Effect of Ethanolic Fraction of Anogeissus Leiocarpa on Renal Function in Wistar Rat
Abstract
Objective : This study investigated the effects of acute administration of ethanolic extract of Anogeissus leiocarpa on renal function in Wistar rats.
Materials and Methods : Wistar albino spawn and Anogeissus leiocarpa root bark were used as biological material for this study. The method employed was to administer single doses of ethanolic extract of Anogeissus leiocarpa root bark orally. Urine and blood samples were collected followed by measurement of renal markers (blood and urine urea and creatinine levels, urea and creatinine clearance).
Results: Serum urea and creatinine levels were unchanged compared with controls. In contrast, extract and furosemide caused a significant (p < 0.001), dose-dependent increase in urinary creatinine. Ethanolic extract of Anogeissus leiocarpa, at doses of 300 and 500 mg/kg bw, significantly increased creatinine and urea clearance and thus glomerular filtration rate.
Conclusion : Levels and clearances of urea and creatinine, kidney biomarkers, were not altered. This study shows that the extract is not nephrotoxic.
Keywords : Anogeissus leiocarpa, glomerular filtration rate, nephrotoxic, urea, creatinine
Keywords:
Anogeissus leiocarpa, glomerular filtration rate, nephrotoxic, urea, creatinineDOI
https://doi.org/10.22270/jddt.v13i12.6157References
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