Superdisintegrant: crucial elements for mouth dissolving tablets

  • Rada Santosh Kumar GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India
  • Annu Kumari GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India
DOI https://doi.org/10.22270/jddt.v9i2.2480

Abstract

Mouth dissolving tablets have gained more popularity among solid oral dosage forms. They perform better than conventional tablets because of its ease of administration and patient’s compliance. It facilitates water less administration and rapid onset of action. It also helps in improving oral bioavailability. The fast disintegration followed by dissolution leads to quick therapeutic activity makes these tablets superior over available tablets and capsules. Disintegration is an important key step for any solid dosage forms to show its pharmacologic effect as any solid dosage forms should disperse into its fine particles from which it is prepared. In mouth dissolving tablets superdisintegrants are incorporated in right amount for quick disintegration with improved bioavailability. Based on the source various types of superdisintegrants are available. They are synthetic, semi-synthetic, natural, and co-processed.  In this review, main emphasis is given on different types of superdisintegrants used in mouth dissolving tablets, their mechanisms and applications.


Keywords: Superdisintegrants, Mouth dissolving, Disintegration, Bioavailability

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Author Biographies

Rada Santosh Kumar, GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India

GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India

Annu Kumari, GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India

GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India

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1.
Santosh Kumar R, Kumari A. Superdisintegrant: crucial elements for mouth dissolving tablets. JDDT [Internet]. 15Mar.2019 [cited 18Apr.2024];9(2):461-8. Available from: https://jddtonline.info/index.php/jddt/article/view/2480
Issue
Vol 9 No 2 (2019): Volume 9, Issue 2 March-April 2019
Section
Review
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