Silver Sulfadiazine: Action on Burn Wound Sepsis and Infections

Authors

  • Satwinder Singh Walia Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Punjab, India
  • D.N. Prasad Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

Abstract

The purpose of this systematic review and meta-review has shifted from assessing the consequences of silver sulfadiazine with most different drugs (SSD) for burn recovery and contamination prevention to different novel dressings, without or with silver. Burn units have to be able to better control sepsis. The degree to which a burn topical antibacterial agent is absorbed determines its effectiveness. Absorption of a topical antibacterial agent may be evaluated against the absorption of a test solute in isolated preparation of the stratum corneum in a cell in an in vitro model. Despite the fact that adding silver sulfadiazine (AgSu) to pure deoxyribonucleic acid (DNA) resulted in the formation of silver sulfadiazine (AgSu)the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu. In treated bacteria, AgSu inhibited macromolecular syntheses as DNA synthesis was slightly more sensitive. A tiny amount of sulfadiazine appears to be active in this situation. Pediatric patients were randomly assigned to treatment with either Silva-Sorb® Gel or Silvadene® silver sulfadiazine cream for up to 21 days or to the point of full reepithelialization of the wound.

Keyword: Silver, Sulfadiazine, Silvasorb, Bacteria, Burn, Wound.

Keywords:

Silver, Sulfadiazine, Silvasorb, Bacteria, Burn, Wound

DOI

https://doi.org/10.22270/jddt.v12i4.5419

Author Biographies

Satwinder Singh Walia, Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Punjab, India

Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Punjab, India

D.N. Prasad, Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

References

Mater BJ. Silver-and Sulfadiazine-loaded nanostructured silica materials as potentialreplacement of silver sulfadiazine. Journel of materials chemistry. 2014; 2:6283. https://doi.org/10.1039/C4TB00619D

Herndon DN, Hawkins HK, Lee JO,Cox, RA,Kulp, GA,Finnerty CC, Chinkes DL, Jeschke MG, Williams FN. The leading causes of death after burn after injury in a single pediatric burn center. Critical Care (London,England). 2009; 13(6) https://doi.org/10.1186/cc8170

Atiyeh BS, Costagliola M, Hayek SN, et al. Effect of silver on burn wound infection control and healing. Review of the literature. Burns 2007; 33:139-148. https://doi.org/10.1016/j.burns.2006.06.010

Abdullah ZW, Dong Y, Han N, et al. Water and gas barrier properties of polyvinyl alcohol (PVA)/starch (ST)/glycerol (GL)/halloysite nanotube (HNT) bionanocomposite films. Experimental characterisation and modelling Compos Part B: Eng 2019; 174:107033. https://doi.org/10.1016/j.compositesb.2019.107033

Nejaddehbashi F, Hashemitabar M, Bayati V, et al. Incorporation of silver sulfadiazine into an electrospun composite of polycaprolactone as an antibacterial scaffold for wound healing in rats. Cell J 2020; 21:379-390.

Stavitskaya A, Batasheva S, Vinokurov V, et al.Antimicrobial applications of clay nanotube-based composites. Nanomaterials 2019; 9:708-720. https://doi.org/10.3390/nano9050708

Vincenzo B, Riccio F, Klosowski AB, et al. Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery. J Appl Polym Sci 2021.

Graziele Louize Policarpio da Silva, Juliana Bonametti Olivato, Juliano Marini, Priscileila Colerato Ferrari. Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites. Journal of Biomaterials Applications. 2021; 35(9):1096-11086. https://doi.org/10.1177/0885328221995920

Christie J, Liu Z, Westby MJ, Jefferies JM, Hudson T, Edwards J, Mohapatra DP, Hassan IA, Dumville JC, Normal G. Antiseptics for burns. The Cochrane database of systematic review.2017; 7:31-32.

Zhang H, Peng M, et al. Silver nanoparticles-doped collagen-alginate antimicrobial biocomposite as potential wound dressing. Journal of materials science. 2018; 53(21):14944-14952. https://doi.org/10.1007/s10853-018-2710-9

Hebeish A, et al. Antimicrobial wound dressing and anti-inflammatory efficacy of silver nanoparticles. International journal of biological macromolecules. 2014; 65:509-515. https://doi.org/10.1016/j.ijbiomac.2014.01.071

Saghazadeh S, Rinoldi C, Schot M, Kashaf S.S, Sharifi F, Yue K, Khademhosseini A. Drug delivery systems and materials for wound healing applications. Adv Drug Deliv Rev. 2018; 127:138-166. https://doi.org/10.1016/j.addr.2018.04.008

Shah S.A, Sohail M, Khan S, Minhas M.U, Matas M.D, Kousar M. Biopolymer-based biomaterials for accelerated diabetic wound healing.A critical review.Int J Biol Macromol. 2019; 139:975-993. https://doi.org/10.1016/j.ijbiomac.2019.08.007

Lvov Y and Abdullayev E. Functional polymer-clay nanotube composites with sustained release of chemical agents. Prog Polym Sci 2013; 38:1690-1719. https://doi.org/10.1016/j.progpolymsci.2013.05.009

Malakinezhad H, Kalaee M, Abdouss M, et al. Fabrication and characterization of biodegradable Ph Responsive halloysite poly(lactic-co-glycolic acid)micro-sphere for controlled released of phenytoin sodium. J Inorg Organomet Polym Mater. 2020; 30:722-730. https://doi.org/10.1007/s10904-019-01263-4

Arroyo AG, Iruela-Arispe ML (2010) Extracellular matrix, inflammation, and the angiogenic response. Cardiovascular Research.2010; 86:226-235. https://doi.org/10.1093/cvr/cvq049

Eldad A, Icekson M, Zur T, et al. Silver-sulphadiazine eschar pigmentationa mimics invasive wound infection. J Burn Care Rehabil.2003; 24:154-7. https://doi.org/10.1097/01.BCR.0000069440.78932.70

Tsai TC, Peng SK, Shih YR, Luk HN. Sulfadiazine-induced methemoglobinemia in a boy with thalassemia. Can J Anesth.2005; 52:1002-3. https://doi.org/10.1007/BF03022075

Starodub ME, Trevors JT. Silver accumulation and resistance in E. coli. J Inorganic Biochem.1990; 39(4):3017-25. https://doi.org/10.1016/0162-0134(90)80030-2

Gupta A, Maynes M, Silver S. Effects of halides on plasmid-mediated silver resistance in Escherichia coli. Appl Environ Micro.1998; 64(12):5042-45. https://doi.org/10.1128/AEM.64.12.5042-5045.1998

Lansdown A B G, Sampson B, et al. Silver aids healing in the sterile skin wound: experimental studies in the laboratory rat. Br J Dermatol.1997; 137:728-35. https://doi.org/10.1111/j.1365-2133.1997.tb01109.x

Demling RH, DeSanti L. The role of silver in wound healing. Part 1: Effects of Silver on Wound Management. Wounds. 2001; 13(1):A3-A15.

Kirsner RS, Orsted H, Wright JB (2002) Matrix metalloproteinases in normal and impaired wound healing. A potential role of nanocrystalline silver. Wounds; 2002; 13(3):C5-12.

Bult A, Klasen HB. Archiv der Pharmazie(Weinheim).1980;313:1016. https://doi.org/10.1002/ardp.19803131208

Nesbitt R.U, Sandmann BJ. Journal of Pharmaceutical Sciences.1977; 66:519. https://doi.org/10.1002/jps.2600660414

Boelema GJ, Bult A, Metting HJ, Bajema BL, Doornbos DA. Pharm. Weekblad Scientific edition.1982; 4(38). https://doi.org/10.1007/BF01963659

Khan M.Q, Kharaghani D, Shahzad A, Saito Y, Yamamoto T, Ogasawara H, et al. Fabrication of antibacterial electrospun cellulose acetate/silver-sulfadiazine nanofibers composites for wound dressings applications. Polym. Test. 2019; 74:39-44. https://doi.org/10.1016/j.polymertesting.2018.12.015

Hangyi Lu, Wang Q, et al. Electrospun water-stable zein/ethyl cellulose composite nanofiber and its drug release properties. Mater. Sci. Eng. C. 2017; 74:86-93. https://doi.org/10.1016/j.msec.2017.02.004

Li H, Zhang Z, Godakanda V.U, Patel K, et al.The effect of collection substrate on electrospun ciprofloxacin-loaded poly(vinylpyrrolidone) and ethyl cellulose nanofibers as potential wound dressing materials. Mater Biol Appl. 2019 Nov; 104:109917. https://doi.org/10.1016/j.msec.2019.109917

Godakanda V.U, Li H, Alquezar L, Zhao L, et al. Tunable drug release from blend poly (vinyl pyrrolidone)-ethyl cellulose nanofibers.Int. J. Pharm. 2019; 562:172-179. https://doi.org/10.1016/j.ijpharm.2019.03.035

Malakinezhad H, Kalaee M, Abdouss M, et al.Fabrication and characterization of biodegradable pHResponsive halloysite poly(lactic-co-glycolic acid)micro-sphere for controlled released of phenytoin sodium. J Inorg Organomet Polym Mater 2020; 30:722-730. https://doi.org/10.1007/s10904-019-01263-4

Starodub ME, Trevors JT. Silver accumulation and resistance in E.coli.The Journal of Biochemistry.1990; 39(4):3017-25 https://doi.org/10.1016/0162-0134(90)80030-2

Ali I.H, Khalil I.A, El-Sherbiny I.M. Collagen nanofiber containing silver nanoparticles for improved wound-healing applications. ACS Appl. Mater. Interfaces.2016; 8:14453-14469. https://doi.org/10.1021/acsami.6b04369

Nezhad-Mokhtari P, Ghorbani M, Roshangar L, Soleimani Rad J. Chemical gelling of hydrogels-based biological macromolecules for tissue engineering: photo- and enzymatic-crosslinking methods. Int. J. Biol. Macromol.2019; 139:760-772. https://doi.org/10.1016/j.ijbiomac.2019.08.047

Aghaei A, Soori H, Mehrabi Y, Ramezankhani A. Factors related to pediatric unintentional burns: the comparison of logistic regression and data mining algorithms J Burn Care Res 2019; 40(5):606-612. https://doi.org/10.1093/jbcr/irz066

Hosseini SM, Fekrazad R, Malekzadeh H, Farzadinia P, Hajiani M. Evaluation and comparison of the effect of honey, milk, and combination of honey-milk on experimental induced second-degree burns of Rabit. J Family Med Prim Care. 2020; 9(2):915-920. https://doi.org/10.4103/jfmpc.jfmpc_801_19

Aghaei A, Soori H, Mehrabi Y, Ramezankhani A. Factors related to pediatric unintentional burns: the comparison of logistic regression and data mining algorithms. J Inj Violence Res. 2019; 11(4 Suppl. 2):35.

Castellano JJ, Shafii SM, Ko F, et al. Comparative evaluation of silver-containing antimicrobial dressings and drugs. Int Wound J 2007; 4:114-22. https://doi.org/10.1111/j.1742-481X.2007.00316.x

31. Glat P.M, MD, Kubat W.D, Glat DO, et al. Randomized Clinical Study of SilvaSorb® Gel in Comparison to Silvadene® Silver Sulfadiazine Cream in the Management of Partial-Thickness Burns.Journal of Burn Care.2009; Mar; 30(2):262-7. https://doi.org/10.1097/BCR.0b013e318198a2e8

Duhn LJ, Medves JM. A systematic integrative review of infant pain assessment tools. Adva Neonatal Care. 2004; 4:126-40. https://doi.org/10.1016/j.adnc.2004.04.005

Akbari H, Fatemi MJ, Iranpour M, et al. The healing effect of nettle extracts on second degree burn wounds. World J Plast Surg. 2015; 4:23-8.

Mohseni, M., et al., Antimicrobial wound dressing containing silver sulfadiazine with high biocompatibility: in vitro study. Artificial organs. 2016; 40(8):765-773. https://doi.org/10.1111/aor.12682

Shamloo A, Sarmadi M, et al, Accelerated full-thickness wound healing via sustained bFGF delivery based on a PVA/chitosan/gelatin hydrogel incorporating PCL microspheres. 2018; 537(1-2):278-289. https://doi.org/10.1016/j.ijpharm.2017.12.045

Rasha AA, Rasha EE and Galal HE: Design and synthesis of a new class of pyridine-based n-sulfonamides exhibiting antiviral, antimicrobial, and enzyme inhibition characteristics. CS Omega 2020; 5(18):10401-414

Published

15-07-2022
Statistics
Abstract Display: 939
PDF Downloads: 639
PDF Downloads: 1083

How to Cite

1.
Walia SS, Prasad D. Silver Sulfadiazine: Action on Burn Wound Sepsis and Infections. J. Drug Delivery Ther. [Internet]. 2022 Jul. 15 [cited 2025 Jul. 8];12(4):154-61. Available from: https://jddtonline.info/index.php/jddt/article/view/5419

How to Cite

1.
Walia SS, Prasad D. Silver Sulfadiazine: Action on Burn Wound Sepsis and Infections. J. Drug Delivery Ther. [Internet]. 2022 Jul. 15 [cited 2025 Jul. 8];12(4):154-61. Available from: https://jddtonline.info/index.php/jddt/article/view/5419

Most read articles by the same author(s)

> >>