Formulation and Evaluation of Mefenamic Acid Solid Dispersions Employing Starch Citrate-A New Solubility Enhancer
Abstract
Solid dispersions refer to the group of solid products consisting of at least a hydrophilic carrier and hydrophobic drug. Drug is molecularly dispersed in amorphous form. Solubility and dissolution rate is the rate determining step for bioavailability of mefenamic acid, a BCS class II drug. In this paper, preparation of starch citrate and evaluation of it, as a solubility enhancer by formulating solid dispersion using mefenamic acid will be discussed. For evaluation, as solubility enhancer, of starch citrate in vitro evaluation of solid dispersion (prepared by physical method, solvent evaporation method and kneading method) was done. Starch citrate found to be a novel carrier and solubility enhancer of poorly soluble drugs.
Keywords: Mefenamic acid, Starch citrate, Solid dispersion & In vitro studies, physical method, solvent evaporation, kneading method
DOI
https://doi.org/10.22270/jddt.v9i2-s.2585References
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