Phenytoin Induced Cerebral Atrophy: A Case Report
Abstract
Phenytoin is the most common drug prescribed in patient diagnosed with seizure. Cerebral atrophy is an observed complication in phenytoin exposed patients. The side effects related to phenytoin administration include sedation, dizziness, swaying, rash and gum hypertrophy. In the following case report a 50-year-old male patient with complaints of poor response to oral commands, slurred speech, limited upper limb movements and neck rigidity, the patient is a known epileptic since 1 year on prescription and is alcoholic. Upon CT scan of brain, the impression was mild diffuse cerebellar atrophy probably due to long term phenytoin use. Hence frequent phenytoin level monitoring in patient prescribed with the same is mandatory.
Keywords: phenytoin, epilepsy, cerebral atrophy
Keywords:
phenytoin, epilepsy, cerebral atrophyDOI
https://doi.org/10.22270/jddt.v12i5.5640References
Kodam V, Srinivas DS, Sanda MR, Kanni YS, Venkat KT, Shravan, Phenytoin Induced Cerebellar Atrophy - A Case Report, JBCR, 2016; 3(2) https://jbcr.net.in/volume3-issue2-casereport3.htm
Satheesh G, Varma S, Antony A. Case Report on Phenytoin Induced Cerebellar Syndrome. Indian Journal of Pharmacy Practice. 2018; 11:58-60. DOI:10.5530/ijopp.11.1.11
De Marcos FA, Ghizoni E, Kobayashi E, Li LM, Cendes F. Cerebellar volume and long-term use of phenytoin. Seizure. 2003 Jul; 12(5):312-5. DOI: 10.1016/s1059-1311(02)00267-4 PMID: 12810345.
Cerebral Atrophy (Brain Atrophy): Symptoms, Causes, and Diagnosis (healthgrades.com)
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