The Role of Regenerative Medicine in Wound Healing in Cases of Vesicovaginal Fistulae


Background: Post-surgical wound healing in cases of vesicovaginal fistulae is a challenge because it is related to infection prevention and the long-term well-being of women.

Aim: The aim of this research was to critically review the application of regenerative medicine in wound healing. The next aim was to look in depth to see whether regenerative medicine strategies have a place in the future of wound healing in a clinical setting. More specifically, to see if these strategies would apply for vesico vaginal fistulae case in the field of urogynecology.

Method: A narrative literature review examines several previous research published at the last 5 years, containing keywords, namely vesicovaginal fistulae, regenerative medicine, wound healing. We used databases from Google Scholar, PubMed and Scopus Database.

Results: A vesicovaginal fistula is an abnormal communication between the bladder and the vagina. There are currently no precise guidelines for the postoperative management of patients after fistula repair. Transvaginal surgical procedures are a common solution for vesicovaginal fistulas. In wound healing, more attention is needed because of the risk of infection especially wound healing in the area of ​​​​the reproductive organs. It should also be noted that stress urinary incontinence is a common complication. Several studies have initiated the trial process of regenerative medicine for using in urogynecological cases.

Conclusion: In the management of vesico vaginal fistula cases, regenerative medicine can be a solution in postoperative care but still needs further development and standardization.

Keywords: placenta, urogynecology, regenerative medicine

Keywords: placenta, urogynecology, regenerative medicine


Download data is not yet available.

Author Biographies

Eighty Mardiyan Kurniawati, Division of Urogynecology Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Division of Urogynecology Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Nur Anisah Rahmawati, School of Midwifery, Universitas Airlangga, Surabaya, Indonesia

School of Midwifery, Universitas Airlangga, Surabaya, Indonesia


1. Umeora OUJ, Emma-Echiegu NB. Vesico-Vaginal Fistula in Developing Countries - Time to Turn off The Tap. J Preg Child Health, 2015; 2:e120
2. Ahmed S. El-Azab, Hassan A. Abolella, Mahmoud Farouk. Update on vesicovaginal fistula: A systematic review, Arab Journal of Urology, 2019; 17(1):61-68,
3. Rodjani, A., Sandy, N.J. Prevalence of urogynecology fistula in Cipto Mangunkusumo National Hospital from 2011-2017. IJBS, 2021; 15(1): 48-50
4. Garthwaite M, Harris N. Vesicovaginal fistulae. Indian J Urol, 2010; 26(2):253-256
5. Taher, T. R., Zulfikar, Wahyudi, I., & Rodjani, A. Vesico-Vaginal Fistula: Experience of 11 Years. Indonesian Journal of Urology, 2013
6. Nourian Dehkordi, A., Mirahmadi Babaheydari, F., Chehelgerdi, M. et al. Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies. Stem Cell Res Ther, 2019; 10(111)
7. Calver pang, Amel Ibrahim, Neil Bulstrode, Patrizia Ferretti. An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing: Advances and limitations in regenerative medicine for stimulating wound repair. International Wound Journal, 2017; 14(3)
8. Rajaian S, Pragatheeswarane M, Panda A. Vesicovaginal fistula: Review and recent trends. Indian J Urol, 2019; 35(4):250-258
9. Kumar M, Agarwal S, Goel A, Sharma A, Agarwal A, Pandey S, Sankhwar S, N: Transvaginal Repair of Vesico Vaginal Fistula: A 10-Year Experience with Analysis of Factors Affecting Outcomes. Urol Int, 2019; 103:218-222
10. Christopher J. Hillary, Christoper R. Review The choice of surgical approach in thetreatment of vesico-vaginal fistulae. Chapple Asian Journal of Urology, 2018; 5:155e159
11. Mark P. Lachiewicz, Laura J. Moulton, Oluwatosin Jaiyeoba, "Pelvic Surgical Site Infections in Gynecologic Surgery", Infectious Diseases in Obstetrics and Gynecology, 2015; 614950: 8
12. Cedric Emanuel Boesch, Wolfgang Umek. Effects of Wound Closure on Wound Healing in Gynecologic Surgery A Systematic Literature Review. The Journal of reproductive medicine, 2009; 54(3):139-44
13. Nieuwoudt, A., Appleby, C., & Mukhopadhyay, S. Native Tissue Repair and Principles of Wound Healing: Introducing the Concept of Regenerative Surgery in Vaginal Prolapse Repair. Journal Of Clinical Gynecology And Obstetrics, 2015; 4(2):197-202
14. Sharma RK, Parashar A. The management of perineal wounds. Indian J Plast Surg. 2012; 45(2):352-363
15. Chang, CC., Lan, YT., Jiang, JK. et al. Risk factors for delayed perineal wound healing and its impact on prolonged hospital stay after abdominoperineal resection. World J Surg, 2019; Onc 17:226
16. Okeahialam NA, Thakar R, Kleprlikova H, Taithongchai A, Sultan AH. Early re-suturing of dehisced obstetric perineal wounds: A 13-year experience. Eur J Obstet Gynecol Reprod Biol, 2020; 254:69-73
17. Carter-Brooks CM, Du AL, Ruppert KM, Romanova AL, Zyczynski HM. Implementation of a urogynecology-specific enhanced recovery after surgery (ERAS) pathway. Am J Obstet Gynecol, 2018; 219(5):495.e1-495.e10
18. Abramov Y, Golden B, Sullivan M, Goldberg RP, Sand PK. Vaginal incisional wound healing in a rabbit menopause model: a histologic analysis. Int Urogynecol J. 2012; 23(12):1763-9
19. Gurtner GC, Chapman MA. Regenerative Medicine: Charting a New Course in Wound Healing. Adv Wound Care (New Rochelle), 2016; 5(7):314-328.
20. Nilforoushzadeh MA, Sisakht MM, Seifalian AM, Amirkhani MA, Banafshe HR, Verdi J, Sharifzad F, Taghiabadi E. Regenerative Medicine Applications in Wound Care. Curr Stem Cell Res Ther, 2017; 12(8):658-674
21. Medvedev VL, Opolskiy AM, Gorban NA, Kogan MI. [Morphological analysis of the structure of parafistulous tissues in patients with vesicovaginal fistulas by the local interstitial application of platelet-rich plasma]. Urologiia, 2021 Mar; 1:21-26
22. Kim HJ, Pyun JH, Park TY, Yoon SG, Maeng SW, Choi HS, Joo KI, Kang SH, Cha HJ. Preclinical evaluation of a regenerative immiscible bioglue for vesico-vaginal fistula. Acta Biomater. 2021; 15(125):183-196
23. Jepsen MS, Sellathurai J, Conti A, Schrøder HD, Lund L. Treatment of Vesicovaginal Fistulas With Autologous Cell Injections-A Randomized Study in an Animal Model. Technol Cancer Res Treat. 2017; 16(6):793-800
24. Stamatakos M, Sargedi C, Stasinou T, Kontzoglou K. Vesicovaginal fistula: diagnosis and management. Indian J Surg. 2014; 76(2):131-136
203 Views | 17 Downloads
How to Cite
Kurniawati EM, Rahmawati NA. The Role of Regenerative Medicine in Wound Healing in Cases of Vesicovaginal Fistulae. JDDT [Internet]. 15Aug.2021 [cited 10Aug.2022];11(4-S):5-. Available from: