Relation between Concentrations of Lead, Cadmium and Mercury in Cord Blood and Prematurity in the Sidi Bel Abbes Region (West of Algeria)

Authors

  • Hadjer Bouhadiba Biotoxicology Laboratory, Department of Biology. Faculty of Naturel Science and life. Djillali Liabes University; Sidi Bel Abbes. Algeria
  • Abbassia Demmouche Biotoxicology laboratory. Department of biology. Faculty of Naturel Science and life. Djillali Liabes University; Sidi Bel Abbes. Algeria.

Abstract

Background: Exposure to heavy metals such as lead, cadmium and mercury during pregnancy carries a great risk to the mother as well as the fetus. Methods: Lead, cadmium and mercury were measured in umbilical cord blood samples of 3 groups women (30 women’s for lead, 30 cadmium and 10 from mercury) in maternity of Sidi Bel Abbes region in Algeria between 2016 and 2017.The objective of this study was to measure in the blood of the umbilical cord the concentration of lead (Pb), mercury (Hg) and cadmium (Cd), and to evaluate the relationship between these levels and prematurity. The lead, cadmium and mercury levels were measured by atomic absorption. Results: The study showed obvious variations in, maternal characteristics. The results revealed several factors predisposing to prematurity. The mean concentrations of cord blood lead, cadmium and mercury were; 18.97 µg/L, 0.26 µg/L, and6.20 nmol/L, respectively.  There was a highly significant direct correlation between cord lead concentrations and gestational age(r=0.43; P = 0.017), and we found that gestational age and birth weight inversely correlated with cord mercury concentration (r=0.44 and r=0.57 respectively).No correlation was observed between cord cadmium concentrations and gestational age. Conclusion: This study has shown that pregnant women in this region were exposed to high levels for heavy metalswhich need an intervention.

Keywords: Lead. Cadmium, Mercury, Pregnancy, Prematurity, Fetal exposure, Algeria.

Keywords:

Lead, Mercury, Pregnancy, Prematurity, Fetal exposure, Algeria

DOI

https://doi.org/10.22270/jddt.v10i2-s.4020

Author Biographies

Hadjer Bouhadiba, Biotoxicology Laboratory, Department of Biology. Faculty of Naturel Science and life. Djillali Liabes University; Sidi Bel Abbes. Algeria

Biotoxicology Laboratory, Department of Biology. Faculty of Naturel Science and life.  Djillali Liabes University; Sidi Bel Abbes. Algeria

Abbassia Demmouche, Biotoxicology laboratory. Department of biology. Faculty of Naturel Science and life. Djillali Liabes University; Sidi Bel Abbes. Algeria.

Biotoxicology Laboratory, Department of Biology. Faculty of Naturel Science and life.  Djillali Liabes University; Sidi Bel Abbes. Algeria

References

Health Canada, Arsenic —Guidelines for Canadian Drinking Water Quality: Guideline Technical Document. Available from: 〈http://www.hc-sc.gc.ca/ewh- semt/pubs/water-eau/arsenic/index-eng.php〉 ;( 2006): (cited 01.08.13)

Sanders T, Liu Y, Buchner V, Tchounwou PB. Neurotoxic effects and biomarkers of lead exposure: a review. Rev Environ Health 2009; 24:15–45

Myatt, Placental adaptive responses and fetal programming. J.Physiol. 2006; 572:25–30

Thomas R. Frieden, MD, MPH Lead Poisoning in Pregnant Women Who Used Ayurvedic Medications from India. Centers for Disease Control and Prevention.2012; 61:33.

Vigeh M, Yokoyama K, Kitamura F, AfshinrokhM, Beygi A, Niroomanesh. Early pregnancy blood lead and spontaneous abortion. Women Health.2010; 50:756-66

Bellinger DC. Teratogen update: lead and pregnancy. Birth Defects Res A ClinMol Teratol.2005; 73:409-20

Chen PC, Pan IJ, Wang JD. Parental exposure to lead and small for gestational age births. Am J Ind Med. 2006; 49:417-22

Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy Metals Toxicity and the Environment. EXS. 2012; 101:133-164

Raymond A. Wuana and Felix E. Okieimen. “Heavy Metals in Contaminated Soils: A Review of Sources, chemistry, Risks and Best Available Strategies for Remediation,” ISRN Ecology. 2012; 20

Erbi P. Ikeh-Tawari. John.Anetor. M. A. Charles- Davies. Cadmium Level in Pregnancy, Influence on Neonatal Birth Weight and Possible Amelioration by Some Essential Trace Elements. Toxico.Int.2013; 20(1):108–112

Thomas Nissen. An In-depth Report on the Effects of Mercury Poisoning Toxicity, Evenbetterhealth.com.2010.

Bernard, A.M. Biokinetics and stability aspects of biomarkers: recommendations for application in population studies. Toxicology.1995; 101:65–71

Röllin HB, Rudge CV, Thomassen Y, Mathee A, Odland JØ. Levels of toxic and essential metals in maternal and umbilical cord blood from selected areas of South Africa--results of a pilot study. J Environ Monit.2009; 11:618-27

Butler Walker J, Houseman J, Seddon L, McMullen E, Tofflemire K, Mills C.et al. Maternal and umbilical cord blood levels of mercury, lead, cadmium, and essential trace elements in Arctic Canada. Environ Res.2006; 100:295–318

Amaral, J.H., Rezende, V.B., Quintana, S.M., Gerlach, R.F., Barbosa, F.Jr., Tanus-Santos,J.E.The relationship between blood and serum lead levels in peri-partum women and their respective umbilical cords. basicClin. Pharmacol. Toxicol. 2010.

Koppen, G., Den Hond, E., Nelen, V., Van De Mieroop, E., Bruckers, L., Bilau, M., Keune,H., Van Larebeke, N., covaci, A., Van De Weghe, H., Schroijen, C., Desager, K., Stalpaert, M., Baeyens, W., Schoeters, G. organ chlorine and heavy metals in new-born’s: Results from the Flemish Environment and health Survey (FLEHS2002-2006). Environ. Int.2009; 35:1015–1022

Kirel, B., Akit, M.A., Bulut, and H. Blood lead levels of maternal-cord pairs, children and adults who live in a central urban area in Turkey. Turk. J. Pediatr.2005; 47:125–131

Bismuth C., Baud F., Conso F. Toxicologie clinique. Flammarion Médecine-Sciences, 5ème édition, Paris.2012; 1092.

Chen LH, Petitti DB Case-control study of passive smoking and the risk of small-for-gestational-age at term. Am J Epidemiol. 1995; 142(2):158-165.

Shari Thomas, TyeE. Arbuckle, Mandy Fisher, William D. Fraser, Adrienne Ettinger, Will King. Metals exposure and risk of small-for-gestational age birth in a Canadian birth cohort: The MIREC study. Environmental research.2015; 140:430-439.

Perkins M, Wright RO, Amarasiriwardena CJ, et al. Very low maternal lead level in pregnancy and birth outcomes in an eastern Massachusetts population. Ann Epidemiol.2014; 24:915-9

Satarug, S., Moore, M.R. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ. Health Perspect.2004; 112:1099-1103

Al-Saleh, I., Shinwari, N., Mashhour, A., Rabah, A. Birth outcome measures and maternal exposure to heavy metals (lead, cadmium and mercury) in Saudi Arabian population. Int. J. Hyg. Environ. Health. 2013.

Zhang, Y.L., Zhao, Y.C., Wang, J.X., Zhu, H.D., Liu, Q.F., Fan, Y.G., Wang, N.F., Zhao, J.H., Liu, H.S., Ou-Yang, L., Liu, A.P., Fan, T.Q. Effect of environmental exposure to cadmium on pregnancy outcome and fetal growth: a study on healthy pregnant women in China. J. Environ. Sci. Health A Tox. Hazard subst. Environ. Eng.2004; 39:2507-2515

Parajuli, R.P., Fujiwara, T., Umezaki, M., Furusawa, H., Ser, P.H., Watanabe, C. Cord blood levels of toxic and essential trace elements and their determinants in the Terai region of Nepal: a birth cohort study. Biol. traces Elem. Res.2012; 147:75-83

OSHA (Occupational Safety and Health Administration). Occupational Exposure to Cadmium: Final Rules. US Department of Labor, Federal Register.1992; 57:42101-42463

Jarup, L., Akesson, A. Current status of cadmium as an environmental health problem. Toxicol. Appl. Pharmacol.2009; 238:201-208

Guan, H., Piao, F.Y., Li, X.W., Li, Q.J., Xu, L., Yokoyama, K. Maternal and foetal exposure to four carcinogenic environmental metals. Biomed. Environ. Sci.2010; 23:458-465

Thompson J, Bannigan J. Cadmium: toxic effects on the reproductive system and the embryo. Reprod Toxicol.2008; 25(3):304-15

Yang Q, Wen SW, Smith GN, Chen Y, Krewski D, Chen XK, et al. Maternal cigarette smoking and the risk of pregnancy-induced hypertension and eclampsia. International journal of epidemiolog.2006; 35:288-93

Loiacono,N.J., Graziano,J.H., Kline,J.K., Popovac,D., Ahmedi,X., Gashi,E., etal. Placental cadmium and birth weight in women living near aleadsmelter. Arch. Environ. Health.1992; 47:250–255

Kippler, M., Tofail, F., Gardner, R., Rahman, A., Hamadani, J.D., Bottai, M., et al. Maternal cadmium exposure during pregnancy and size at birth: prospective cohort study. Environ. Health Perspect. 2011; 120:284–289

Nishijo,M., Tawara,K. ,Honda,R. ,Nakagawa, H., Tanebe, K., Saito, S. Relationship between new born size and mother’s blood cadmium levels Toyama, Japan. Arch.Environ.Health.2004; 59:22-25

Tian, L.-L., Zhao, Y.-C., Wang, X.-C., Gu, J.-L.,Sun, Z.-J., Zhang, Y.-L., et al. Ef- facts of gestational cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. Biol. Trace Elem.Res.2009; 132:51–59

Murphy VE, Smith R, Giles WB, Clifton VL. Endocrine regulation of human foetal growth: the role of the mother, placenta, and fetus. Endocr Rev.2006; 27:141-69

US EPA, Environmental Protection Agency. Mercury. Human exposure Available:

(accessed 13.03.2007) http://www.epa.gov/mercury/exposure.htm.

Al-Saleh I, , Shinwaria N, Mashhoura A, Gamal El Din M, Rabah A. Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women. International Journal of Hygiene and environmental Health.2011; 214:79-101

Word health organization. Elementary mercury and inorganic mercury compounds. Human health aspects. Concise international chemical Assessment. Document 50. Geneva, 2003.

Urbach,J., Boadi, W., Brandes, J.M., Kerner,H., Yannai, S. Effect of inorganic mercury on in vitro placental nutrient transfer and oxygen consumption. Re- prod. Toxicol.ElmsfordNY.1992; 6:69-75

Jedrychowski,W., Jankowski, J., Flak, E.,S karupa,A., Mroz,E., Sochacka-Tatara, E., et al. Effects of prenatal exposure to mercury on cognitive and psycho- motor function in one-year-old infants: epidemiologic cohort study in Poland. Ann. Epidemiol. 2006; 16:439-447

Foldspang, A., Hansen, J.C. Dietary intake off methyl mercury as a correlate of gestational length and birth weight among new borns in Greenland. Am.J. Epidemiol.1990; 132:310-317

Lee, B.-E., Hong, Y.-C., Park, H., Ha, M., Koo, B.S., Chang, N., et al. Interaction between GSTM1/GSTT1 Polymorphism and Blood Mercury on Birth Weight. Environ Health Perspect.2010; 118:437-44

Published

15-04-2020
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How to Cite

1.
Bouhadiba H, Demmouche A. Relation between Concentrations of Lead, Cadmium and Mercury in Cord Blood and Prematurity in the Sidi Bel Abbes Region (West of Algeria). J. Drug Delivery Ther. [Internet]. 2020 Apr. 15 [cited 2025 Feb. 14];10(2-s):58-63. Available from: https://jddtonline.info/index.php/jddt/article/view/4020

How to Cite

1.
Bouhadiba H, Demmouche A. Relation between Concentrations of Lead, Cadmium and Mercury in Cord Blood and Prematurity in the Sidi Bel Abbes Region (West of Algeria). J. Drug Delivery Ther. [Internet]. 2020 Apr. 15 [cited 2025 Feb. 14];10(2-s):58-63. Available from: https://jddtonline.info/index.php/jddt/article/view/4020

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