Antidyslipidaemic and cardioprotective effects of turmeric (Curcuma longa) in rat fed a high cholesterol diet
Abstract
Objective: The aim of this study is to evaluate the antidyslipidaemic and cardioprotective effects of aqueous extract of Curcuma longa (AECL) in rats fed a high cholesterol diet (HCD).
Methods: Twenty (20) rats were randomly grouped into four groups: A-D of five animals per group. Groups A-C received HCD (2000mg/kg, oral) and carbimazole (60mg/kg, oral) daily for eight weeks. Group A served as negative control. Group B (positive control) was treated with atorvastatin (20mg/kg), while group C served as treatment group and received AECL (400mg/kg) daily for eight weeks. Group D served as normal control and received no treatment. After the administration, biochemical markers of Lipid profiles (total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-C)) were assayed using standard methods. The hearts of the rats were harvested for histopathological studies.
Results: AECL significantly induced hypolipidaemia and stabilized lipid biochemical markers (p<0.05 or p<0.01); and protected the cardiac muscle fibres from injuries.
Conclusion: Tumeric (Curcuma longa) has antidyslipidaemic and cardioprotective effects.
Keywords: antidyslipidaemia, cardioprotection, Curcuma longa, ethnopharmacology, hypercholesterolaemia, Medicinal foods, cardiomyopathy
Keywords:
antidyslipidaemia, cardiomyopathy, cardioprotection, Curcuma longa, ethnopharmacology, hypercholesterolaemiaDOI
https://doi.org/10.22270/jddt.v10i1-s.3869References
Uchendu IK, Onwukwe SO, Agu CE, Orji CO, Eluke BC, Nwosu TF. Hypolipidaemic and renoprotective effects of Glycine max (soy bean) against lipid profile and renal biochemical alterations in hypercholesterolemic rat. International Journal of Biomedical Research. 2016; 7:822-828.
Al-Taee MF, Al-Ahmed HI, Abdul Malek HW. Studying the Effect of Aqueous Extract from Curcuma Longa on Some Parameters of Cytogenetic, Immunity and Fertility in Female Mice. Baghdad Science Journal. 2011; 8:73-879.
Trease G, Evans SM. Pharmacognosy: (15th Edition). English Language Book Society. Bailliere Tindall, London, 2002; pp 23-67.
Mizoguchi T, Edano T, Koshi T. A method of direct measurement for the enzymatic determination of cholesteryl esters. J Lipid Res. 2004; 45:396-401
Hafiane A, Genest J. High density lipoproteins: Measurement techniques and potential biomarkers of cardiovascular risk. Biochimical et Biophysica Acta- Clinical. 2015; 3:175-188.
Al-Anzi B, Zinn K. Colorimetric Measurement of Triglycerides Cannot Provide an Accurate Measure of Stored Fat Content in Drosophila. PLoS One, 2010; 5(8):e12353.
Baker FJ, Silverton RE, Pallister CJ Baker and Silverton’s Introduction to Laboratory Technology. 7th Edition, Butterworth-Heinemann, Wobrun, MA, USA, 1998; page 448.
Gurcan MN, Boucheron L, Can A, Madabhushi A, Rajpoot N, Yener B. Histopathological image analysis: A review. IEEE Reviews in Biomedical Engineering. 2009; 2:147-171.
Chandurkar V, Shik, J, Randell E. Hyperthyroidism caused by proteinuria and induction of urinary thyroixine loss: case report and subsequent investigation. Journal of Endocrine Practice, 2008; 14:97−103.
Orji OC, Uchendu IK, Agu CE, Nnedu EB, Okerreke AN, Orji GC. Combined Effects of Vitamin C and Tomato Extract (Lycopersicon Esculentum) on Carbimazole-induced Alterations in the Testes of Male Albino Rats. Indian Journal of Physiology and Pharmacology. 2018; 62:380−384.
Saber AS, Sobhy EE, Yosry, AO. Ahmed. Impact of ginger aqueous extract on carbimazole induced testiculardegenerative alterations and oxidative stress in albino rats. Journal of Costal Life Medicine. 2017; 5:167−173.
Silaste ML, Ranatala M, Alfthan G, Aro A. Kesaniemi YA. Plasma homocysteine concentration is decreased by dietary intervention. British Journal of Nutrition. 2003; 89:295-301.
Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. Journal of Nutritional Science. 2016; 5:1-15.
Cherrak SA, Mokhtari-Soulimane N, Berroukeche F, Bensenane B, Cherbonnel A, Merzouk H, Elhabiri M. In vitro antioxidant versus metal ion chelating properties of flavonoids: A structure-activity investigation. Plos One, 2016; 11(10):e0165575.
Mahmoud AM, Bautista RJH, Sandhu MA, Hussein OE. Beneficial effects of citrus flavonoids on cardiovascular and metabolic health. Oxidative Medicine and Cellular Longevity. 2019; 2019:ID 5484138, 19 pages.
Kooti W, Hasanzadeh-Nooti Z, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D. Phytochemistry, Pharmacology and therapeutic uses of black seed (Nigella Savita). Chinese Journal of Natural Medicines. 2016; 14(10):732-745.
Published
Abstract Display: 724 
PDF Downloads: 820 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.