Floating Microsponge: An Emerging Drug Delivery System
Abstract
Floating microsponges are a method to extend gastric residence time, there with the aid of using concentrated on site-responsive medicament liberate withinside the top GIT for locally or systemic effect. Gastro retentive dosage forms (GRDFs) are getting utilized from a totally long term to enhance treatment with numerous main medications. Floating microsponge significantly enhances the therapy of stomach with the aid of using liberating the medication locally and for that reason used for medication selecting at specific organ. This may be sustained over an extended period of time. Floating drug delivery allow extended and non-stop release of the drug to the top a part of Gastro intestinal tract and this expressively amplify the period of drug release and enhance pharmacokinetic of medication which have slim healing window, with the aid of using this method dosing frequency and affected person compliance is increased. A microsponge’s drug delivery system is a particularly cross-linkage, spongy, polymeric microsphere, polymeric device consisting permeable microspheres. Microsponges are prepared with the aid of using numerous techniques consisting of liquid-liquid suspension polymerization and quasi emulsion solvent diffusion method. Microsponge,s preparations are strong over variety of pH 1 to 11; microsponge,s preparations are strong on the temperature as much as 1300C well suited with maximum vehicles and ingredients. The present assessment introduces microsponge,s technology at the side of its techniques of preparation, characterization, advantages, evaluation and release mechanism of microsponge,s drug delivery system, advertised product and up to date studies regarding microsponge.
Keywords: Floating microsponge, Oral administration, Controlled release, Quasi emulsion, Target release.
Keywords:
Floating microsponge, Oral administration, Controlled release, Quasi emulsion, Target releaseDOI
https://doi.org/10.22270/jddt.v12i4-S.5553References
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