Regenerative Medicine in Urogynecological Services: Opportunities in Cases of Stress Urinary Incontinence

  • Eighty Mardiyan Kurniawati Lecturer, Urogynecology Reconstructive Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, Indonesia https://orcid.org/0000-0002-7682-9275
  • Nur Anisah Rahmawati Research Assistant, School of Midwifery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia https://orcid.org/0000-0002-6914-4315

Abstract

Stress urinary incontinence (SUI) is a case that often occurs in women. The handling of this case is not yet fully effective, even though the challenge of health care is to provide quality services and adjust to the needs of the patient. The purpose of this study was to examine the effectiveness of regenerative medicine applied in urogynecology especially in stress urinary incontinence cases as a preliminary study. A selective database search of PubMed, and Google Scholar was conducted to validate the effectiveness of regenerative medicine in urogynecology especially urinary stress incontinence. The search included experimental research, written in English, and has Leak Point Pressure assessment data in the results analysis. Research involves both animals and humans. The search used the following keywords in various combinations: 'stem cell therapy', 'cell-based therapy for SUI', 'regenerative medicine for SUI', and 'tissue engineering'. LPP is an assessor of the success of SUI's services. Most of the studies explored the success and potential of stem cell utilization in cases of stress urinary incontinence even with different types of stem cells. Future studies need to test or experiment the manufacture of stem cell products that can be applied more easily and in the long term.


Keywords: Stress urinary incontinence, stem cell, regenerative medicine

Keywords: Stress urinary incontinence, stem cell, regenerative medicine

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Author Biographies

Eighty Mardiyan Kurniawati, Lecturer, Urogynecology Reconstructive Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, Indonesia

Lecturer, Urogynecology Reconstructive Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, Indonesia 

Nur Anisah Rahmawati, Research Assistant, School of Midwifery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Research Assistant, School of Midwifery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

References

1. Gianluca Sampogna, Salman Yousuf Guraya, Antonello Forgione, Regenerative medicine: Historical roots and potential strategies in modern medicine. Journal of Microscopy and Ultrastructure. Volume 3, Issue 3, September 2015, Pages 101-107
2. Prafulla Chandra James J. YooSang Jin Lee. Chapter 13 - Biomaterials in Regenerative Medicine: Challenges in Technology Transfer from Science to Process Development. Translational Regenerative Medicine 2015, Pages 151-167
3. Lone FW, Raveendran A. Urogynecology Service at a District General Hospital in the United Kingdom - Changing Needs or a Better Understanding?. J Midlife Health. 2019; 10(3):131-134. DOI: http://dx.doi.org/10.4103/jmh.JMH_50_18
4. Lowenstein L, Rosenblatt PL, Dietz HP, Bitzer J, Kenton K. New advances in urogynecology. Obstet Gynecol Int. 2012; 2012:453059. DOI: http://dx.doi.org/10.1155/2012/453059
5. Magon N, Kalra B, Malik S, Chauhan M. Stress urinary incontinence: What, when, why, and then what?. J Midlife Health. 2011; 2(2):57-64. DOI: http://dx.doi.org/10.4103/0976-7800.92525
6. Reynolds WS, Dmochowski RR, Penson DF. Epidemiology of stress urinary incontinence in women. Curr Urol Rep. 2011 Oct; 12(5):370-6. doi: http://dx.doi.org/10.1007/s11934-011-0206-0 . PMID: 21720817.
7. Jiang M, Liu J, Liu W, et al. 2021 Bone marrow stem cells secretome accelerates simulated birth trauma-induced stress urinary incontinence recovery in rats. Aging (Albany NY). 2021; 13(7):10517-10534.
DOI: http://dx.doi.org/10.18632/aging.202812
8. Jalali Tehrani H, Daryabari SS,Fendereski K, Alijani Zirdehi M, Kajbafzadeh A-M. Applicationof adipose-derived, muscle-derived, and co-cultured stem cellsfor the treatment of stress urinary incontinence in rat models. Lower Urinary Tract Symptoms. 2020; 1–11.DOI https://doi.org/10.1111/luts.12360
9. Wang Y, Duan M, Rahman M, Yang M, Zhao W, Zhou S, Gao G, Fu Q. Use of bioactive extracellular matrix fragments as a urethral bulking agent to treat stress urinary incontinence. Acta Biomater. 2020 Nov; 117:156-166. DOI: http://dx.doi.org/10.1016/j.actbio.2020.09.049 . Epub 2020 Oct 6. PMID: 33035698.
10. Zhuang G, Wen Y, Briggs M, et al. Secretomes of human pluripotent stem cell-derived smooth muscle cell progenitors upregulate extracellular matrix metabolism in the lower urinary tract and vagina. Stem Cell Res Ther. 2021; 12(1):228. Published 2021 Apr 6. DOI: http://dx.doi.org/10.1186/s13287-021-02292-y
11. Bertha Cen. The role of regenerative medicine in obstetrics and gynecology. 5th International Conference on Tissue Engineering & Regenerative Medicine. September 12-14, 2016 Berlin, Germany
12. Weber AM. Leak point pressure measurement and stress urinary incontinence. Curr Womens Health Rep. 2001 Aug; 1(1):45-52. PMID: 12112951
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Kurniawati EM, Rahmawati NA. Regenerative Medicine in Urogynecological Services: Opportunities in Cases of Stress Urinary Incontinence. JDDT [Internet]. 20May2021 [cited 18Sep.2021];11(3):86-8. Available from: https://jddtonline.info/index.php/jddt/article/view/4807