Particle Engineering Techniques: A Boon in Enhancing Dissolution Rate of Poorly Water Soluble Drugs
Abstract
For any dosage forms enhancing dissolution is the first criteria i.e. it should give increased bioavailability in order to provide onset of action. In market many poorly soluble drugs are available which are having problem of low solubility. Low solubility of these poorly water soluble drugs are the main issue factor in preparing dosage forms of these drugs as with low solubility enhanced or effective dissolution to reach therapeutic effect is difficult. To overcome these problems there are main engineering techniques came in market which helps in enhancing the dissolution of these drugs. Some of the common use techniques are cryogenic, super critical fluid technology, evaporative precipitation into aqueous solution, nano- milling methods were developed based on the drug properties and required nanoparticles character. Making use of these techniques has increases the in vitro dissolution rates and in vivo bioavailability of many poorly water soluble drugs. This review highlights about the materialistic availability of particle engineering processes recently reported in the literature for enhancing the dissolution properties of poorly water soluble drugs.
Keywords: Solubility. Dissolution Rate, Poorly Soluble Drugs, Particle Engineering Techniques
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