Does BMI Really Alter the Hormonal Profile in Infertile Women? Retrospective Study in the Region of Sidi Bel Abbes (West Algeria)
THE HORMONAL PROFIL IN INFERTILE WOMEN? RETROSPECTIVE STUDY IN THE REGION OF SIDI BEL ABBES (WEST ALGERIA)
Abstract
Background: In last few years .; it’s increasingly being recognized that Reproductive function is controlled by the hypothalamic–pituitary– gonadal axis, which is regulated by numerous endogenous and environmental factors such us adipose accumulation in obesity contributing to reproductive failure such as menstrual disorders and infertility, gestational failure and obstetric complications, and infertility , Distinct changes in circulating sex hormones appear to underline these abnormalities.The objective: The aim of this study was to elucidate the possible correlation between body mass index as fatness indicator and hormonal profile in infertile women from the west of Algeria.
To identify the impact of overweight and obesity on female hormonal profile ; we conducted a prospective study measuring pituitary hormones (FSH and LH and prolactin ) , steroid sex hormones ( progesterone , testosterone and estradiol ) , anti miulleian hormone , and thyroidal hormones (FT3 , FT4 and TSH) in 360 women consulting for subfertility in private genecologycal and obstetrical centers in SID BELABESS (West of Algeria )
Result: Our study showed that the majority of patients were aged between 20 and 29 years, representing a percentage of 47.8%, with the average age in sample (31.65 ± 6,93ans). The majority of subjects was obese 46.4%, or overweight (39.4%) with an average BMI of (29.76 ± 4,85Kg / m2). No statistically significant association was found between the BMI as obesity indicator with hormonal levels of pituitary hormones (FSH and LH and prolactin ) , steroid sex hormones ( progesterone , testosterone and estradiol ) , anti miulleian hormone , and thyroidal hormones (FT3 , FT4 and TSH). A negative and statistically significant correlation between the age of the patients and the AMH level (R = -0.60, P <0.01) was noted.
Conclusion: The results of our study showed that the majority of women included in our study had a high BMI but no statistical significant difference was found between underweight , normal , overweight and obese women , that’s why more studies should be conducted to elucidate the in which level does obesity impair the reproductive outcomes.
Keywords: Female infertility, hormonal profile, BMI, SBA, Algeria.
Keywords:
BMI, SBA, Algeria, Female infertility, hormonal profile
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References
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2. Nuttall, F. Q. Body mass index: obesity, BMI, and health: a critical review. Nutrition today. 2015; 3:117.
3. Pandey, S., Maheshwari, A., & Bhattacharya, S. The impact of female obesity on the outcome of fertility treatment. Journal of human reproductive sciences. 2010; 2:62.
4. Campos, D. B., Palin, M. F., Bordignon, V., & Murphy, B. D. The'beneficial'adipokines in reproduction and fertility. International Journal of Obesity. 2008; 2:223.
5. Norman, J. E. The adverse effects of obesity on reproduction. Reproduction. 2010; 140:343-5.
6. Norman JE, The adverse effects of obesity on reproduction, Reproduction, 2010; 140(3):343-345. doi: 10.1530/REP-10-0297
7. Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B. Oxidative stress and antioxidants: exposure and impact on female fertility. Human reproduction update . 2008; 14:345-357.
8. Isa AM, Abu-Rafea B, Alasiri SA, Binsaleh S, Ismail KH, Vilos GA. Age, body mass index, and number of previous trials: are they prognosticators of intra-uterine-insemination for infertility treatment?. International Journal of Fertility & Sterility. 2014; 8(3):255-260
9. FERIEL BOUDIA, ABBASSIA DEMMOUCHE AND HICHAM ABDESSALEM MAÏ. THE IMPACT OF FEMALE BODY WEIGHT ON INFERTILITY. Journal of Disease and Global Health. . 2015; 3:34-38
10. Filer, B. R. Obesity and reproduction. JLGH. . 2009; 4(4):134-135.
11. Roth, L. W., Allshouse, A. A., Bradshaw‐Pierce, E. L., Lesh, J., Chosich, J., Kohrt, W., ... & Santoro, N. Luteal phase dynamics of follicle‐stimulating and luteinizing hormones in obese and normal weight women. Clinical endocrinology. 2014; 81(3):418-425.
12. Pasquali, R., Pelusi, C., Genghini, S., Cacciari, M., & Gambineri, A. Obesity and reproductive disorders in women. Human reproduction update. 2003; 9(4):359-372.
13. Crujeiras, A. B., & Casanueva, F. F. Obesity and the reproductive system disorders: epigenetics as a potential bridge. Human reproduction update. . 2014; 21(2):249-261.
14. MAÏ HA, Demmouche A. A Case- Control study of Body Mass Index and Infertility in Algerian Women (Sidi Bel Abbes, West of Algeria). Int J Infertil Fetal Med . 2015; 6(3):103-107.
15. Caillon, H., Fréour, T., Bach-Ngohou, K., Colombel, A., Denis, M. G., Barrière, P., & Masson, D. Effects of female increased body mass index on in vitro fertilization cycles outcome. Obesity research & clinical practice. . 2015; 9(4):382-388.
16. Jain, A., Polotsky, A. J., Rochester, D., Berga, S. L., Loucks, T., Zeitlian, G., & Santoro, N. Pulsatile luteinizing hormone amplitude and progesterone metabolite excretion are reduced in obese women. The Journal of Clinical Endocrinology & Metabolism. 2007; 92(7):2468-2473.
17. Navarro, G., Allard, C., Xu, W., & Mauvais‐Jarvis, F. The role of androgens in metabolism, obesity, and diabetes in males and females. Obesity. 2015; 23(4):713-719.
18. Hormones, E., & Breast Cancer Collaborative Group. Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies. The lancet oncology. 2013; 14(10):1009-1019.
19. Schummers L, Hutcheon JA, Bodnar LM, et al. Risk of adverse pregnancy outcomes by prepregnancy body mass index: a populationbased study to inform prepregnancy weight loss counseling. Obstet Gynecol 2015 ; 125:133–43.
20. Marchi J, Berg M, Dencker A, et al. Risks associated with obesity in pregnancy, for the mother and baby: a systematic review of reviews. Obes Rev 2015 ; 16:621–38.
21. Sanabria-Martínez G, García-Hermoso A, Poyatos-León R, et al. Effectiveness of physical activity interventions on preventing gestational diabetes mellitus and excessive maternal weight gain: a meta-analysis. BJOG 2015 ; 122:1167–74.
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KHALLOUA ZC, CHEBLI I, MEZIANI S, FERRAG D, ITATAHINE A, MAI H, BEKHADDA H, BENALI AI, Bensaid I, Demmouche A, Belbraouet S. Does BMI Really Alter the Hormonal Profile in Infertile Women? Retrospective Study in the Region of Sidi Bel Abbes (West Algeria). JDDT [Internet]. 15Aug.2020 [cited 20May2024];10(4-s):142-7. Available from: https://jddtonline.info/index.php/jddt/article/view/4320
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