Herbal Drugs with Anti-Diabetic Potential

  • Smily Walia Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India
  • J.S. Dua Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India
  • D.N. Prasad Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Punjab, India

Abstract

Diabetes mellitus (DM), also known as insulin-dependent diabetes mellitus (IDDM) and non-insulin dependent diabetes mellitus (NIDDM), is a common and serious metabolic condition that affects people all over the world. Traditional herbal plants have been utilized to treat diabetes mellitus all throughout the world. Several herbs have been found to treat and control diabetes among numerous medicines and poly herbal plants; they also have no adverse effects. Diabetes mellitus is a horrible disease that affects people all over the world and is becoming a serious danger to humanity's health.  Thus, herbal plants may be a possible source of anti-diabetic medicines, with ethno botanical data indicating that around 800 plants may have anti-diabetic potential. Although synthetic oral hypoglycemic agents/insulin are a popular diabetes therapy and are effective in controlling hyperglycemia, they have significant side effects and do not significantly modify the course of diabetic complications. This is the primary reason why an increasing number of individuals are looking for alternative medicines with fewer or no adverse effects. The botanical name, common name, component, and mechanism of action for anti-diabetic activity were provided in this review study, as well as plant-based commercial poly herbal formulations.


Keywords: Diabetes mellitus, Medicinal plants, glucose, poly herbal plants

Keywords: Diabetes mellitus, Medicinal plants, glucose, poly herbal plants

Downloads

Download data is not yet available.

Author Biographies

Smily Walia, Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

J.S. Dua, Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

D.N. Prasad, Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Punjab, India

Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Punjab, India

References

1. Joseph B, Jini D. An insight in hypoglycemic effect of traditional Indian herbs used in the treatment of diabetes, Research Journal of Medicinal plant. 2011; 5:352-376. https://doi.org/10.3923/rjmp.2011.352.376
2. Tanaka K, Nishizono S, Makino N, Tamaru S, Terai O, Ikeda I. Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice.Biosci Biotechnology Biochem 2008, 72:686-693. https://doi.org/10.1271/bbb.70411
3. C.K .Kokate, A.P .Purohit Pharmacognosy, Published By Nirali Prakashan, Vol 1&2, 47th Edition, 2008.
4. Deb L, Dutta A. Diabetes mellitus its possible pharmacological evaluation techniques and naturopathy. Int J Green Pharmacy 2006; 1:7-28.
5. Murray, M.T.: (1995). Healing power of Herbs. 2nd edition, Gramercy Books NY, pp: 357.
6. Grover J K, Yadav S, Vats V, Medicinal plants of India with anti-diabetic potential, J Ethnopharmacol , 200281:81. https://doi.org/10.1016/S0378-8741(02)00059-4
7. Shukla R, Sharma S B, Puri D, Prabhu K M & Murthy P S , Medicinal plants for treatment of diabetes mellitus, Indian Journal of Clinical Biochemistry, 2000; 15(Suppl.):169. https://doi.org/10.1007/BF02867556
8. Mutalik S, Sulochana B, Chetana M, Udupa N, Uma Devi UP. Preliminary studies on acute and sub acute toxicity of an anti diabetic herbal preparation, Dianex. Indian Journal of Experimental Biology. 2003; 4:316- 320.
9. Piyush MP, Natvarlal MP, Ramesh KG. Holistic classification of herbal antidiabetics: A review. Pharma Times, 2006; 38:19-25.
10. Sharma R, Arya V. A Review on Fruits Having Anti-Diabetic Potential. Journal of Chemical and Pharmaceutical Research. 2011; 3(2):204-212.
11. Rao MU, Sreenivasulu M, Chengaiah B, Reddy KJ, Chetty CM. Herbal Medicines for Diabetes Mellitus: A Review. International Journal of PharmTech Research. July-Sept 2010; 2(3):1883-1892.
12. Dahanukar SA, Kulkarni RA, Rege NN. Pharmacology of Medicinal Plants and Natural Products (1994- 98), Indian J Pharmacol. 2000; 32:S81-S118.
13. Edwin Jarald, Siddaheswar Balakrishnan Joshi and Dharam Chandra Jain. Diabetes and Herbal Medicines. Iranian Journal of Pharmacology and Therapeutics, 2008; 7:97-106.
14. Dahanukar SA, Kulkarni RA, Rege NN. Pharmacology of Medicinal Plants and Natural Products (1994- 98),Indian J Pharmacol. 2000; 32:S81-S118.
15. Pulok KM, Kuntal M, Kakali M, Peter JH. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol 2006; 106:1-28. https://doi.org/10.1016/j.jep.2006.03.021
16. Pritesh Patel, Pinal Harde, Jagath Pillai, Nilesh Darji and Bhagirath Patel Sat Kaival Pharmacophore 2012; 3:18-29.
17. Eddouks M, Maghrani M. Phlorizin-like effect of Fraxinus excelsior in normal and diabetic rats. JEthnopharmacol 2004; 9:149-54. https://doi.org/10.1016/j.jep.2004.05.005
18. Mohamed B, Abderrahim Z, Hassane M, Abdelhafid T, Abdelkhaleq L. Medicinal plants with potential anti diabetic activity-A review of ten years of herbal medicine research (1990-2000). Int J Diabetes Metabol 2006; 14:1-25. https://doi.org/10.1159/000497588
19. Manisha Modak, Priyanjali Dixit, Jayant Londhe, Saroj Ghaskadbi, and Thomas Paul A. Indian Herbs and Herbal Drugs Used for the Treatment of Diabetes., J. Clin. Biochem. Nutr.2007; 40:163-173. https://doi.org/10.3164/jcbn.40.163
20. Ghosh MN. Fundamentals of experimental Pharmacology. 3rd ed. Hilton and Company; 2005. P. 190 - 7. 21. Dwivedi Chandraprakash, Daspaul Swarnali, Antidiabetic Herbal Drugs and Poly herbal Formulation Used For Diabetes: A Review, The Journal of Phytopharmacology 2013; 2 (3):1-7
22. Wadood, A., N. Wadood and S.A. Shah, 1989. Effects of Acacia Arabica and Caralluma edulis on blood glucose levels of normal and alloxan diabetic rabbits. JPMA. The Journal of Pakistan Medical rabbits. JPMA. The Journal of Pakistan Medical Association, 39(8):208-12.
23. Mukesh Rawat, Namita Parmar, Medicinal Plants with Antidiabetic Potential - A Review, American Eurasian J. Agric. & Environ. Sci., 13 (1):81-94, 2013.
24. Akhtar, M.S. and J. Iqbal,. Evaluation of the hypoglycemic effect of Achyranthes aspera in normal and alloxan-diabetic rabbits J. Ethnopharmacol., 1991; 31:49-57. https://doi.org/10.1016/0378-8741(91)90143-2
25. Kumari, K., B.C. Mathew and K.T. Augusti. Antidiabetic and hypoHpidaemic effects of S-methyl cysteinesulfoxide, isolated from Allium cepa Linn. Ind. J. Biochem. Biophys, 1995; 32:49-54.
26. Gupta, D., J. Raju, N.Z. Baquer, Modulation of some gluconeogenic enzyme activities in diabetic rat liver and kidney: effect of anti diabetic compounds. Indian J. Expt. Biol., 1999; 37:196-99.
27. Kirtikar KR, Basu BD. Indian Medicinal Plants, Indian Press, Allahabad, India, 1933: 1052-1054.
28. Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Am J Clin Nutr 2007; 85:1552-1556? https://doi.org/10.1093/ajcn/85.6.1552
29. Dey L, Attele AS, Yuan C. Alternative therapies for Type 2 Diabetes Review. Alternative Medicine Review.2002; 7(1):45-58.
30. Roman-Ramos, R., J.L. Flores-Saenz and F.J. Alarcon-Aguilar. Antihyperglycemic effect of some edible plants. J. Ethnopharmacol., 1995; 48:25-32 https://doi.org/10.1016/0378-8741(95)01279-M
31. Gupta, D., J. Raju, N.Z. Baquer. Modulation of some gluconeogenic enzyme activities in diabetic rat liver and kidney: effect of anti diabetic compounds Indian J. Expt. Biol., 1999; 37:196-99.
32. Zacharias, N.T., K.L. Sebastian, B. Philip and K.T. Augusti. Hypoglycemic and hypolipidemic effects of garlic in sucrose fed rabbits. Indian Journal of Physiology and Pharmacology, 1980; 24:151-54.
33. Ajabnoor, M.A.. Effect of aloes on blood glucose levels in normal and alloxan diabetic mice. J. Ethnopharmacol., 1990; 28:215-20. https://doi.org/10.1016/0378-8741(90)90031-N
34. Ghannam, N., M. Kingston, I.A. Al-Meshaal, M. Tariq, N.S. Parman and N. Woodhouse. M. Tariq, N.S. Parman and N. Woodhouse, 1986. and experimental observations. Hormone Research, 1986; 24:288-94. https://doi.org/10.1159/000180569
35. Noor A, Gunasekaran S, Soosai A, Minicab, Vijayalakshmi MA. Antidiabetic activity of Aloe Vera and histology of organs in streptozotocin induced diabetic rats. Current science 2008; 94:1070-1076.
36. Rehman SU, Jafri SA, Hassan S, Ishtiaq N, Muhammad N. Study on anti-diabetic effect of Aloe Vera extract on alloxan induced diabetic rats. Libyan Agriculture Research Center Journal International 2011; 2:29-32.
37. Zhang, X.F. and Tan, B.K. Anti hyperglycemic and antioxidant properties of Andrographis paniculata in normal and diabetic rats. Clin. Exp. Pharm. Phy., 2000b; 27:358-363. https://doi.org/10.1046/j.1440-1681.2000.03253.x
38. Yu, B.C., Hung, C.R., Chen, W.C. and Cheng, J.T. Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta Med., 2003; 69:1075-1079. https://doi.org/10.1055/s-2003-45185
39. Teonard, L., T. Dimo and D. Paul,. Antihyperglycemic and renal protective activities of Anacardium occidentale (anacardiaceae) leaves in streptozotocin induced diabetic rats Afr. J. Tradit. Complement. Altern. Med., 2006; 3(1):23-25. https://doi.org/10.4314/ajtcam.v3i1.31136
40. Mohd M, Alam K S, Mohd A, Abhishek M, & Aftab A, Antidiabetic activity of the aqueous extract of Annona squamosa in Streptozotocin induced hyperglycemic rats, T. Pharm. Res, 2009; 2:59.
41. Waheed, A., G.A. Miana and S.I. Ahmad, Clinical investigation of hypoglycemic effect of seeds of Azadirachta-inidca in type-2(NIDDM) diabetes mellitus. Pak. J. Pharm. Sci., 2006; 19:322-25.
42. Sokeng, S.D., B. Rokeya and M. Mostafa, Antihyperglycemic effect of Bridelia ndellensis ethanol extract and fractions in Streptozotocin-induced diabetic Rats Afr. J. Tradit. Complement. Altern. Med., 2005; 2:94. https://doi.org/10.4314/ajtcam.v2i2.31107
43. Singh S.N., Vats P., Suri S., et al.: J. Ethnopharmacol. 2001; 76:269 https://doi.org/10.1016/S0378-8741(01)00254-9
44. Rasineni K, Bellamkonda R, Singareddy S R, Desireddy S, Antihyperglycemic activity of Catharanthus roseus leaf powder in streptozotocin-induced diabetic rats, Phcog. Res, 2010; 2:195 https://doi.org/10.4103/0974-8490.65523
45. Uebanso, T., H. Arai, Y. Taketani, M. Fukaya, H. Yamamoto, A. Mizuno, K. Uryu and T. Hada. H. Yamamoto, A. Mizuno, K. Uryu and T. Hada, 2007. postprandial hyperglycemia in rats. Nutr. Sci, Vitaminol. (Tokyo), 2007; 53:482-88. https://doi.org/10.3177/jnsv.53.482
46. Vitaminol. (Tokyo), Improvement of insulin resistance by panax ginseng in fructose-rich chowfed rats. Horm. Metab Res., 37: 146-51. https://doi.org/10.1055/s-2005-861299
47. Panax ginseng Monograph. Alternative Medicine Review. 2009; 14(2):172-176.
48. Mishra R, Shuaib M, Shravan, Mishra PS. A review on herbal antidiabetic drugs. Journal of Applied Pharmaceutical Science. 2011; 1(6):235-237.
49. Tripathi AK, Bhoyar PK, Baheti JR, Biyani DM, Khalique M, Kothmire MS, et al. Herbal Antidiabetics: A Review. International Journal of Research in Pharmaceutical Sciences.2011; 2(1):30-37.
50. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential.
51. Romila Y, Mazumder PB, Choudhary MD. A Review on Ant diabetic Plants used by the People of Manipur Charactirized by Hypoglycemic Activity. Assam University Journal of Science & Technology: Biological and Environmental Sciences. 2010; 6(1):167-175.
52. Kumar AS, Kavimani S, Jayaveera KN. A review on medicinal Plants with potential antidiabetic activity. International Journal of Phytopharmacology. 2011; 2(2):53-60.
53. Grover JK, Yadav S, Vats V, Medicinal plants of India with anti-diabetic potential, Journal of Ethnopharmacology. 2002; 81:81-100 https://doi.org/10.1016/S0378-8741(02)00059-4
54. Martinez, G., R. Delgado, G. Perez, G. Garrido Nunez A.J. Selles and O.S. Leon. Evaluation of the in vitro antioxidant activity of Mangifera indica L. extract. Phytotherapy Research, 2000; 14(6):424-27. https://doi.org/10.1002/1099-1573(200009)14:6<424::AID-PTR643>3.0.CO;2-8
55. Chandraprakash et al, indian herbal medicines used for treatment of dementia: an overview, world journal of pharmaceutical research, volume 3, issue 6, 344-382.
56. Rai PK, Jaiswal D, Mehta S, Watal G, Anti-hyperglycaemic potential of Psidium guajava raw fruit peel. Indian J Med Res. 2009; 129: 561-565.
57. Velmurugan C, Sundaram T, Sampath Kumar R, Vivek B, Sheshadri Sekar D & Ashok kumar B S, Anti Diabetic and Hypolipidemic Activity of Bark of Ethanolic Extract of Ougeinia Oojeinensis (ROXB.), Med J Malaysia, 2011; 66:22.
58. Seema P V, Sudha B, Padayatti S P, Abraham A, Raghu K G & Paulose C S, Kinetic studies of purified malate dehydrogenase in liver of streptozotocin-diabetic rats and the effect of leaf extract of Aegle marmelos (L.) Corr, Indian J Exp Biol, 1996; 34:600.
59. Poongothai K, Ponmurugan P, Ahmed K S Z, Kumar S B & Sheriff S A, Antihyperglycemic and antioxidant effects of Solanum xanthocarpum leaves (field grown & in vitro raised) extracts on alloxan induced diabetic rats, Asian Pac. J. Trop. Med, 2011; 4:778. https://doi.org/10.1016/S1995-7645(11)60193-4
60. Arumugam sathy, Perumal Siddhuraju, Protetive effect of bark and empty pod extracts from acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes, Food and tocicology, 2013; 56:162-170. https://doi.org/10.1016/j.fct.2013.02.031
61. B,S,Ashok Kumar, Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of amaranthus viridis Linn in alloxan induced diabetic rats, Experimental and toxicologic pathology, 2012; 64:75-779. https://doi.org/10.1016/j.etp.2010.06.009
62. Patil RN, Patil RY, Ahirwar A, Ahirwar D, Evaluation of antidiabetic and related actions of some Indian medicinal plants in diabetic rats, Asian Pac J Trop Med, 2011; 4:20-23. https://doi.org/10.1016/S1995-7645(11)60025-4
63. Ayodhya S, Kusum S, Anjali S, Hypoglycemic activity of different extracts of various herbal plants Singh, Int J Ayurveda Res Pharm, 2010; 1(1):212-224.
64. Bnouham M, Ziyyat A, Mekhfi H, Tahri A, Legsyer A, Medicinal plants with potential antidiabetic activity- a review of ten years of herbal medicine research, (1990-2000), Int J Diabetes metab, 2006; 14:125. https://doi.org/10.1159/000497588
65. K shirsagar RP, Darade SS, Takale V, Effect of Alangium salvifolium (Alangiaceae) on dexamethasone induced insulin resistance in rats, J Pharm Res, 2010; 3(11):271-276.
66. Chauhan A, Sharma PK, Srinivastava P, Kumar N, Duehe R, Plants having potential antidiabetic activity, A review, Der pharm let, 2010; 2(3):369-387.
67. Singh LW, Traditional medicinal plants of Manipur as antidiabetics, J Med Plant Res, 2011; 5(5):677-687.
68. Malviya N, Jain S, Malviya S, Antidiabetic potential of medicinal plants, Acta Pol Pharm, 2010; 67(2):113-118.
69. Park S, Jang JS, Hong SM, Long - term consumption of caffeine improves glucose homeostasis by enhancing insulinotropic action through islet insulin/insulin - like growth factor 1 signaling in diabetic rats, Metabolism, 2007; 29(1):599-607. https://doi.org/10.1016/j.metabol.2006.12.004
70. Islam MS, Choi H, Green tea, anti- diabetic or diabetogenic, a dose response study, Biofactors, 29(1), 2007, 45-53. https://doi.org/10.1002/biof.5520290105
71. Islam S, Choi H, Dietary red chilli (Capsicum frutescns L) is insulinotropic rather than hypoglycemic in type 2 diabetes model of rats, Phytother Res, 2008; 22(8):1025-1029. https://doi.org/10.1002/ptr.2417
72. Dallak M, Al- khateeb M, abbas M, Elessa R, al- hashem F, basher N, Et al, In vivo, acute, normo - hypoglycemic, antihyperglycemic, insulinotropic actions of orally administered ethanol extract of citrullus colocynthis(L) Scharb pulp, Am J BIochem BIotechnol, 2009; 5(3):119-126. https://doi.org/10.3844/ajbbsp.2009.119.126
Statistics
70 Views | 2 Downloads
How to Cite
1.
Walia S, Dua J, Prasad D. Herbal Drugs with Anti-Diabetic Potential. JDDT [Internet]. 15Nov.2021 [cited 1Dec.2021];11(6):248-56. Available from: https://jddtonline.info/index.php/jddt/article/view/5051