on all bacteria with inhibition diameters ranging from 9 to 13.33 mm to 500 mg/mL. It showed the lowest MIC (3.12 mg/mL) on gram-positive and large Gram-negative levels ranging from 12.5 to 50 mg/mL. This study through its results provides data in favor of the traditional use of Securinega virosa in therapy.
Keywords : Securinega virosa, in vitro, antibacterial, activity
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