Development and Evaluation of Gastro Retentive Floating Drug Delivery System of Ondansetron Hydrochloride

  • Abadhesh Kumar Niranjan Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Ghaila road, Gazipur Balram, Lucknow-226020, Uttar Pradesh, India https://orcid.org/0000-0002-2407-6902
  • Aditya Kumar Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Ghaila road, Gazipur Balram, Lucknow-226020, Uttar Pradesh, India

Abstract

The Aim of the present study was to develop & evaluate Gastro-retentive floating Tablet of Ondansetron hydrochloride. The Objective was to calibrate and validate the UV- spectroscopy analytical method and to prepare and optimize the GR Floating tablets of Ondansetron hydrochloride in terms of dissolution release profile. The FDDS of the drug can minimize the fluctuation of drug plasma levels and result to associated adverse reactions, dosing frequency, and improved patient compliance. Conventionally, Ondansetron hydrochloride is taken up 2-3 times daily in the treatment of nausea and vomiting. Gastro retentive floating tablet of Ondansetron hydrochloride is better suited for treatment of postoperative nausea vomiting. In the present study, nine Gastro retentive Floating tablet formulations (F1, F2.....F9) of Ondansetron hydrochloride were prepared by the  method of direct compression and polymers HPMC K15 were used and Guargum and Chitosan, in different quantity to normalise their effect on the’ release profile of drug . Target release profile was >80% release of drug in 12 hours. Tablets were evaluated for various parameters namely: thickness, weight variation’, friability, hardness, assay, in-vitro buoyancy study & drug release. Formulation F8 containing Chitosan (26.66% w/w), Guargum (26.66% w/w) and Sod. Carbonate (25.83% w/w) had the desirable release profile.


Keywords: Ondansetron hydrochloride; Gastro retentive floating tablet, Chitosan, Guar gum, Drug release

Keywords: Ondansetron hydrochloride, Gastro retentive floating tablet, Chitosan, Guar gum, Drug release

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Author Biographies

Abadhesh Kumar Niranjan, Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Ghaila road, Gazipur Balram, Lucknow-226020, Uttar Pradesh, India

Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Ghaila road, Gazipur Balram, Lucknow-226020, Uttar Pradesh, India

Aditya Kumar, Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Ghaila road, Gazipur Balram, Lucknow-226020, Uttar Pradesh, India

Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Ghaila road, Gazipur Balram, Lucknow-226020, Uttar Pradesh, India

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Niranjan AK, Kumar A. Development and Evaluation of Gastro Retentive Floating Drug Delivery System of Ondansetron Hydrochloride. JDDT [Internet]. 21Nov.2021 [cited 1Dec.2021];11(6):150-8. Available from: https://jddtonline.info/index.php/jddt/article/view/5084