In-Situ Ocular Gel Pharmaceutical Delivery System: A Recent Review
Abstract
Ocular Drug Delivery has been a key challenge and attractive field for the pharmaceutical scientist due to peerless anatomy and physiology of eye. Glaucoma, dry eye syndrome, keratitis, endophthalmitis, trachoma, and conjunctivitis are just a few of the conditions that can affect the eye. In order to accomplish efficient ocular treatment within the eye, At the point of action, an appropriate supply of active substances must be given and sustained. Due to fast precorneal medication loss, traditional treatment has a low bioavailability. The bioavailability of a medicine is also influenced by static and dynamic barriers. To address the limitations of traditional treatment, significant efforts are being made to develop innovative medication systems for ocular delivery. When a drop is injected into the eye, it goes through a sol-gel transition and forms a cul-de-sac. The in-situ gel system, which comprises thermally triggered, pH triggered, and ion cross linking systems, is the subject of this review. It includes a step-by-step procedure for preparing the pH-triggered system as well as assessment parameters.
Keywords: Conventional dosage form, Anatomy and physiology in eye, In-situ gel.
Keywords:
Conventional dosage form, Anatomy and physiology in eye, In-situ geLDOI
https://doi.org/10.22270/jddt.v11i6-S.5098References
EL-Kamel AH. In vitro and in vivo evaluation of Pluronic F127- based ocular delivery system for timolol maleate. International journal of pharmaceutics 2002; 24 (1):47-55. https://doi.org/10.1016/S0378-5173(02)00234-X
Varshosaz J, Tabbakhian M, Salmani Z. Designing of a Thermo sensitive Chitosan/Poloxamer In Situ Gel for Ocular Delivery of Ciprofloxacin. The Open Drug Delivery Journal 2008; 2:61-70. https://doi.org/10.2174/1874126600802010061
Nalla A and Chinnala K M. In - situ ophthalmic drug delivery systems - An Overview, Indo Am. J. Pharm. Sci. 2016; 3(3): 202-208.
Peppas NA, Langer R. New challenges in biomaterials. Science 1994; 263(5154):1715-1720. https://doi.org/10.1126/science.8134835
Swapnil S. A review on polymers used in novel in situ gel formulation for ocular drug delivery and their evaluation. Journal of biological and scientific opinion 2003; 1(2):132-137. https://doi.org/10.7897/2321-6328.01221
Mishima, S., Gasset, A., Klyce, S.D., Baum, J.L. Determination of tear volume and tear flow. Invest. Ophthalmol1966; 5:264-276.
Watzke M.A., Jablonski M.M., Edelhauser H.F. Comparison of conjunctiva and corneal surface areas in rabbits and human. Curr. Eye Res.1988; 7:483-486. https://doi.org/10.3109/02713688809031801
Lee V.H.-L., Robinson J.R. Mechanistic and quantitative evaluation of precorneal pilocarpine disposition in albino rabbits. J. Pharm. Sci.1979; 68:673-684. https://doi.org/10.1002/jps.2600680606
Desai S.D., Blanchard J., Swarbick J., Boylan J.C. (Ed.), Ocular drug formulation and delivery. Encyclopedia of Pharmaceutical Technology, Marcel Dekker, New York, 1944; 11:43-75.
Chrai S.S., Patton T.F., Mehta A., Robinson J.R., 1973. Lacrimal and instilled fluid dynamics in rabbit eyes. J. Pharm. Sci.1973; 62:1112-1121. https://doi.org/10.1002/jps.2600620712
Yumei WU et al., Research Progress of in-situ gelling Ophthalmic Drug Delivery System, Asian Journal of Pharmaceutical Science, 2018; 22-40.
Hajare A, Mali S, Salunke S, Nadaf S, Bhatia N, Bagal P, Gaikwad S, Pawar K, A Rational Approach to Ocular Drug Delivery System: An Overview, World Journal of Pharmaceutical Science, 2014; 3(2):3324-3348.
Yerikala R, Kothapalli CB, Peddappi Reddigari JR, A Novel Approach on Ophthalmic Drug Delivery System, Journal of Drug Delivery and Therapeutics, 2017; 7(6):117-124. https://doi.org/10.22270/jddt.v7i6.1512
Pandya TP, Modasiya MK, Patel VM, Ophthalmic In-Situ Gelling System, International Journal of Pharmacy and Life Sciences, 2011; 2(5): 730-738.
Jain S, Jain P, Mishra M, Pathak A, A Review on Triggered Gel for Ocular Drug Delivery System, International Journal of Pharmaceutical and Biological Archieves, 2014; 5(4):19-24.
Palani S, Joseph NM, Goda CC, Zachariah A, Ayenew Z, Ocular Drug Delivery: A Review, International Journal Pharmaceutical Science and Research, 2010; 1(3):1-11.
Short BG. Safety evaluation of ocular drug delivery formulation: techniques and practical considerations. Toxicologic pathology, 2008; 36:49-62. https://doi.org/10.1177/0192623307310955
Saini N, Kumar D, An Insight to Ophthalmic Drug Delivery System, International Journal of Pharmaceutical Studies and Research 2012; 3(2):09-13.
Pandey H, Sharma UK and Pandey AC. Eudragit- based nanostructures: A potential approach for ocular drug delivery. Int J Res Dev Pharm L Sci, 2012; 1(2):40-3.
Tangri P, and Khurana S. basics of ocular drug delivery systems. Int J Res Pharm and Biomed Sci 2011; 2(4):1541-1552.
Haders DJ. New controlled release technologies broaden opportunities for ophthalmic therapies. Drug delivery technology, 2008; 8(7):48-53.
Patel Nisha, Shinde Gajanan, and KS Rajesh. Ophthalmic In situ gel, A genesis journal Pharmagene 2014; 2(4):29-33.
Suisha F, Kawasaki N, Miyazaki S, Shirakawa M, Yamatoya K, Sasaki M, Attwood D, Xyloglucan gels as sustained-release vehicles for the intraperitoneal administration of mitomycin C. Int. J. Pharm., 1998; 172:27- 32. https://doi.org/10.1016/S0378-5173(98)00157-4
Miyazaki S, Endo K, Kawasaki N, Kubo W, Watanabe H, Attwood D. Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations. Drug Dev Ind. Pharm. 2003; 29(2):113-9. https://doi.org/10.1081/DDC-120016718
Nerkar Tushar, Gujarathi Nayan A, Rane Bhushan R, Bakliwal Sunil R, Pawar S.P. In situ gel: Novel Approach in a sustained and controlled drug delivery system. International Journal of Pharmaceutical Sciences 2013; 4(4):1-18.
Saraswat R.1, Bhan C. S., Gaur A. A Review on Polymers Used in In-Situ Gel Drug Delivery Systems 2011; 1(2).
Zhidong L, Jaiwei L, Shufang N, Study of a Pharma alginate- HPMC based in situ gelling ophthalmic delivery system for gatifloxacin. Int J., 2016; 315:12- 7.
Khan N, AqilM, ImamSS, Ali A. Development and evaluation of a novel in situ gel of sparfloxacin for sustained ocular drug delivery: in vitro and ex vivo characterization. Pharm Dev Technol 2015; 20(6):662-9 https://doi.org/10.3109/10837450.2014.910807
Li J, ZhaoH, OkekeCI, etal. Comparison of systemic absorption between ofloxacin ophthalmic in situ gels and ofloxacin conventional ophthalmic solutions administration to rabbit eyes by HPLC-MS/MS. Int J Pharm 2013; 450(1-2):104-13. https://doi.org/10.1016/j.ijpharm.2013.04.018
Devasani SR, DevA, RathodS, DeshmukhG. An overview of in situ gelling systems. Pharmaceut Biolog Evaluat 2016; 3(1):60-9.
Srividya B, Cardoza R. M., Amin P.D. Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling systems. J. Control Release. 2001; 73:205-211. https://doi.org/10.1016/S0168-3659(01)00279-6
Wen-Di Ma, Hui Xu, Chao Wang, Shu-Fang Nie, Wei-San Pan, Pluronic F127-g-poly (acrylic acid) copolymers as in situ gelling vehicles for ophthalmic drug delivery system, int. j. of pharmaceutics, 2008; (350):247-256. https://doi.org/10.1016/j.ijpharm.2007.09.005
Vodithala Sirish, Khatry Sadhana, Shastri Nalini, Sadanandam M, Formulation and evaluation of ion activated ocular gels of ketorolac tromethamine International Journal of Current Pharmaceutical Research, 2010 ;2(3).
M. Jothi, Harikumar SL and Aggarwal Geeta, In-situ ophthalmic gels for the treatment of eye diseases, International Journal of Pharmaceutical Sciences and Research, 2012; 3:1891-1904.
Rajas NJ, Kavitha K, Gounder T, Mani T, In-Situ ophthalmic gels a developing trend, Int J Pharm Sci Rev and Res, 2011; 7:8-14.
Geraghaty P, Attwood D, et al. An investigation of parameters influencing the Bioadhesive properties of Myverol 18-99/ water gels. Biomaterials 1997; 18:63-7. https://doi.org/10.1016/S0142-9612(96)00087-7
Devasani SR, DevA, RathodS, Deshmukh G. An overview of in situ gelling systems. Pharmaceut Biolog Evaluat 2016; 3(1):60-9.
Laddha UD, Mahajan HS. An insight to ocular in situ gelling systems. Int J Adv Pharmaceut 2017; 06(02):31-40.
Klouda L. Thermoresponsive hydrogels in biomedical applications: a seven-year update. Eur J Pharm Biopharm 2015;97(Pt B):338-49. https://doi.org/10.1016/j.ejpb.2015.05.017
Zambito Y, Colo GD. Polysaccharides as excipients for ocular topical formulations. Polysaccharides as excipients for ocular topical formulations. InTech; 2011. p. 253-80. https://doi.org/10.5772/24430
Mohammed S, Chouhan G, Anuforom O, et al. Thermosensitive hydrogel as an in situ gelling antimicrobial ocular dressing. Mater Sci Eng C Mater Biol Appl 2017; 78:203-9. https://doi.org/10.1016/j.msec.2017.04.065
Sandeep DS, Charyulu NR, Narayanan AV, Smart in Situ Gels for Glaucoma-An Overview, International Journal of Pharmaceutical Science Research and Review, 2018; 50(1):94-100.
Majeed A., Khan N. A. Ocular in situ gel: An overview. Journal of Drug Delivery and Therapeutics, 2019; 9(1):337-347. https://doi.org/10.22270/jddt.v9i1.2231
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